P450

Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and breakdown. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones.CYPs are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. The term "P450" is derived from the spectrophotometric peak at the wavelength of the absorption maximum of the enzyme (450 nm) when it is in the reduced state and complexed with carbon monoxide. Most CYPs require a protein partner to deliver one or more electrons to reduce the iron (and eventually molecular oxygen).

Cat. No.	Product name	CAS No.	Purity
T6030	XL388	1251156-08-7	99.53%
T6030	XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.
T7056	Dronedarone	141626-36-0	99.55%
T7056	Dronedarone is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.
T3610	Ranitidine	66357-35-5	99.56%
T3610	Ranitidine is a non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.
T1443	Memantine hydrochloride	41100-52-1	99.56%
T1443	Memantine hydrochloride is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparkinson agent.
T22391	Omeprazole Sodium	95510-70-6	99.57%
T22391	Omeprazole Sodium, the sodium salt form of omeprazole, is a proton pump inhibitor and suppresses gastric acid secretion.
T6509	Galeterone	851983-85-2	99.57%
T6509	Galeterone is an orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase inhibitor with potential antiandrogen activity. Galeterone exhibi...
T3698	Alpha-Asarone	2883-98-9	99.59%
T3698	Alpha-Asarone is a psychoactive compound with antidepressant-like activity in mice.
T3401	Ginsenoside F1	53963-43-2	99.6%
T3401	Ginsenoside F1 is an enzymatically modified derivative of ginsenoside Rg1, showing competitive inhibition of the activity of CYP3A4 and a weaker inhibition of th...
T21425	Mephenytoin	50-12-4	99.61%
T21425	Mephenytoin (racemic) is a hydantoin, used as an anticonvulsant.
T0679	Ketoconazole	65277-42-1	99.62%
T0679	Ketoconazole, a CYP3A4 inhibitor, is an imidazole anti-fungal agent.
T6246	Cobicistat	1004316-88-4	99.62%
T6246	Cobicistat is a carbamate and thiazole derivative that functions as a CYTOCHROME P450 CYP3A INHIBITOR to enhance the concentration of ANTI-HIV AGENTS, with which...
TQ0296L	N-Nornuciferine hydrochloride(4846-19-9 free base)	TQ0296L	99.63%
TQ0296L	N-Nornuciferine is an aporphine alkaloid in lotus leaf, significantly inhibits CYP2D6 (IC50: 3.76 μM, Ki: 2.34 μM).
T6S0630	Hypaconitine	6900-87-4	99.63%
T6S0630	Hypaconitine, an active and highly toxic constituent derived from Aconitum species, has anti-inflammatory activity, is widely used to treat rheumatism.
T2770	Gentiopicroside	20831-76-9	99.64%
T2770	Gentiopicroside, a naturally occurring iridoid glycoside, extracted from Gentiana manshurica Kitag, inhibits P450 activity, with an IC50 and a Ki of 61 μM and 22...
T3811	Ginsenoside C-K	39262-14-1	99.65%
T3811	Ginsenoside C-K is a bacterial metabolite of G-Rb1 exhibiting anti-inflammatory effects by reducing iNOS and COX-2.
T2175	Apigenin	520-36-5	99.66%
T2175	Chamomile is an aromatic oil extracted from the flowers or leaves of the daisy-like plants. Extracts, oils and teas made from chamomile are used for its soothing...
TN1023	Miltirone	27210-57-7	99.66%
TN1023	Miltirone is a CYPs inhibitor, it has been characterized as a low-affinity ligand for central benzodiazepine receptors.
T4567	Sulfaphenazole	526-08-9	99.67%
T4567	Sulfaphenazole is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CYP2C8/CYP2C18...
T0100	Atazanavir sulfate	229975-97-7	99.67%
T0100	Atazanavir sulfate is an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENTS...
T5715	(E)-Flavokawain A	37951-13-6	99.7%
T5715	Flavokavin A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent ap...