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P450

Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and breakdown. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones.CYPs are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. The term "P450" is derived from the spectrophotometric peak at the wavelength of the absorption maximum of the enzyme (450 nm) when it is in the reduced state and complexed with carbon monoxide. Most CYPs require a protein partner to deliver one or more electrons to reduce the iron (and eventually molecular oxygen).
Cat. No. Product name CAS No. Purity Chemical Structure
T6030 XL388 1251156-08-7 99.53%
XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.
T7056 Dronedarone 141626-36-0 99.55%
Dronedarone is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.
T3610 Ranitidine 66357-35-5 99.56%
Ranitidine is a non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.
T1443 Memantine hydrochloride 41100-52-1 99.56%
Memantine hydrochloride is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparkinson agent.
T22391 Omeprazole Sodium 95510-70-6 99.57%
Omeprazole Sodium, the sodium salt form of omeprazole, is a proton pump inhibitor and suppresses gastric acid secretion.
T6509 Galeterone 851983-85-2 99.57%
Galeterone is an orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase inhibitor with potential antiandrogen activity. Galeterone exhibi...
T3698 Alpha-Asarone 2883-98-9 99.59%
Alpha-Asarone is a psychoactive compound with antidepressant-like activity in mice.
T3401 Ginsenoside F1 53963-43-2 99.6%
Ginsenoside F1 is an enzymatically modified derivative of ginsenoside Rg1, showing competitive inhibition of the activity of CYP3A4 and a weaker inhibition of th...
T21425 Mephenytoin 50-12-4 99.61%
Mephenytoin (racemic) is a hydantoin, used as an anticonvulsant.
T0679 Ketoconazole 65277-42-1 99.62%
Ketoconazole, a CYP3A4 inhibitor, is an imidazole anti-fungal agent.
T6246 Cobicistat 1004316-88-4 99.62%
Cobicistat is a carbamate and thiazole derivative that functions as a CYTOCHROME P450 CYP3A INHIBITOR to enhance the concentration of ANTI-HIV AGENTS, with which...
TQ0296L N-Nornuciferine hydrochloride(4846-19-9 free base) TQ0296L 99.63%
N-Nornuciferine is an aporphine alkaloid in lotus leaf, significantly inhibits CYP2D6 (IC50: 3.76 μM, Ki: 2.34 μM).
T6S0630 Hypaconitine 6900-87-4 99.63%
Hypaconitine, an active and highly toxic constituent derived from Aconitum species, has anti-inflammatory activity, is widely used to treat rheumatism.
T2770 Gentiopicroside 20831-76-9 99.64%
Gentiopicroside, a naturally occurring iridoid glycoside, extracted from Gentiana manshurica Kitag, inhibits P450 activity, with an IC50 and a Ki of 61 μM and 22...
T3811 Ginsenoside C-K 39262-14-1 99.65%
Ginsenoside C-K is a bacterial metabolite of G-Rb1 exhibiting anti-inflammatory effects by reducing iNOS and COX-2.
T2175 Apigenin 520-36-5 99.66%
Chamomile is an aromatic oil extracted from the flowers or leaves of the daisy-like plants. Extracts, oils and teas made from chamomile are used for its soothing...
TN1023 Miltirone 27210-57-7 99.66%
Miltirone is a CYPs inhibitor, it has been characterized as a low-affinity ligand for central benzodiazepine receptors.
T4567 Sulfaphenazole 526-08-9 99.67%
Sulfaphenazole is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CYP2C8/CYP2C18...
T0100 Atazanavir sulfate 229975-97-7 99.67%
Atazanavir sulfate is an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENTS...
T5715 (E)-Flavokawain A 37951-13-6 99.7%
Flavokavin A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent ap...
XL388
T6030
XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.
Dronedarone
T7056
Dronedarone is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.
Ranitidine
T3610
Ranitidine is a non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.
Memantine hydrochloride
T1443
Memantine hydrochloride is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparkinson agent.
Omeprazole Sodium
T22391
Omeprazole Sodium, the sodium salt form of omeprazole, is a proton pump inhibitor and suppresses gastric acid secretion.
Galeterone
T6509
Galeterone is an orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase inhibitor with potential antiandrogen activity. Galeterone exhibi...
alpha-Asarone
T3698
Alpha-Asarone is a psychoactive compound with antidepressant-like activity in mice.
Ginsenoside F1
T3401
Ginsenoside F1 is an enzymatically modified derivative of ginsenoside Rg1, showing competitive inhibition of the activity of CYP3A4 and a weaker inhibition of th...
Mephenytoin
T21425
Mephenytoin (racemic) is a hydantoin, used as an anticonvulsant.
Ketoconazole
T0679
Ketoconazole, a CYP3A4 inhibitor, is an imidazole anti-fungal agent.
Cobicistat
T6246
Cobicistat is a carbamate and thiazole derivative that functions as a CYTOCHROME P450 CYP3A INHIBITOR to enhance the concentration of ANTI-HIV AGENTS, with which...
N-Nornuciferine hydrochloride(4846-19-9 free base)
TQ0296L
N-Nornuciferine is an aporphine alkaloid in lotus leaf, significantly inhibits CYP2D6 (IC50: 3.76 μM, Ki: 2.34 μM).
Hypaconitine
T6S0630
Hypaconitine, an active and highly toxic constituent derived from Aconitum species, has anti-inflammatory activity, is widely used to treat rheumatism.
Gentiopicroside
T2770
Gentiopicroside, a naturally occurring iridoid glycoside, extracted from Gentiana manshurica Kitag, inhibits P450 activity, with an IC50 and a Ki of 61 μM and 22...
Ginsenoside C-K
T3811
Ginsenoside C-K is a bacterial metabolite of G-Rb1 exhibiting anti-inflammatory effects by reducing iNOS and COX-2.
Apigenin
T2175
Chamomile is an aromatic oil extracted from the flowers or leaves of the daisy-like plants. Extracts, oils and teas made from chamomile are used for its soothing...
Miltirone
TN1023
Miltirone is a CYPs inhibitor, it has been characterized as a low-affinity ligand for central benzodiazepine receptors.
Sulfaphenazole
T4567
Sulfaphenazole is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CYP2C8/CYP2C18...
Atazanavir sulfate
T0100
Atazanavir sulfate is an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENTS...
(E)-Flavokawain A
T5715
Flavokavin A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent ap...
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