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Nrf2

Nuclear factor erythroid 2-related factor 2 (NRF2), also known as nuclear factor erythroid-derived 2-like 2, is a transcription factor that in humans is encoded by the NFE2L2 gene. NRF2 is a basic leucine zipper (bZIP) protein that regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation. Several drugs that stimulate the NFE2L2 pathway are being studied for treatment of diseases that are caused by oxidative stress.
Cat. No. Product name CAS No. Purity Chemical Structure
TQ0211 Brusatol 14907-98-3 98%
Brusatol is a natural product isolated from the Brucea javanica plant. It inhibits Nrf2.
T4580 4-Octyl itaconate 3133-16-2 98%
4-Octyl Itaconate is a cell-permeable Itaconate derivative and an anti-inflammatory metabolite. Itaconate activates Nrf2 via alkylation of KEAP1.
T6S1587 Notoginsenoside R2 80418-25-3 98%
Notoginsenoside R2 has neuroprotection against 6-OHDA-induced neurotoxicity, is associated with Notoginsenoside R2-mediated P90RSK and Nrf2 activation through ME...
T4360 ML385 846557-71-9 98%
ML385 is a new-type and selective NRF2 inhibitor.
T13436 (E)-[6]-Dehydroparadol 878006-06-5 98%
(E)-[6]-Dehydroparadol, an oxidative metabolite of [6]-Shogaol, is a potent Nrf2 activator.
T1558 Resveratrol 501-36-0 98%
Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.
T3849 Kinsenoside 151870-74-5 98%
Kinsenoside shows significant antihepatotoxic, and anti-inflammatory activities. Kinsenoside could be useful for repairing beta cells in pancreatic islet injury ...
TN1674 Garcinone D 107390-08-9 98%
Garcinone D shows significant cytotoxicity against the CEM-SS cell line, with IC(50) value of 3.2 microg/ml; it exhibits dose-dependent enzyme-based microsomal a...
T1593 Ezetimibe 163222-33-1 98%
Ezetimibe is a Dietary Cholesterol Absorption Inhibitor. The physiologic effect of ezetimibe is by means of Decreased Cholesterol Absorption.
TN3694 Coniferaldehyde 20649-42-7 98%
Coniferaldehyde can significantly inhibit the growth of viability of strains of Oenococcus oeni. Coniferaldehyde exerts anti-inflammatory properties by inducing ...
TN2336 Rehmapicrogenin 135447-39-1 98%
Rehmapicrogenin regulates the Nrf2/ARE signaling pathway. Nrf2/ARE signaling pathway is the most important pathway of oxidative stress.
TN4160 Goniothalamin 17303-67-2 98%
Goniothalamin induces apoptosis in various cancer cell lines and has gastroprotective activity.
TN4038 Eupatolide 6750-25-0 98%
Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast can...
T9112 (-)-Perillaldehyde 18031-40-8 98%
(-)-Perillaldehyde shows antibacterial activity.
Brusatol
TQ0211
Brusatol is a natural product isolated from the Brucea javanica plant. It inhibits Nrf2.
4-Octyl itaconate
T4580
4-Octyl Itaconate is a cell-permeable Itaconate derivative and an anti-inflammatory metabolite. Itaconate activates Nrf2 via alkylation of KEAP1.
Notoginsenoside R2
T6S1587
Notoginsenoside R2 has neuroprotection against 6-OHDA-induced neurotoxicity, is associated with Notoginsenoside R2-mediated P90RSK and Nrf2 activation through ME...
ML385
T4360
ML385 is a new-type and selective NRF2 inhibitor.
(E)-[6]-Dehydroparadol
T13436
(E)-[6]-Dehydroparadol, an oxidative metabolite of [6]-Shogaol, is a potent Nrf2 activator.
Resveratrol
T1558
Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.
Kinsenoside
T3849
Kinsenoside shows significant antihepatotoxic, and anti-inflammatory activities. Kinsenoside could be useful for repairing beta cells in pancreatic islet injury ...
Garcinone D
TN1674
Garcinone D shows significant cytotoxicity against the CEM-SS cell line, with IC(50) value of 3.2 microg/ml; it exhibits dose-dependent enzyme-based microsomal a...
Ezetimibe
T1593
Ezetimibe is a Dietary Cholesterol Absorption Inhibitor. The physiologic effect of ezetimibe is by means of Decreased Cholesterol Absorption.
Coniferaldehyde
TN3694
Coniferaldehyde can significantly inhibit the growth of viability of strains of Oenococcus oeni. Coniferaldehyde exerts anti-inflammatory properties by inducing ...
Rehmapicrogenin
TN2336
Rehmapicrogenin regulates the Nrf2/ARE signaling pathway. Nrf2/ARE signaling pathway is the most important pathway of oxidative stress.
Goniothalamin
TN4160
Goniothalamin induces apoptosis in various cancer cell lines and has gastroprotective activity.
Eupatolide
TN4038
Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast can...
(-)-Perillaldehyde
T9112
(-)-Perillaldehyde shows antibacterial activity.
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