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NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T79999 NF-κB-IN-13 117596-92-6 98%
NF-κB-IN-13
NF-κB-IN-13 (compound 12) markedly suppresses LPS-induced NF-κB activation and NO synthesis in RAW264.7 macrophages, exhibiting anti-inflammatory properties [1]....
T80062 Mitogen-activated protein kinase 1 137632-08-7 98%
Mitogen-activated protein kinase 1
Mitogen-activated protein kinase 1 (MAPK1) activates the p38/NF-κB pathway and regulates cellular processes in sepsis-associated diseases. Its catalytic action p...
T80208 Tripeptide-41 1093241-16-7 98%
Tripeptide-41
Tripeptide-41 (CG-Lipoxyn) is a bioactive peptide known for its ability to reduce fat accumulation. It has been utilized as an ingredient in cosmetic formulation...
T82022 IVMT-Rx-3 98%
IVMT-Rx-3
IVMT-Rx-3 is a chemical compound that serves as an inhibitor of SDCBP's targeting of the PDZ1 and PDZ2 domains of MDA-9/Syntenin. It effectively blocks the MDA-9...
T82049 IR-Crizotinib 2387927-74-2 98%
IR-Crizotinib
IR-Crizotinib is a conjugate of the near-infrared dye IR-786 and Crizotinib, an NF-κB-inducing kinase (NIK) inhibitor, with an IC50 of 3.381 μM for intracranial ...
T82665 CTP-NBD 1268513-27-4 98%
CTP-NBD
CTP-NBD is a cell-permeable, specific inhibitor of the NFκB peptide, which has been utilized in studies of colitis [1] [2].
T83052 Anti-inflammatory agent 60 98%
Anti-inflammatory agent 60
Anti-inflammatory agent 60 (compound 21) inhibits nitric oxide production, presenting an IC50 of 12.95 μM, and reduces iNOS, phosphorylated p65, and β-catenin ex...
TN4038 Eupatolide 6750-25-0 98%
Eupatolide
Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast can...
TN3587 Capillarisin 56365-38-9 98%
Capillarisin
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
TN1806 Isotetrandrine 477-57-6 98%
Isotetrandrine
Isotetrandrine is a small molecule inhibitor, on various aspects of LPS-induced inflammation in vitro and in vivo. It dose-dependently suppresses the severity of...
TN1485 Chicanine 78919-28-5 98%
Chicanine
Chicanine has anti-inflammatory activity in macrophages by down-regulating LPS-induced inflammatory cytokines in IκBα±/MAPK/ERK signaling pathways.
TN2095 Pomiferin 572-03-2 98%
Pomiferin
Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has a...
TMA1777 Hydrangenol 8-O-glucoside 67600-94-6 98%
Hydrangenol 8-O-glucoside
Hydrangenol 8-O-glucoside may have anti-inflammary activity.
TN3410 Anatabine 581-49-7 98%
Anatabine
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
TN4633 Neocryptotanshinone II 27468-20-8 98%
Neocryptotanshinone II
Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-κB and iNOS signaling pathways.
TN4263 Isoangustone A 129280-34-8 98%
Isoangustone A
Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ...
T4366 Quinovic acid 465-74-7 98%
Quinovic acid
Quinovic acid shows some anti-tumour activities, quinovic acid glycosides have a potent inhibitory effect on the growth of human bladder cancer cell lines by ind...
TN1764 Incensole acetate 34701-53-6 98%
Incensole acetate
Incensole acetate is a novel anti-inflammatory compound that inhibits NF-κB activation.
TN3219 7,8-Didehydrocimigenol 150972-72-8 98%
7,8-Didehydrocimigenol
7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of ...
TN2451 Isosalvianolic acid B 930573-88-9 98%
Isosalvianolic acid B
Isosalvianolic acid B is a natural from Salviae miltiorrhizae
NF-κB-IN-13
T79999
NF-κB-IN-13 (compound 12) markedly suppresses LPS-induced NF-κB activation and NO synthesis in RAW264.7 macrophages, exhibiting anti-inflammatory properties [1]....
Mitogen-activated protein kinase 1
T80062
Mitogen-activated protein kinase 1 (MAPK1) activates the p38/NF-κB pathway and regulates cellular processes in sepsis-associated diseases. Its catalytic action p...
Tripeptide-41
T80208
Tripeptide-41 (CG-Lipoxyn) is a bioactive peptide known for its ability to reduce fat accumulation. It has been utilized as an ingredient in cosmetic formulation...
IVMT-Rx-3
T82022
IVMT-Rx-3 is a chemical compound that serves as an inhibitor of SDCBP's targeting of the PDZ1 and PDZ2 domains of MDA-9/Syntenin. It effectively blocks the MDA-9...
IR-Crizotinib
T82049
IR-Crizotinib is a conjugate of the near-infrared dye IR-786 and Crizotinib, an NF-κB-inducing kinase (NIK) inhibitor, with an IC50 of 3.381 μM for intracranial ...
CTP-NBD
T82665
CTP-NBD is a cell-permeable, specific inhibitor of the NFκB peptide, which has been utilized in studies of colitis [1] [2].
Anti-inflammatory agent 60
T83052
Anti-inflammatory agent 60 (compound 21) inhibits nitric oxide production, presenting an IC50 of 12.95 μM, and reduces iNOS, phosphorylated p65, and β-catenin ex...
Eupatolide
TN4038
Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast can...
Capillarisin
TN3587
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
Isotetrandrine
TN1806
Isotetrandrine is a small molecule inhibitor, on various aspects of LPS-induced inflammation in vitro and in vivo. It dose-dependently suppresses the severity of...
Chicanine
TN1485
Chicanine has anti-inflammatory activity in macrophages by down-regulating LPS-induced inflammatory cytokines in IκBα±/MAPK/ERK signaling pathways.
Pomiferin
TN2095
Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has a...
Hydrangenol 8-O-glucoside
TMA1777
Hydrangenol 8-O-glucoside may have anti-inflammary activity.
Anatabine
TN3410
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
Neocryptotanshinone II
TN4633
Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-κB and iNOS signaling pathways.
Isoangustone A
TN4263
Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ...
Quinovic acid
T4366
Quinovic acid shows some anti-tumour activities, quinovic acid glycosides have a potent inhibitory effect on the growth of human bladder cancer cell lines by ind...
Incensole acetate
TN1764
Incensole acetate is a novel anti-inflammatory compound that inhibits NF-κB activation.
7,8-Didehydrocimigenol
TN3219
7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of ...
Isosalvianolic acid B
TN2451
Isosalvianolic acid B is a natural from Salviae miltiorrhizae
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TargetMol