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NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TN1051 1-Caffeoylquinic acid 1241-87-8 98%
1-Caffeoylquinic acid
1-Caffeoylquinic acid is an important intermediate in lignin biosynthesis. 1-Caffeoylquinic acid has anti-influenza, and antioxidant activities, it also slows th...
T6S1495 Ginsenoside Rk3 364779-15-7 98%
Ginsenoside Rk3
1. Ginsenoside Rk3 and Rh4 could have a role in treating inflammatory diseases. 2. Ginsenoside Rk3 is often used as a major ingredient of the compound preparatio...
T16974 TAK-243 1450833-55-2 98%
TAK-243
TAK-243 (MLN7243) is a small molecule inhibitor of ubiquitin-activating enzyme (UAE ,IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin sig...
T78557 HOIPIN-1 2470242-33-0 98%
HOIPIN-1
HOIPIN-1 (JTP0819958) is a selective and potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) (IC50 >2.8 μM).HOIPIN-1 inhibits LUBAC-mediated NF-k...
T11096 DRI-C21045 2101765-81-3 98%
DRI-C21045
Dri-c21045 showed concentration-dependent inhibition of NF- B activation and all CD40L induced by B cell proliferation. IC50 was 17.1 M and 4.5 M, respectively.D...
T3406 Kuromanin chloride 7084-24-4 98%
Kuromanin chloride
Kuromanin chloride (Chrysontemin chloride) is potent antioxidants and free radical scavengers, may act as modulators of gene regulation and signal transduction p...
T12942L SN50 acetate (213546-53-3 free base) T12942L 98%
SN50 acetate (213546-53-3 free base)
SN50 acetate is a cell permeable inhibitor of NF-κB translocation.
TN3209 3′,4′,7-Trihydroxyflavone  2150-11-0 98%
3′,4′,7-Trihydroxyflavone 
3'4'7-Trihydroxyflavone can markedly inhibit the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone...
TN2089 Platycodin D3 67884-03-1 98%
Platycodin D3
Platycodin D3 is a NF-κB inhibitor, it could as expectorants in diverse inflammatory pulmonary diseases, it can regulate the production and secretion of airway m...
TN1016 Kukoamine A 75288-96-9 98%
Kukoamine A
Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, it also has neuroprotective effects through inhibiting oxidative...
T5795 Suberosin 581-31-7 98%
Suberosin
Suberosin exhibits anti-inflammatory, and anticoagulant activities, it also shows biting deterrent activity against Aedes aegypti, it may be useful for use as mo...
T14491 B022 1202764-53-1 98%
B022
B022 is a selective and potent NF-κB-induced kinase (NIK) inhibitor (Ki: 4.2 nM), a chemical probe for the treatment of liver inflammation and injury.B022 protec...
T0307 Tyloxapol 25301-02-4 98%
Tyloxapol
Tyloxapol (Triton WR1339) is a non-ionic liquid polymer used as a surfactant.
T4S2326 Cornuside 131189-57-6 98%
Cornuside
1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in t...
T35707 3'-Sialyllactose sodium 128596-80-5 98%
3'-Sialyllactose sodium
3'-Sialyllactose sodium is a prebiotic with anti-inflammatory activity that maintains immune homeostasis. 3'-Sialyllactose sodium reduces stressor-induced anxiet...
TWS1977 Kamebakaurin 73981-34-7 98%
Kamebakaurin
1. Kamebakaurin (Kamebakaurine) has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response an...
TN2546 1-Isomangostin 19275-44-6 98%
1-Isomangostin
1-Isomangostin has cytotoxic and anticomplementary activities.
T2878 Ginsenoside Rd 52705-93-8 98%
Ginsenoside Rd
Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors.
TN1067 Galloylpaeoniflorin 122965-41-7 98%
Galloylpaeoniflorin
Galloylpaeoniflorin (6'-O-Galloyl paeoniflorin) may be developed as a cytoprotector against ROS-mediated oxidative stress. Galloylpaeoniflorin is also an inhibti...
T2873 Ginsenoside Rg2 52286-74-5 98%
Ginsenoside Rg2
Ginsenoside Rg2 (Chikusetsusaponin I) is one of the major active components of ginseng, act as an NF-κB inhibitor.
1-Caffeoylquinic acid
TN1051
1-Caffeoylquinic acid is an important intermediate in lignin biosynthesis. 1-Caffeoylquinic acid has anti-influenza, and antioxidant activities, it also slows th...
Ginsenoside Rk3
T6S1495
1. Ginsenoside Rk3 and Rh4 could have a role in treating inflammatory diseases. 2. Ginsenoside Rk3 is often used as a major ingredient of the compound preparatio...
TAK-243
T16974
TAK-243 (MLN7243) is a small molecule inhibitor of ubiquitin-activating enzyme (UAE ,IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin sig...
HOIPIN-1
T78557
HOIPIN-1 (JTP0819958) is a selective and potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) (IC50 >2.8 μM).HOIPIN-1 inhibits LUBAC-mediated NF-k...
DRI-C21045
T11096
Dri-c21045 showed concentration-dependent inhibition of NF- B activation and all CD40L induced by B cell proliferation. IC50 was 17.1 M and 4.5 M, respectively.D...
Kuromanin chloride
T3406
Kuromanin chloride (Chrysontemin chloride) is potent antioxidants and free radical scavengers, may act as modulators of gene regulation and signal transduction p...
SN50 acetate (213546-53-3 free base)
T12942L
SN50 acetate is a cell permeable inhibitor of NF-κB translocation.
3′,4′,7-Trihydroxyflavone 
TN3209
3'4'7-Trihydroxyflavone can markedly inhibit the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone...
Platycodin D3
TN2089
Platycodin D3 is a NF-κB inhibitor, it could as expectorants in diverse inflammatory pulmonary diseases, it can regulate the production and secretion of airway m...
Kukoamine A
TN1016
Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, it also has neuroprotective effects through inhibiting oxidative...
Suberosin
T5795
Suberosin exhibits anti-inflammatory, and anticoagulant activities, it also shows biting deterrent activity against Aedes aegypti, it may be useful for use as mo...
B022
T14491
B022 is a selective and potent NF-κB-induced kinase (NIK) inhibitor (Ki: 4.2 nM), a chemical probe for the treatment of liver inflammation and injury.B022 protec...
Tyloxapol
T0307
Tyloxapol (Triton WR1339) is a non-ionic liquid polymer used as a surfactant.
Cornuside
T4S2326
1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in t...
3'-Sialyllactose sodium
T35707
3'-Sialyllactose sodium is a prebiotic with anti-inflammatory activity that maintains immune homeostasis. 3'-Sialyllactose sodium reduces stressor-induced anxiet...
Kamebakaurin
TWS1977
1. Kamebakaurin (Kamebakaurine) has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response an...
1-Isomangostin
TN2546
1-Isomangostin has cytotoxic and anticomplementary activities.
Ginsenoside Rd
T2878
Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors.
Galloylpaeoniflorin
TN1067
Galloylpaeoniflorin (6'-O-Galloyl paeoniflorin) may be developed as a cytoprotector against ROS-mediated oxidative stress. Galloylpaeoniflorin is also an inhibti...
Ginsenoside Rg2
T2873
Ginsenoside Rg2 (Chikusetsusaponin I) is one of the major active components of ginseng, act as an NF-κB inhibitor.
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TargetMol