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NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.
Cat. No. Product name CAS No. Purity Chemical Structure
T16290 NIK SMI1 1660114-31-7 98%
NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).
T6S0840 Engeletin 572-31-6 98%
1. Engeletin may serve as a potential anti-inflammatory agent. 2. Engeletin possesses potent inhibition of PGE2 release with IC5 values of 19.6 μg/ml. 3. Engelet...
TD0099 Malachite green oxalate 2437-29-8 98%
Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions.
T0307 Tyloxapol 25301-02-4 98%
Tyloxapol is a non-ionic liquid polymer used as a surfactant.
TN5153 Torilin 13018-10-5 98%
Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic...
TN4046 Excisanin A 78536-37-5 98%
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
TN1094 Ginsenoside Rg6 147419-93-0 98%
Ginsenoside Rg6 can inhibit JK cell proliferation in human lymphocytoma and induce its apoptosis, the mechanism may through mitochondrial dysfunction and an incr...
T27034 CL075 256922-53-9 98%
CL075 is a selective TLR8 agonist.CL075 has immunomodulatory activity by triggering the MyD88-dependent signaling pathway, activating NF-κB and IRF7 to elicit th...
T3816 Velutin 25739-41-7 98%
Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well as ...
TN5019 Siegeskaurolic acid 52645-97-3 98%
Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via...
TN3144 6,4'-Dihydroxy-7-methoxyflavanone 189689-32-5 98%
6,4'-Dihydroxy-7-methoxyflavanone is a biologically active compound isolated from the heartwood of Dalbergia odorifera T. Chen (Leguminosae) with antioxidant, an...
TN1598 Dunnianol 139726-29-7 98%
Dunnianol shows anti-inflammatory activity and moderate antibacterial activity.
TN3119 5-Hydroxy-7,8-dimethoxyflavanone 113981-49-0 98%
5-Hydroxy-7,8-dimethoxyflavanone is isolated from Andrographis paniculata Nees. leaves and roots with anti-inflammatory activity.
T21577 Narasin (sodium salt) 58331-17-2 98%
Narasin induces tumor necrosis factor-related apoptosis-induced ligand (TRAIL)-mediated apoptosis by ER stress in glioma cells and inhibits NF-κB signaling by su...
TN4038 Eupatolide 6750-25-0 98%
Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast can...
TN1694 Gliotoxin 67-99-2 98%
Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signalin...
TP1373L Ac2-26 acetate 98%
Ac2-26 acetate is an active N-terminal peptide of annexin A1(AnxA1). Ac2-26 acetate decreases AnxA1 protein expression and inhibits the activation of NF-κB and M...
T7980 Hesperidin methylchalcone 24292-52-2 98%
Hesperidin methylchalcone is the Citrus original products with powerful antioxidant activity. It can suppresse experimental gout arthritis in mice by inhibiting ...
T3775 Armepavine 524-20-9 98%
Armepavine exerted both in vitro and in vivo antifibrotic effects in rats, with inhibition of NF-κB, JunD and C/EBP pathways. It improves experimental autoimmun...
TQ0131 Rocaglamide 84573-16-0 98%
Rocaglamide, isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB act...
NIK SMI1
T16290
NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).
Engeletin
T6S0840
1. Engeletin may serve as a potential anti-inflammatory agent. 2. Engeletin possesses potent inhibition of PGE2 release with IC5 values of 19.6 μg/ml. 3. Engelet...
Malachite green oxalate
TD0099
Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions.
Tyloxapol
T0307
Tyloxapol is a non-ionic liquid polymer used as a surfactant.
Torilin
TN5153
Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic...
Excisanin A
TN4046
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
Ginsenoside Rg6
TN1094
Ginsenoside Rg6 can inhibit JK cell proliferation in human lymphocytoma and induce its apoptosis, the mechanism may through mitochondrial dysfunction and an incr...
CL075
T27034
CL075 is a selective TLR8 agonist.CL075 has immunomodulatory activity by triggering the MyD88-dependent signaling pathway, activating NF-κB and IRF7 to elicit th...
Velutin
T3816
Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well as ...
Siegeskaurolic acid
TN5019
Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via...
6,4'-Dihydroxy-7-methoxyflavanone
TN3144
6,4'-Dihydroxy-7-methoxyflavanone is a biologically active compound isolated from the heartwood of Dalbergia odorifera T. Chen (Leguminosae) with antioxidant, an...
Dunnianol
TN1598
Dunnianol shows anti-inflammatory activity and moderate antibacterial activity.
5-Hydroxy-7,8-dimethoxyflavanone
TN3119
5-Hydroxy-7,8-dimethoxyflavanone is isolated from Andrographis paniculata Nees. leaves and roots with anti-inflammatory activity.
Narasin (sodium salt)
T21577
Narasin induces tumor necrosis factor-related apoptosis-induced ligand (TRAIL)-mediated apoptosis by ER stress in glioma cells and inhibits NF-κB signaling by su...
Eupatolide
TN4038
Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast can...
Gliotoxin
TN1694
Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signalin...
Ac2-26 acetate
TP1373L
Ac2-26 acetate is an active N-terminal peptide of annexin A1(AnxA1). Ac2-26 acetate decreases AnxA1 protein expression and inhibits the activation of NF-κB and M...
Hesperidin methylchalcone
T7980
Hesperidin methylchalcone is the Citrus original products with powerful antioxidant activity. It can suppresse experimental gout arthritis in mice by inhibiting ...
Armepavine
T3775
Armepavine exerted both in vitro and in vivo antifibrotic effects in rats, with inhibition of NF-κB, JunD and C/EBP pathways. It improves experimental autoimmun...
Rocaglamide
TQ0131
Rocaglamide, isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB act...
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