NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.

Cat. No.	Product name	CAS No.	Purity
T5727	CAFESTOL	469-83-0	98%
T5727	CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells....
T0694	Pranlukast	103177-37-3	98%
T0694	Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to...
T3862	Irigenin	548-76-5	98%
T3862	Irigenin has antifungal activity.
T6718	Zingerone	122-48-5	98%
T6718	Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antidiarrhoeic, antilipol...
T6S1966	Curculigoside	85643-19-2	98%
T6S1966	1. Curculigoside can prevent bone loss , improve osteogenesis and inhibit osteoclastogenesis of hAFSCs, suggesting its potential use to regulate hAFSC osteogenic...
T2913	Schisantherin A	58546-56-8	98%
T2913	Schisantherin A is a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra sphenanthera, has been used as an antitussive, tonic, and sedative agent....
T6204	QNZ	545380-34-5	98%
T6204	QNZ (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.
T4S1540	Myrislignan	171485-39-5	98%
T4S1540	Myrislignan has anti-inflammatory, and anti-cancer activities, it inhibited NF-κB signalling pathway activation, inhibited the proliferation of A549 cells in a d...
TN1828	Kahweol	6894-43-5	98%
TN1828	Kahweol has anticarcinogenic, anti-angiogenic,and anti-inflammatory activities, it can block the LPS-induced activation of NF-kappaB by preventing IkappaB degrad...
T12942L	SN50 acetate (213546-53-3 free base)	T12942L	98%
T12942L	SN50 acetate is a cell permeable inhibitor of NF-κB translocation.
TN1244	3'-Demethylnobiletin	112448-39-2	98%
TN1244	3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle a...
TQ0198	Phorbol 12-myristate 13-acetate	16561-29-8	98%
TQ0198	Phorbol 12-myristate 13-acetate (PMA) is a dual SphK and PKC activator.
T7511	Cyclo(his-pro)	53109-32-3	98%
T7511	Cyclo(his-pro) is an endogenous cyclic dipeptide that exerts oxidative damage protection by selectively activating the transcription factor Nrf2 signalling pathw...
TN1141	Isodeoxyelephantopin	38927-54-7	98%
TN1141	Isodeoxyelephantopin exerts antitumor effects on several cancer cells by inducing apoptosis , cell cycle arrest , and inhibiting proliferation. It enhances apopt...
T2768	Saikosaponin A	20736-09-8	98%
T2768	Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-b...
T6485	Embelin	550-24-3	98%
T6485	Embelin, isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).
T6S1495	Ginsenoside Rk3	364779-15-7	98%
T6S1495	1. Ginsenoside Rk3 and Rh4 could have a role in treating inflammatory diseases. 2. Ginsenoside Rk3 is often used as a major ingredient of the compound preparatio...
T0304	Methylthiouracil	56-04-2	98%
T0304	Methylthiouracil is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.
T5798	Euphorbia Factor L2	218916-51-9	98%
T5798	Euphorbiafactor L2 alleviates lipopolysaccharide-induced acute lung injury and inflammation through inhibits NF-κB activation.
T2726	Sinomenine	115-53-7	98%
T2726	Sinomenine is a pure alkaloid isolated from the Sinomenium acutum, is utilized in the treatment of rheumatism and arthritis.