Home Tools
Log in
Cart

NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T5754 Kavain 3155-48-4 98%
Kavain
Kavain, a compound extracted from the Kava plant, Piper methysticum, is found to be involved in TNF-α expression in human and mouse cells via regulation of trans...
T3147 Pyrrolidinedithiocarbamate ammonium 5108-96-3 98%
Pyrrolidinedithiocarbamate ammonium
Pyrrolidinedithiocarbamate ammonium (1-Pyrrolidinedithiocarboxylic acid ammonium salt), a selective NF-κB inhibitor, inhibits translation of nitric oxide synthas...
T6S1141 Ganoderic acid A 81907-62-2 98%
Ganoderic acid A
1. Ganoderic acid A exhibits antitumor activity, mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. 2. Ganode...
T3S0738 Yangonin 500-62-9 98%
yangonin
Yangonin (Y100550) is a novel CB receptor ligand, it exhibits affinity for the human recombinant CB receptor. Yangonin (Y100550) could be a valuable candidate fo...
T3627 IQ-1S free acid 23146-22-7 97.82%
IQ-1S free acid
IQ-1S free acid (IQ-1S) is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity. IQ-1S can reduce inf...
T4S1615 Sanggenon C 80651-76-9 97.76%
Sanggenon C
1. Sanggenon C (Sanggenone C) inhibits tumor cellular proteasomal activity and cell viability, via induction of cell cycle arrest and cell death , inhibiting the...
T4S1658 Benzoyloxypaeoniflorin 72896-40-3 97.64%
Benzoyloxypaeoniflorin
Benzoyloxypaeoniflorin (Benzoyloxypeoniflorin) is a natural product,contributes to improving blood circulation through their inhibitory effects on both platelet ...
T6485 Embelin 550-24-3 97.07%
Embelin
Embelin (Embelic acid), isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).
T1296 4-Aminosalicylic acid 65-49-6 97.07%
4-Aminosalicylic acid
4-Aminosalicylic acid (para-aminosalicylic acid) is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.
T25150 BI-69A11 1233322-09-2 96.97%
BI-69A11
BI-69A11 ((E)-3-(1H-Benzo[d]imidazol-2-yl)-1-(6-chloro-2-hydroxy-4-phenylquinolin-3-yl)prop-2-en-1-one) is a dual AKT and NFkB pathway inhibitor. It enhances the...
T3012 Mangiferin 4773-96-0 96.74%
Mangiferin
Mangiferin (Hedysarid) is used for antidiabetes. Extracted from Mangifera indica L.
T5S0761 Nitidine chloride 13063-04-2 96.59%
Nitidine chloride
1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721...
T3893 Forsythoside B 81525-13-5 96.52%
Forsythoside B
Forsythoside B binds to LPS and reduces the biological activity of serum LPS, and inhibits NF-κB activation. Forsythoside B inhibits the inflammatory response an...
TN1576 Diallyl disulfide 2179-57-9 95%
Diallyl disulfide
Diallyl disulfide has antitumor effect, the effect can be enhanced by miR-200b and miR-22.
T17214 Valencene 4630-07-3 86.9%
Valencene
Valencene (NSC-148969) is a sesquiterpenoid isolated from Cyperus rotundus and is an aroma component of citrus fruits and citrus-derived odors.ValenceneValencene...
T11060 DMAPT 870677-05-7 100.00%
DMAPT
DMAPT (Dimethylamino Parthenolide) is a water-soluble analogue of Parthenolide (PTL). It is an orally active NF-κB inhibitor with an LD50 of 1.7 μM on primary ac...
T6S1572 Sauchinone 177931-17-8 100%
Sauchinone
1. Sauchinone is a useful adjunctive treatment for bacterial infection. 2. Sauchinone, an active lignan found in Saururus chinensis, to regulate the activation o...
T3005 4-Hydroxychalcone 20426-12-4 100%
4-Hydroxychalcone
4-Hydroxychalcone (P-Cinnamoylphenol) attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice.
T10808 CHPG sodium salt 1303993-73-8 100%
CHPG sodium salt
CHPG sodium salt is a selective agonist of mGluR5 and activates the ERK and Akt signaling pathways. CHPG sodium salt can be used in studies about traumatic brain...
TN1117 Veraguensin 19950-55-1 100%
Veraguensin
Veraguensin is derived from Magnolia sp.. Veraguensin inhibits bone resorption and shows high antileishmanial activity.
Kavain
T5754
Kavain, a compound extracted from the Kava plant, Piper methysticum, is found to be involved in TNF-α expression in human and mouse cells via regulation of trans...
Pyrrolidinedithiocarbamate ammonium
T3147
Pyrrolidinedithiocarbamate ammonium (1-Pyrrolidinedithiocarboxylic acid ammonium salt), a selective NF-κB inhibitor, inhibits translation of nitric oxide synthas...
Ganoderic acid A
T6S1141
1. Ganoderic acid A exhibits antitumor activity, mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. 2. Ganode...
yangonin
T3S0738
Yangonin (Y100550) is a novel CB receptor ligand, it exhibits affinity for the human recombinant CB receptor. Yangonin (Y100550) could be a valuable candidate fo...
IQ-1S free acid
T3627
IQ-1S free acid (IQ-1S) is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity. IQ-1S can reduce inf...
Sanggenon C
T4S1615
1. Sanggenon C (Sanggenone C) inhibits tumor cellular proteasomal activity and cell viability, via induction of cell cycle arrest and cell death , inhibiting the...
Benzoyloxypaeoniflorin
T4S1658
Benzoyloxypaeoniflorin (Benzoyloxypeoniflorin) is a natural product,contributes to improving blood circulation through their inhibitory effects on both platelet ...
Embelin
T6485
Embelin (Embelic acid), isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).
4-Aminosalicylic acid
T1296
4-Aminosalicylic acid (para-aminosalicylic acid) is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.
BI-69A11
T25150
BI-69A11 ((E)-3-(1H-Benzo[d]imidazol-2-yl)-1-(6-chloro-2-hydroxy-4-phenylquinolin-3-yl)prop-2-en-1-one) is a dual AKT and NFkB pathway inhibitor. It enhances the...
Mangiferin
T3012
Mangiferin (Hedysarid) is used for antidiabetes. Extracted from Mangifera indica L.
Nitidine chloride
T5S0761
1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721...
Forsythoside B
T3893
Forsythoside B binds to LPS and reduces the biological activity of serum LPS, and inhibits NF-κB activation. Forsythoside B inhibits the inflammatory response an...
Diallyl disulfide
TN1576
Diallyl disulfide has antitumor effect, the effect can be enhanced by miR-200b and miR-22.
Valencene
T17214
Valencene (NSC-148969) is a sesquiterpenoid isolated from Cyperus rotundus and is an aroma component of citrus fruits and citrus-derived odors.ValenceneValencene...
DMAPT
T11060
DMAPT (Dimethylamino Parthenolide) is a water-soluble analogue of Parthenolide (PTL). It is an orally active NF-κB inhibitor with an LD50 of 1.7 μM on primary ac...
Sauchinone
T6S1572
1. Sauchinone is a useful adjunctive treatment for bacterial infection. 2. Sauchinone, an active lignan found in Saururus chinensis, to regulate the activation o...
4-Hydroxychalcone
T3005
4-Hydroxychalcone (P-Cinnamoylphenol) attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice.
CHPG sodium salt
T10808
CHPG sodium salt is a selective agonist of mGluR5 and activates the ERK and Akt signaling pathways. CHPG sodium salt can be used in studies about traumatic brain...
Veraguensin
TN1117
Veraguensin is derived from Magnolia sp.. Veraguensin inhibits bone resorption and shows high antileishmanial activity.
1 ... 16 17 18 ... 21
TargetMol