NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.

Cat. No.	Product name	CAS No.	Purity
TN2100	Pratensein	2284-31-3	99.72%
TN2100	Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.
T25465	GS143	916232-21-8	99.72%
T25465	GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 suppresses NF-κB activation and t...
T0429	Glucosamine	3416-24-8	99.72%
T0429	Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to re...
T0607	Dihydroartemisinin	71939-50-9	99.72%
T0607	Dihydroartemisinin is a metabolite of artemisinin.
TN1691	Glabrol	59870-65-4	99.72%
TN1691	Glabrol is a PTP1B inhibitor, it is also a CYP1B1 inhibitor, it shows inhibition of CYP1B1 in live cell assay with the IC50 value of 15uM.
T5S0993	Kurarinone	34981-26-5	99.72%
T5S0993	Kurarinone, a flavanoid derived from shrub Sophora flavescens,Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong ...
T2733	Sarsasapogenin	126-19-2	99.73%
T2733	Sarsasapogenin is a steroidal sapogenin, that is the aglycosidic portion of a plant saponin. It is named after sarsaparilla (Smilax sp.), a family of climbing pl...
T3913	Saikosaponin D	20874-52-6	99.73%
T3913	Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.
T0468	Lidocaine	137-58-6	99.74%
T0468	Lidocaine is an amide local anesthetic with anti-inflammatory properties in vitro and in vivo. It has this functions perhaps due to an attenuation of intracellul...
T2777	Ginsenoside Rg1	22427-39-0	99.74%
T2777	Ginsenosides are a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng). It improves spatial learning and in...
T2822	Ginsenoside Rb1	41753-43-9	99.74%
T2822	Ginsenoside Rb1 is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.
T3892	Isoacteoside	61303-13-7	99.74%
T3892	Isoacteoside has the anti-inflammatory effect, mediated by action on caspase-1, mitogen-activated protein kinases (c-Jun N-terminal kinase, p38, extracellular si...
T5S1097	Neferine	2292-16-2	99.75%
T5S1097	1. Neferine has anti-tumor activities , Metabolic activation mediated by CYP3A4 and GSH depletion enhanced Neferine-induced cytotoxicity. 2. Neferine can be help...
T3826	Polygalasaponin F	882664-74-6	99.75%
T3826	Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and re...
TN1833	Karacoline	39089-30-0	99.75%
TN1833	Karacolinem is a natural product, reduces degradation of the extracellular matrix (ECM) in intervertebral disc degeneration (IDD) via the NF-κB signaling pathway...
T5701	OPHIOPOGONIN D	945619-74-9	99.75%
T5701	Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.
T2794	Astilbin	29838-67-3	99.76%
T2794	Astilbin is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations.
T2930	α-Lipoic Acid	62-46-4	99.76%
T2930	α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells.α-Lipoi...
T3384	Wedelolactone	524-12-9	99.76%
T3384	Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.
T2873	Ginsenoside Rg2	52286-74-5	99.77%
T2873	Ginsenoside Rg2 is one of the major active components of ginseng, act as an NF-κB inhibitor.