NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.

Cat. No.	Product name	CAS No.	Purity
T17252	WAY-204688	796854-35-8	99.12%
T17252	WAY-204688 is a selective and orally active estrogen receptor inhibitor of NF-κB transcriptional activity (IC50 = 122 nM in HAECT-1 cells).
T6S1538	Neochlorogenic acid	906-33-2	99.12%
T6S1538	(E)-Neochlorogenic Acid is an antioxidant compound used in the treatment of oxidative stress and related afflictions.
T2872	Ginsenoside Re	52286-59-6	99.12%
T2872	Ginsenoside Re may have properties that inhibit or prevent the growth of tumors.
T2878	Ginsenoside Rd	52705-93-8	99.13%
T2878	Ginsenoside Rd may have properties that inhibit or prevent the growth of tumors.
TQ0185	14-Deoxy-11,12-didehydroandrographolide	42895-58-9	99.13%
TQ0185	14-Deoxy-11,12-didehydroandrographolide has hypotensive, anti-inflammatory, anti-asthma, and anti-cancer actions. It can inhibit NF-κB activation.
T2761	Naringin dihydrochalcone	18916-17-1	99.16%
T2761	Naringin Dihydrochalcone(Naringin DC) is an inhibitor of CYP enzymes, used as an artificial sweetener.
TL0016	Sulforaphene	592-95-0	99.19%
TL0016	Sulforaphene is a natural product isolated from radish seeds, exhibits an ED50 against velvetleaf seedlings approximately 2 x 10 -4 M. Sulforaphene promotes canc...
T4S0217	HOMOPLANTAGININ	17680-84-1	99.2%
T4S0217	Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia,it has a protective and therapeutic effect on hepatocyte injury and shows poten...
T16706	Quinoclamine	2797-51-5	99.25%
T16706	Quinoclamine is a naphthoquinone derivative and is an NF-κB inhibitor.
T3860	Isoliquiritin apioside	120926-46-7	99.27%
T3860	Isoliquiritin apioside, isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced act...
T0907	Sulfasalazine	599-79-1	99.28%
T0907	Sulfasalazine is a synthetic salicylic acid derivative with affinity for connective tissues containing elastin and formulated as a prodrug
T16324	Nimbolide	25990-37-8	99.28%
T16324	Nimbolide suppresses CDK4/CDK6 kinase activity. Nimbolide inhibits the NF-κB, Wnt, PI3K-Akt, MAPK, and JAK-STAT signaling pathways. Nimbolide causes apoptosis th...
T2893	Muscone	541-91-3	99.28%
T2893	Muscone is an organic compound that is the primary contributor to the odor of musk.
T5S0754	Isoquercetin	482-35-9	99.29%
T5S0754	1. Isoquercitrin is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercitrin may be as a potential therapeu...
T9105	NF-κB-IN-1	1227098-15-8	99.29%
T9105	NF-κB-IN-1 is a potent NF-κB signaling pathway inhibitor. It is a 4-arylidene crucumin analogue. NF-κB-IN-1 directly inhibits IKK to block NF-κB activation. NF-κ...
T4S1962	Beta-Asarone	5273-86-9	99.32%
T4S1962	1. Beta-Asarone may be a potential preventive drug for Alzheimer's disease. 2. Beta-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in S...
T27012	Chrysotoxine	156951-82-5	99.34%
T27012	Chrysotoxine inhibits 6-hydroxydopamine induced apoptosis in SH-SY5Y cells via NF-κB modulation and mitochondria protection.
T3954	Adelmidrol	1675-66-7	99.35%
T3954	Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid.
T4361	CBL0137 hydrochloride	1197397-89-9	99.35%
T4361	CBL0137 activates p53 and inhibits NF-kB (EC50: 0.37/0.47 μM) in the cell-based p53 and NF-kB reporter assays, respectively. It also suppresses histone chaperone...
T7979	2-Hydroxychalcone	644-78-0	99.38%
T7979	2-Hydroxychalcone can be used as antiparasitic hit compounds when Methoxylated.It can inhibit invasion of triple negative breast cancer cells.