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NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.
Cat. No. Product name CAS No. Purity Chemical Structure
T17252 WAY-204688 796854-35-8 99.12%
WAY-204688 is a selective and orally active estrogen receptor inhibitor of NF-κB transcriptional activity (IC50 = 122 nM in HAECT-1 cells).
T6S1538 Neochlorogenic acid 906-33-2 99.12%
(E)-Neochlorogenic Acid is an antioxidant compound used in the treatment of oxidative stress and related afflictions.
T2872 Ginsenoside Re 52286-59-6 99.12%
Ginsenoside Re may have properties that inhibit or prevent the growth of tumors.
T2878 Ginsenoside Rd 52705-93-8 99.13%
Ginsenoside Rd may have properties that inhibit or prevent the growth of tumors.
TQ0185 14-Deoxy-11,12-didehydroandrographolide 42895-58-9 99.13%
14-Deoxy-11,12-didehydroandrographolide has hypotensive, anti-inflammatory, anti-asthma, and anti-cancer actions. It can inhibit NF-κB activation.
T2761 Naringin dihydrochalcone 18916-17-1 99.16%
Naringin Dihydrochalcone(Naringin DC) is an inhibitor of CYP enzymes, used as an artificial sweetener.
TL0016 Sulforaphene 592-95-0 99.19%
Sulforaphene is a natural product isolated from radish seeds, exhibits an ED50 against velvetleaf seedlings approximately 2 x 10 -4 M. Sulforaphene promotes canc...
T4S0217 HOMOPLANTAGININ 17680-84-1 99.2%
Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia,it has a protective and therapeutic effect on hepatocyte injury and shows poten...
T16706 Quinoclamine 2797-51-5 99.25%
Quinoclamine is a naphthoquinone derivative and is an NF-κB inhibitor.
T3860 Isoliquiritin apioside 120926-46-7 99.27%
Isoliquiritin apioside, isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced act...
T0907 Sulfasalazine 599-79-1 99.28%
Sulfasalazine is a synthetic salicylic acid derivative with affinity for connective tissues containing elastin and formulated as a prodrug
T16324 Nimbolide 25990-37-8 99.28%
Nimbolide suppresses CDK4/CDK6 kinase activity. Nimbolide inhibits the NF-κB, Wnt, PI3K-Akt, MAPK, and JAK-STAT signaling pathways. Nimbolide causes apoptosis th...
T2893 Muscone 541-91-3 99.28%
Muscone is an organic compound that is the primary contributor to the odor of musk.
T5S0754 Isoquercetin 482-35-9 99.29%
1. Isoquercitrin is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercitrin may be as a potential therapeu...
T9105 NF-κB-IN-1 1227098-15-8 99.29%
NF-κB-IN-1 is a potent NF-κB signaling pathway inhibitor. It is a 4-arylidene crucumin analogue. NF-κB-IN-1 directly inhibits IKK to block NF-κB activation. NF-κ...
T4S1962 Beta-Asarone 5273-86-9 99.32%
1. Beta-Asarone may be a potential preventive drug for Alzheimer's disease. 2. Beta-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in S...
T27012 Chrysotoxine 156951-82-5 99.34%
Chrysotoxine inhibits 6-hydroxydopamine induced apoptosis in SH-SY5Y cells via NF-κB modulation and mitochondria protection.
T3954 Adelmidrol 1675-66-7 99.35%
Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid.
T4361 CBL0137 hydrochloride 1197397-89-9 99.35%
CBL0137 activates p53 and inhibits NF-kB (EC50: 0.37/0.47 μM) in the cell-based p53 and NF-kB reporter assays, respectively. It also suppresses histone chaperone...
T7979 2-Hydroxychalcone 644-78-0 99.38%
2-Hydroxychalcone can be used as antiparasitic hit compounds when Methoxylated.It can inhibit invasion of triple negative breast cancer cells.
WAY-204688
T17252
WAY-204688 is a selective and orally active estrogen receptor inhibitor of NF-κB transcriptional activity (IC50 = 122 nM in HAECT-1 cells).
Neochlorogenic acid
T6S1538
(E)-Neochlorogenic Acid is an antioxidant compound used in the treatment of oxidative stress and related afflictions.
Ginsenoside Re
T2872
Ginsenoside Re may have properties that inhibit or prevent the growth of tumors.
Ginsenoside Rd
T2878
Ginsenoside Rd may have properties that inhibit or prevent the growth of tumors.
14-Deoxy-11,12-didehydroandrographolide
TQ0185
14-Deoxy-11,12-didehydroandrographolide has hypotensive, anti-inflammatory, anti-asthma, and anti-cancer actions. It can inhibit NF-κB activation.
Naringin dihydrochalcone
T2761
Naringin Dihydrochalcone(Naringin DC) is an inhibitor of CYP enzymes, used as an artificial sweetener.
Sulforaphene
TL0016
Sulforaphene is a natural product isolated from radish seeds, exhibits an ED50 against velvetleaf seedlings approximately 2 x 10 -4 M. Sulforaphene promotes canc...
HOMOPLANTAGININ
T4S0217
Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia,it has a protective and therapeutic effect on hepatocyte injury and shows poten...
Quinoclamine
T16706
Quinoclamine is a naphthoquinone derivative and is an NF-κB inhibitor.
Isoliquiritin apioside
T3860
Isoliquiritin apioside, isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced act...
Sulfasalazine
T0907
Sulfasalazine is a synthetic salicylic acid derivative with affinity for connective tissues containing elastin and formulated as a prodrug
Nimbolide
T16324
Nimbolide suppresses CDK4/CDK6 kinase activity. Nimbolide inhibits the NF-κB, Wnt, PI3K-Akt, MAPK, and JAK-STAT signaling pathways. Nimbolide causes apoptosis th...
Muscone
T2893
Muscone is an organic compound that is the primary contributor to the odor of musk.
Isoquercetin
T5S0754
1. Isoquercitrin is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercitrin may be as a potential therapeu...
NF-κB-IN-1
T9105
NF-κB-IN-1 is a potent NF-κB signaling pathway inhibitor. It is a 4-arylidene crucumin analogue. NF-κB-IN-1 directly inhibits IKK to block NF-κB activation. NF-κ...
beta-Asarone
T4S1962
1. Beta-Asarone may be a potential preventive drug for Alzheimer's disease. 2. Beta-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in S...
Chrysotoxine
T27012
Chrysotoxine inhibits 6-hydroxydopamine induced apoptosis in SH-SY5Y cells via NF-κB modulation and mitochondria protection.
Adelmidrol
T3954
Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid.
CBL0137 hydrochloride
T4361
CBL0137 activates p53 and inhibits NF-kB (EC50: 0.37/0.47 μM) in the cell-based p53 and NF-kB reporter assays, respectively. It also suppresses histone chaperone...
2-Hydroxychalcone
T7979
2-Hydroxychalcone can be used as antiparasitic hit compounds when Methoxylated.It can inhibit invasion of triple negative breast cancer cells.
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