NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.

Cat. No.	Product name	CAS No.	Purity
T3S1692	Octahydrocurcumin	36062-07-4	99.54%
T3S1692	Octahydrocurcumin has antioxidant and and anti-inflammatory activities, it can inhibit the lipopolysaccharide (LPS)-induced inflammatory response via the mechani...
TN4220	Homobutein	34000-39-0	99.50%
TN4220	Homobutein (3-O-Methylbutein) is a dual inhibitor of HDACs and NF-κB with IC50s of 190 and 38 μM. Homobutein is an iron chelator with anticancer, anti-inflammato...
T3S1775	Tectochrysin	520-28-5	99.49%
T3S1775	1. Tectochrysin (Techtochrysine) has antioxidant effect. 2. Tectochrysin is promising inhibitors for the reversal of ABCG2-mediated drug transport. 3. Tectochrys...
T16290	NIK SMI1	1660114-31-7	99.48%
T16290	NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).
TN1410	Asperulosidic acid	25368-11-0	99.47%
TN1410	Asperulosidic acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-...
T17309	(R)-(-)-Ibuprofen	51146-57-7	99.47%
T17309	(R)-(-)-Ibuprofen ((R)-Ibuprofen) is the R enantiomer of Ibuprofen and inhibits NF-κB activation. (R)-(-)-Ibuprofen has anti-inflammatory and antinociceptive eff...
TN1035	Irisolidone	2345-17-7	99.46%
TN1035	Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.
T77582	Anti-inflammatory agent 51	2911610-03-0	99.46%
T77582	Anti-inflammatory agent 51 is an amide/sulfonamide derivative with anti-inflammatory and potentially anti-tumor activity and inhibition of NF-κB activation, whic...
T6027	Delanzomib	847499-27-8	99.46%
T6027	Delanzomib (CEP-18770) is an orally active inhibitor of the chymotrypsin-like activity of proteasome (IC50: 3.8 nM). It only marginally inhibits the tryptic and ...
T6S0659	Rhynchophylline	76-66-4	99.44%
T6S0659	1. Rhynchophylline (Mitrinermine) can protect against ischemic damage, probably via regulating the Akt/mTOR pathway. 2. Rhynchophylline can protect against gluta...
T3662	Eleutheroside E	39432-56-9	99.43%
T3662	Eleutheroside E has anti-inflammatory effects by inhibiting NF-κB activities. Eleutheroside E significantly decreases the inflammatory cell infiltration, pannus ...
TN2008	Okanin	484-76-4	99.4%
TN2008	Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.
T2920	Berbamine dihydrochloride	6078-17-7	99.38%
T2920	Berbamine dihydrochloride (Berbamine), a natural compound derived from the Berberis amurensis plant, has been shown to exhibit antitumor activity in several Ys.
T6S0119	Dauricine	524-17-4	99.38%
T6S0119	1. Dauricine has pulmonary toxicity, can produce pulmonary injury in CD-1 mice by the metabolism of Dauricine mediated by CYP3A. 2. Dauricinec can pass the blood...
T7979	2-Hydroxychalcone	644-78-0	99.38%
T7979	2-Hydroxychalcone (2-(2-Hydroxybenzal)Acetophenone) can be used as antiparasitic hit compounds when Methoxylated.It can inhibit invasion of triple negative breas...
T3954	Adelmidrol	1675-66-7	99.35%
T3954	Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid.
TN1620	Eriocalyxin B	84745-95-9	99.35%
TN1620	Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a cand...
T27012	Chrysotoxine	156951-82-5	99.34%
T27012	Chrysotoxine (Phenol, 4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxy-) inhibits 6-hydroxydopamine induced apoptosis in SH-SY5Y cells via NF-κB modulation and mit...
T2140	Parthenolide	20554-84-1	99.33%
T2140	(-)-Parthenolide ((-)-Parthenolide), an inhibitor of the Nuclear Factor-κB Pathway, also promotes the ubiquitination of MDM2 and activates p53 cellular functions...
TN4234	Hydrangenol	480-47-7	99.33%
TN4234	Hydrangenol is a natural product and can be isolated from Hydrangea serrata leaves. Hydrangenol is an antiphotoaging compound with oral activity. Hydrangenol can...