T1798 |
RITA
|
213261-59-7
|
98.85%
|
|
RITA(NSC 652287) induced cross-links of both DNA-DNA and DNA-protein with no detectable DNA single-strand breaks. RITA, like nutlin-3, can disrupt the p53/Mdm2 i...
|
T3517 |
RO8994
|
1309684-94-3
|
98.87%
|
|
RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding ...
|
TQ0231 |
NVP-CGM097
|
1313363-54-0
|
98.92%
|
|
NVP-CGM097 is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2).
|
T21773 |
SP-141
|
1253491-42-7
|
99.21%
|
|
SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity.
|
T1919 |
Tenovin-1
|
380315-80-0
|
99.44%
|
|
Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.
|
T6254 |
Idasanutlin
|
1229705-06-9
|
99.55%
|
|
Idasanutlin (RG-7388) is an effective and specific p53-MDM2 inhibitor (IC50: 6 nM).
|
T3653 |
MX69
|
1005264-47-0
|
99.78%
|
|
MX69 is the MDM2/XIAP inhibitor, blocking the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation.
|
T16888 |
SJ-172550
|
431979-47-4
|
99.87%
|
|
SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).
|
T6965 |
RG7112
|
939981-39-2
|
99.9%
|
|
RG7112 (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor.
|
T3184 |
Kevetrin hydrochloride
|
66592-89-0
|
99.93%
|
|
Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.
|
T6610 |
NSC-207895
|
58131-57-0
|
98%
|
|
NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
|
T21578 |
NSC 66811
|
6964-62-1
|
|
|
NSC 66811is a novel inhibitor of the murine double minute 2 (MDM2)-p53 interaction. It binds to MDM2 with a Ki of 120 nM and activates p53 in cancer cells with a...
|