Mdm2

Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene. Mdm2 is an important negative regulator of the p53 tumor suppressor. Mdm2 protein functions both as an E3 ubiquitin ligase that recognizes the N-terminal trans-activation domain (TAD) of the p53 tumor suppressor and as an inhibitor of p53 transcriptional activation.

Cat. No.	Product name	CAS No.	Purity
T1798	RITA	213261-59-7	98.85%
T1798	RITA(NSC 652287) induced cross-links of both DNA-DNA and DNA-protein with no detectable DNA single-strand breaks. RITA, like nutlin-3, can disrupt the p53/Mdm2 i...
T3517	RO8994	1309684-94-3	98.87%
T3517	RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding ...
TQ0231	NVP-CGM097	1313363-54-0	98.92%
TQ0231	NVP-CGM097 is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2).
T21773	SP-141	1253491-42-7	99.21%
T21773	SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity.
T1919	Tenovin-1	380315-80-0	99.44%
T1919	Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.
T6254	Idasanutlin	1229705-06-9	99.55%
T6254	Idasanutlin (RG-7388) is an effective and specific p53-MDM2 inhibitor (IC50: 6 nM).
T3653	MX69	1005264-47-0	99.78%
T3653	MX69 is the MDM2/XIAP inhibitor, blocking the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation.
T16888	SJ-172550	431979-47-4	99.87%
T16888	SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).
T6965	RG7112	939981-39-2	99.9%
T6965	RG7112 (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor.
T3184	Kevetrin hydrochloride	66592-89-0	99.93%
T3184	Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.
T6610	NSC-207895	58131-57-0	98%
T6610	NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
T21578	NSC 66811	6964-62-1
T21578	NSC 66811is a novel inhibitor of the murine double minute 2 (MDM2)-p53 interaction. It binds to MDM2 with a Ki of 120 nM and activates p53 in cancer cells with a...