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MAO

Monoamine oxidases (MAO) are a family of enzymes that catalyze the oxidation of monoamines, employing oxygen to clip off their amine group. They are found bound to the outer membrane of mitochondria in most cell types of the body. MAOs are important in the breakdown of monoamines ingested in food, and also serve to inactivate monoamine neurotransmitters. Because of the latter, they are involved in a number of psychiatric and neurological diseases, some of which can be treated with monoamine oxidase inhibitors (MAOIs) which block the action of MAOs.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TN7057 Rosmarinate acid 537-15-5 99.00%
rosmarinate acid
Rosmarinate acid(Rosemary acid) inhibits MAO-A, MAO-B and COMT enzymes with IC50s of 50.1, 184.6 and 26.7 μM, respectively
T32535 Ladostigil 209394-27-4 98.79%
Ladostigil
Ladostigil (Ladostigil free base) is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO) with inhibitory effects on MAO...
T0418 Allylthiourea 109-57-9 98.71%
Allylthiourea
Allylthiourea (Thiosinamine), a metabolic inhibitor, specifically suppresses ammonia oxidation.
T3933 Jatrorrhizine 3621-38-3 98.59%
Jatrorrhizine
Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and ant...
T6651 Safinamide mesylate 202825-46-5 98.41%
Safinamide mesylate
Safinamide mesylate (EMD 1195686 mesylate) , a mesylate salt of Safinamide, can reversibly and specifically inhibit MAO-B (IC50: 98 nM), has 5918-fold selectivit...
TN1120 Osthenol 484-14-0 98.33%
Osthenol
Osthenol is a natural product, and is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 µM).It shows antitumor-promoti...
T24680 PSB-1491 1619884-67-1 98.29%
PSB-1491
PSB-1491 is a selective and competitive monoamine oxidase B inhibitor with IC50 of 0.386 nM, >25000-fold selective versus MAO-A.
T27606 Indantadol HCl 202914-18-9 98.24%
Indantadol HCl
Indantadol HCl (CHF-3381) is a NMDA antagonist and nonselective MAO inhibitor.
T2765 Rosmarinic acid 20283-92-5 98.19%
Rosmarinic acid
Rosmarinic acid (Labiatenic acid) is widely found in plants and has antioxidant, anti-inflammatory, and antibacterial activities. It inhibits MAO-A, MAO-B, and C...
T60932 MAO-B-IN-8 1638956-60-1 98.19%
MAO-B-IN-8
MAO-B-IN-8 is a highly potent and reversible inhibitor of monoamine oxidase-B (MAO-B), which also exhibits inhibitory effects on the microglial production of neu...
T77578 CHBO4 98991-32-3 98.14%
CHBO4
CHBO4 is an hMAO-B inhibitor that is potent, reversible, competitive and selective.The IC50 value of CHBO4 against hMAO-B in the CHBO assay was 0.031 μM, and the...
T5887 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone 22246-18-0 98%
7-Hydroxy-3,4-dihydro-2(1H)-quinolinone
7-Hydroxy-3,4-dihydro-2(1H)-quinolinone is a weak MAO-A inhibitor(with an IC50 of 183 μM) .
T5648 Purpurin 81-54-9 98%
Purpurin
Purpurin (Verantin) was a reversible and competitive inhibitor of MAO-A with a Ki value of 0.422μM. it exhibits anti-angiogenic, antifungal, antibiotic, and anti...
T1025 Tranylcypromine (2-PCPA) hydrochloride 1986-47-6 97.19%
Tranylcypromine (2-PCPA) hydrochloride
Tranylcypromine (2-PCPA) hydrochloride (SKF-385 HCl), a Monoamine Oxidase inhibitor, is effective in the treatment of major depression, dysthymic disorder, and a...
T10146 4-Hydroxyderricin 55912-03-3 97.02%
4-Hydroxyderricin
4-Hydroxyderricin, a potent and selective MAO-B inhibitor (IC50: 3.43 μM), is the main active ingredient of Angelica sinensis, which mildly inhibits dopamine β-h...
T16803 RS 8359 105365-76-2 96.03%
RS 8359
RS 8359 is a reversible inhibitor of monoamine oxidase A (MAO-A) with a selectivity ratio of about 2200 for the A:B enzyme types. RS 8359 has antidepressant acti...
T0966 Sennoside A 81-27-6 95.95%
Sennoside A
Sennoside A (NSC-112929), a kind of irritant laxative isolated from rhei rhizome, causes purgative actions in the intestine.
T50055 Milacemide 76990-56-2 95.00%
Milacemide
Milacemide is a glycine prodrug and MAO-B inhibitor. Milacemide has been studied for its effects on human memory and as a potential treatment for the symptoms of...
T1455 Nialamide 51-12-7 93.91%
Nialamide
Nialamide (Nialamid) is an MAO inhibitor that is used as an antidepressive agent.
T26632 AnnH31 241809-12-1 100%
AnnH31
AnnH31 is a potent Dyrk1A inhibitor with an IC50 value of 81 nM.AnnH31 inhibits MAO-A with an IC50 of 3.2 μM.AnnH31 can be used as a probe to confirm the involve...
rosmarinate acid
TN7057
Rosmarinate acid(Rosemary acid) inhibits MAO-A, MAO-B and COMT enzymes with IC50s of 50.1, 184.6 and 26.7 μM, respectively
Ladostigil
T32535
Ladostigil (Ladostigil free base) is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO) with inhibitory effects on MAO...
Allylthiourea
T0418
Allylthiourea (Thiosinamine), a metabolic inhibitor, specifically suppresses ammonia oxidation.
Jatrorrhizine
T3933
Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and ant...
Safinamide mesylate
T6651
Safinamide mesylate (EMD 1195686 mesylate) , a mesylate salt of Safinamide, can reversibly and specifically inhibit MAO-B (IC50: 98 nM), has 5918-fold selectivit...
Osthenol
TN1120
Osthenol is a natural product, and is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 µM).It shows antitumor-promoti...
PSB-1491
T24680
PSB-1491 is a selective and competitive monoamine oxidase B inhibitor with IC50 of 0.386 nM, >25000-fold selective versus MAO-A.
Indantadol HCl
T27606
Indantadol HCl (CHF-3381) is a NMDA antagonist and nonselective MAO inhibitor.
Rosmarinic acid
T2765
Rosmarinic acid (Labiatenic acid) is widely found in plants and has antioxidant, anti-inflammatory, and antibacterial activities. It inhibits MAO-A, MAO-B, and C...
MAO-B-IN-8
T60932
MAO-B-IN-8 is a highly potent and reversible inhibitor of monoamine oxidase-B (MAO-B), which also exhibits inhibitory effects on the microglial production of neu...
CHBO4
T77578
CHBO4 is an hMAO-B inhibitor that is potent, reversible, competitive and selective.The IC50 value of CHBO4 against hMAO-B in the CHBO assay was 0.031 μM, and the...
7-Hydroxy-3,4-dihydro-2(1H)-quinolinone
T5887
7-Hydroxy-3,4-dihydro-2(1H)-quinolinone is a weak MAO-A inhibitor(with an IC50 of 183 μM) .
Purpurin
T5648
Purpurin (Verantin) was a reversible and competitive inhibitor of MAO-A with a Ki value of 0.422μM. it exhibits anti-angiogenic, antifungal, antibiotic, and anti...
Tranylcypromine (2-PCPA) hydrochloride
T1025
Tranylcypromine (2-PCPA) hydrochloride (SKF-385 HCl), a Monoamine Oxidase inhibitor, is effective in the treatment of major depression, dysthymic disorder, and a...
4-Hydroxyderricin
T10146
4-Hydroxyderricin, a potent and selective MAO-B inhibitor (IC50: 3.43 μM), is the main active ingredient of Angelica sinensis, which mildly inhibits dopamine β-h...
RS 8359
T16803
RS 8359 is a reversible inhibitor of monoamine oxidase A (MAO-A) with a selectivity ratio of about 2200 for the A:B enzyme types. RS 8359 has antidepressant acti...
Sennoside A
T0966
Sennoside A (NSC-112929), a kind of irritant laxative isolated from rhei rhizome, causes purgative actions in the intestine.
Milacemide
T50055
Milacemide is a glycine prodrug and MAO-B inhibitor. Milacemide has been studied for its effects on human memory and as a potential treatment for the symptoms of...
Nialamide
T1455
Nialamide (Nialamid) is an MAO inhibitor that is used as an antidepressive agent.
AnnH31
T26632
AnnH31 is a potent Dyrk1A inhibitor with an IC50 value of 81 nM.AnnH31 inhibits MAO-A with an IC50 of 3.2 μM.AnnH31 can be used as a probe to confirm the involve...
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