T79746 |
LRRK2-IN-10
|
2704562-80-9
|
98%
|
|
LRRK2-IN-10 (compound 34) is a potent, mutation-selective, brain-penetrant inhibitor targeting G2019S-LRRK2 kinase with IC50 values of 11 nM for G2019S-LRRK2 pS9...
|
T81785 |
MK-1468
|
2769107-89-1
|
98%
|
|
MK-1468, a highly selective and brain-penetrant LRRK2 inhibitor, exhibits an IC50 of 0.8 nM and is utilized in the study of Parkinson's disease [1].
|
T2014 |
CCG-1423
|
285986-88-1
|
99.98%
|
|
CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.
|
T6031 |
GNE0877
|
1374828-69-9
|
99.96%
|
|
GNE0877 (GNE 0877) is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM).
|
T2240 |
GSK2578215A
|
1285515-21-0
|
99.81%
|
|
GSK2578215A is a potent and selective LRRK2 kinase inhibitor.
|
T16512 |
PFE-360
|
1527475-61-1
|
99.73%
|
|
PFE-360 (PF-06685360) is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo).
|
T11878 |
LRRK2 inhibitor 1
|
1802525-61-6
|
99.73%
|
|
LRRK2 inhibitor 1 is a selective and potent LRRK2 inhibitor with an IC50 of 13 nM.LRRK2 inhibitor 1 inhibits DCLK1 kinase with an IC50 value of 2.61 nM.
|
T2050 |
PF-06447475
|
1527473-33-1
|
99.62%
|
|
PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.
|
T6176 |
IKK 16
|
873225-46-8
|
99.61%
|
|
IKK 16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
|
T2022 |
CZC-54252
|
1191911-27-9
|
99.39%
|
|
CZC-54252 is a potent inhibitor of LRRK2.
|
T16115 |
MLi-2
|
1627091-47-7
|
99.33%
|
|
MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a ...
|
T5139 |
CZC-25146 hydrochloride
|
1330003-04-7
|
99.06%
|
|
CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.
|
T2246 |
LRRK2-IN-1
|
1234480-84-2
|
98.44%
|
|
LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.
|
T39202 |
CZC-54252 hydrochloride
|
1784253-05-9
|
98.21%
|
|
CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2. CZC-54252 hydrochloride has a neuropr...
|
T3053 |
CZC-25146
|
1191911-26-8
|
98.2%
|
|
CZC-25146 (CHEMBL2397014) is an effective, specific and metabolically stable LRRK2 inhibitor with IC50 of 4.76/6.87 nM for wild-type LRRK2(Leucine-rich repeat ki...
|
T1945 |
GNE-7915
|
1351761-44-8
|
98%
|
|
GNE-7915 is a highly potent, selective and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor.
|
T7729 |
PF-06454589
|
1527473-30-8
|
96.29%
|
|
PF-06454589 is a potent inhibitor of LRRK2.
|
T1770 |
GNE-9605
|
1536200-31-3
|
98%
|
|
GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).
|
T7155 |
JH-II-127
|
1700693-08-8
|
98%
|
|
JH-II-127 is an orally inhibitor of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, G2019S LRRK2 and A2016T LRRK2 (IC50s = 6.6, 2.2, and 47.7 nM, re...
|
T7196 |
HG-10-102-01
|
1351758-81-0
|
98%
|
|
HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).
|