TN5153 |
Torilin
|
13018-10-5
|
98%
|
|
Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic...
|
TMA1004 |
Lucidenic acid F
|
98665-18-0
|
98%
|
|
Lucidenic acid F as a modulator of JNK and p38, it shows potent inhibitory effects on EBV-EA induction.
|
TN2895 |
3,5-Dicaffeoyl-epi-quinic acid
|
879305-14-3
|
98%
|
|
3,5-Dicaffeoyl-epi-quinic acid shows anti-inflammatory activity, it may improve mast cell-mediated inflammatory diseases.
|
TN4107 |
Ganoderic acid X
|
86377-53-9
|
98%
|
|
Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
|
TN1072 |
Lappaol A
|
62333-08-8
|
98%
|
|
Lappaol A has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol A also ...
|
TN3806 |
Dehydroglyasperin C
|
199331-35-6
|
98%
|
|
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemop...
|
TMA0507 |
Tomatidine
|
77-59-8
|
99.98%
|
|
Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. It activates autophagy either in mammal cells or C elegans.
|
T3876 |
Loureirin B
|
119425-90-0
|
99.91%
|
|
Loureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress...
|
TN1677 |
Gartanin
|
33390-42-0
|
99.85%
|
|
Gartanin is an androgen receptor degradation enhancer, it is also a potential neuroprotective agent against glutamate-induced oxidative injury partially through ...
|
T16927 |
SR-3306
|
1128096-91-2
|
99.81%
|
|
SR-3306 is a potent and highly inhibitor of brain penetrant JNK.
|
T2872 |
Ginsenoside Re
|
52286-59-6
|
99.78%
|
|
Ginsenoside Re (Ginsenoside B2) may have properties that inhibit or prevent the growth of tumors.
|
T6758 |
Anisomycin
|
22862-76-6
|
99.66%
|
|
Anisomycin (NSC-76712) is an antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transfera...
|
TN1557 |
Decursinol angelate
|
130848-06-5
|
99.65%
|
|
Decursinol angelate has anti-tumor, anti-inflammatory, anti-oxidant, and hepatoprotective activities, it inhibits VEGF-induced angiogenesis via suppression of th...
|
T13265 |
Urolithin B
|
1139-83-9
|
99.64%
|
|
Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropical frui...
|
T3079 |
GSK1838705A
|
1116235-97-2
|
99.63%
|
|
GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to ...
|
T2035 |
WHI-P258
|
21561-09-1
|
99.59%
|
|
WHI-P258 is a dimethoxyquinazoline inhibitor of JAK3. This compound binds JAK3 weakly and may be used as a JAK-binding negative control in the development of new...
|
T3598 |
JNK-IN-7
|
1408064-71-0
|
99.58%
|
|
JNK-IN-7 (JNK inhibitor) is a selective JNK1/2/3 inhibitor (IC50: 1.54/1.99/0.75 nM). It can also inhibit phosphorylation of c-Jun, which is a substrate of JNK k...
|
T3109 |
SP600125
|
129-56-6
|
99.58%
|
|
SP600125 (JNK Inhibitor II) is a JNK1/2/3 inhibitor (IC50: 40/40/90 nM) and 10-fold higher selectivity than MKK4, 25-fold higher selectivity than MKK3, MKK6, PKC...
|
T10937L |
D-JNKI-1 acetate
|
|
99.48%
|
|
D-JNKI-1 acetate (AM-111 acetate) is a highly potent and cell-permeable peptide inhibitor of JNK.
|
T3895 |
Polyphyllin I
|
50773-41-6
|
99.36%
|
|
Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, c...
|