IκB/IKK

The IκB kinase (IKK) is an enzyme complex that is involved in propagating the cellular response to inflammation.The IκB kinase enzyme complex is part of the upstream NF-κB signal transduction cascade. The IκBα (inhibitor of nuclear factor kappa B) protein inactivates the NF-κB transcription factor by masking the nuclear localization signals (NLS) of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm. Specifically, IKK phosphorylates the inhibitory IκBα protein. This phosphorylation results in the dissociation of IκBα from NF-κB. NF-κB, which is now free, migrates into the nucleus and activates the expression of at least 150 genes; some of which are anti-apoptotic.

Cat. No.	Product name	CAS No.	Purity
TQ0306	MLN120B	783348-36-7	98.86%
TQ0306	MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM).
T6186	TRAM-34	289905-88-0	99.01%
T6186	TRAM-34(Kd=20 nM), an effective and specific inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1), does not block cytochrome P450....
T6165	Bardoxolone Methyl	218600-53-4	99.09%
T6165	Bardoxolone Methyl, an IKK inhibitor, exhibits effective proapoptotic and anti-inflammatory activities.
T6326	BMS-345541	445430-58-0	99.29%
T6326	BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.
T3049	TPCA-1	507475-17-4	99.29%
T3049	TPCA-1 is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM); shows >22-fold selectivity over IKK-1 and >550-fold selectivity over others kinases and enzy...
T9105	NF-κB-IN-1	1227098-15-8	99.29%
T9105	NF-κB-IN-1 is a potent NF-κB signaling pathway inhibitor. It is a 4-arylidene crucumin analogue. NF-κB-IN-1 directly inhibits IKK to block NF-κB activation. NF-κ...
T10477	BAY-985	2409479-29-2	99.3%
T10477	BAY-985 is a potent, selective, and orally active ATP-competitive dual inhibitor of TBK1 and IKKε (IC50s: 2/30 and 2 nM for TBK1 (low/high ATP) and IKKε) with an...
T6771	AZD3264	1609281-86-8	99.42%
T6771	AZD3264 is a new type IKK2 inhibitor.
T1934	Bay 11-7085	196309-76-9	99.43%
T1934	BAY 11-7085 can irreversibly inhibit the IκBα phosphorylation induced by TNFα (IC50: 10 μM).
T8910	2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC	4815-35-4	99.44%
T8910	2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC is Inhibitior of IKKβ.
T1639	Amlexanox	68302-57-8	99.56%
T1639	Amlexanox is an anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, from mast...
T1830	BX795	702675-74-9	99.57%
T1830	BX795 is an effective and selective PDK1 inhibitor (IC50: 6 nM), and its selectivity is 140- and 1600-fold for PDK1 over PKA and PKC in cell-free assays, respect...
T6176	IKK 16	873225-46-8	99.61%
T6176	IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
T3094	PS-1145	431898-65-6	99.63%
T3094	PS-1145 is a specific IKK inhibitor with IC50 of 88 nM.
T7081	CCCP	555-60-2	99.64%
T7081	CCCP inhibits activation of STING and its downstream signalling molecules, TBK1 and IRF3. CCCP inhibits STING-mediated IFN-β production via disrupting mitochondr...
T6141	IMD-0354	978-62-1	99.65%
T6141	IMD-0354 is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway.
T25465	GS143	916232-21-8	99.72%
T25465	GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 suppresses NF-κB activation and t...
T5S0993	Kurarinone	34981-26-5	99.72%
T5S0993	Kurarinone, a flavanoid derived from shrub Sophora flavescens,Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong ...
T2765	Rosmarinic acid	20283-92-5	99.73%
T2765	Rosmarinic acid has shown to contain antioxidant, anti-inflammatory and antimicrobial activities. Possesses promising physiological actions related to cognitive ...
T3736	Olivetol	500-66-3	99.74%
T3736	Olivetol (5-pentylresorcinol, 5-pentyl-1,3-benzenediol) is an organic compound found in certain species of lichen; it is also a precursor in various syntheses of...