Hedgehog/Smoothened

The Hedgehog signaling pathway is a signaling pathway that transmits information to embryonic cells required for proper cell differentiation. Different parts of the embryo have different concentrations of hedgehog signaling proteins. The pathway also has roles in the adult. Diseases associated with the malfunction of this pathway include basal cell carcinoma.

Cat. No.	Product name	CAS No.	Purity
T1810	Purmorphamine	483367-10-8	99.48%
T1810	Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is an inducer of osteoblast differentiation.
T2825	Cyclopamine	4449-51-8	99.66%
T2825	Cyclopamine, a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids.
T2299	BMS-833923	1059734-66-5	99.74%
T2299	BMS-833923, an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM).
T0465	Ellagic acid	476-66-4	99.76%
T0465	Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clott...
T2450	SANT-1	304909-07-7	99.84%
T2450	SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM).
T1543	Naftifine hydrochloride	65473-14-5	99.84%
T1543	Naftifine Hydrochloride is the hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum antifungal activity. Although the exact...
T3363	Jervine	469-59-0	99.86%
T3363	The biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened...
T15370	GANT 58	64048-12-0	99.88%
T15370	GANT 58 is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 μM).
T1011	Itraconazole	84625-61-6	99.97%
T1011	Itraconazole is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.
T1926	Sonidegib	956697-53-3	99.97%
T1926	LDE225 (NVP-LDE225; Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.
T2590	Vismodegib	879085-55-9	99.99%
T2590	Vismodegib is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).
T15183	Dynarrestin	2222768-84-3	98%
T15183	Dynarrestin is an inhibitor of cytoplasmic dyneins 1 and 2. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells. ...