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Hedgehog/Smoothened

The Hedgehog signaling pathway is a signaling pathway that transmits information to embryonic cells required for proper cell differentiation. Different parts of the embryo have different concentrations of hedgehog signaling proteins. The pathway also has roles in the adult. Diseases associated with the malfunction of this pathway include basal cell carcinoma.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T2825 Cyclopamine 4449-51-8 98.55%
Cyclopamine
Cyclopamine (11-Deoxojervine), a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids.
T1810 Purmorphamine 483367-10-8 98.11%
Purmorphamine
Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is an inducer of os...
T3070 GANT 61 500579-04-4 98%
GANT 61
GANT 61 (GANT61) is an inhibitor for Gli1 and Gli2.
T6514 Glasdegib 1095173-27-5 98%
Glasdegib
Glasdegib (PF-04449913) (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.
T15019 CUR61414 334998-36-6 97.34%
CUR61414
CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM).
T3156 Ciliobrevin A 302803-72-1 97.10%
Ciliobrevin A
Ciliobrevin A (HPI-4) is an inhibitor of hedgehog signaling pathway with an IC50 <10 μM.
T15019L CUR61414 hydrochloride 95.22%
CUR61414  hydrochloride
CUR61414 hydrochloride is a potent and cell permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM). CUR61414 hydrochloride is a small-molecule amin...
T22089 HPI 1 599150-20-6 94.4%
HPI 1
HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5...
T23370 SMANT hydrochloride 1177600-74-6 100%
SMANT hydrochloride
SMANT hydrochloride (N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride) is an antagonist of Smoothened accumulation.
T14965 Ciliobrevin D 1370554-01-0 100%
Ciliobrevin D
Ciliobrevin D is a AAA+ ATPase motor cytoplasmic dynein inhibitor. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation and it also inhibit...
T1011 Itraconazole 84625-61-6 100%
Itraconazole
Itraconazole (R51211) is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.
T40465 SAG dihydrochloride 2702366-44-5 100%
SAG dihydrochloride
SAG dihydrochloride, a powerful agonist of the Smoothened (Smo) receptor (EC 50 = 3 nM; Kd = 59 nM), effectively activates the Hedgehog signaling pathway. It als...
T1094 Tolnaftate 2398-96-1 100%
Tolnaftate
Tolnaftate (NP-27) is a synthetic antifungal agent.
T4211 SAG hydrochloride (912545-86-9(free base)) 2095432-58-7
SAG hydrochloride (912545-86-9(free base))
SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist.
T3460 HhAntag 496794-70-8
HhAntag
HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity....
T2666 Taladegib 1258861-20-9 98%
Taladegib
Taladegib (LY2940680) is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antin...
T22814 GSA-10 300833-95-8 98%
GSA-10
Smoothened (Smo) receptor agonist
Cyclopamine
T2825
Cyclopamine (11-Deoxojervine), a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids.
Purmorphamine
T1810
Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is an inducer of os...
GANT 61
T3070
GANT 61 (GANT61) is an inhibitor for Gli1 and Gli2.
Glasdegib
T6514
Glasdegib (PF-04449913) (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.
CUR61414
T15019
CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM).
Ciliobrevin A
T3156
Ciliobrevin A (HPI-4) is an inhibitor of hedgehog signaling pathway with an IC50 <10 μM.
CUR61414 hydrochloride
T15019L
CUR61414 hydrochloride is a potent and cell permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM). CUR61414 hydrochloride is a small-molecule amin...
HPI 1
T22089
HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5...
SMANT hydrochloride
T23370
SMANT hydrochloride (N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride) is an antagonist of Smoothened accumulation.
Ciliobrevin D
T14965
Ciliobrevin D is a AAA+ ATPase motor cytoplasmic dynein inhibitor. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation and it also inhibit...
Itraconazole
T1011
Itraconazole (R51211) is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.
SAG dihydrochloride
T40465
SAG dihydrochloride, a powerful agonist of the Smoothened (Smo) receptor (EC 50 = 3 nM; Kd = 59 nM), effectively activates the Hedgehog signaling pathway. It als...
Tolnaftate
T1094
Tolnaftate (NP-27) is a synthetic antifungal agent.
SAG hydrochloride (912545-86-9(free base))
T4211
SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist.
HhAntag
T3460
HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity....
Taladegib
T2666
Taladegib (LY2940680) is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antin...
GSA-10
T22814
Smoothened (Smo) receptor agonist
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TargetMol