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HSP

Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions. They were first described in relation to heat shock, but are now known to also be expressed during other stresses including exposure to cold, UV light and during wound healing or tissue remodeling. Many members of this group perform chaperone functions by stabilizing new proteins to ensure correct folding or by helping to refold proteins that were damaged by the cell stress.
Cat. No. Product name CAS No. Purity Chemical Structure
T5350 JG-98 1456551-16-8 99.35%
JG-98 is an allosteric Hsp70 inhibitor, displays high active against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50s: 0.4/0.7 μM).
T6170 Elesclomol 488832-69-5 99.46%
Elesclomol (STA-4783) is an effective oxidative stress inducer that elicits pro-apoptosis of tumor cells.
T16994 Pimitespib 1260533-36-5 99.49%
TAS-116 is an ATP-competitive and highly specific HSP90α/HSP90β inhibitor (Kis: 34.7 nM and 21.3 nM, respectively).
T7010 VER-155008 1134156-31-2 99.55%
VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold se...
T8829 2',4'-DIHYDROXYCHALCONE 1776-30-3 99.59%
2',4'-Dihydroxychalcone as a compound with Hsp90 inhibitory and antifungal effects
T21883 Gedunin 2753-30-2 99.68%
Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Gedunin is an Hsp90 inhibitor, and inhibits ovarian cancer c...
T9202 DDO-5936 2355377-13-6 99.69%
DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.
T8858 DTHIB 897326-30-6 99.69%
DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.
T1501 Rifabutin 72559-06-9 99.8%
Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and tra...
T6284 Onalespib 912999-49-6 99.82%
Onalespib is a synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Onalespib select...
T6609 NMS-E973 1253584-84-7 99.82%
NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.
T6290 Tanespimycin 75747-14-7 99.83%
Tanespimycin (17-AAG) is an inhibitor of Hsp90 that selectively inhibits BT474 tumor cell Hsp90 (IC50: 5 nM).
T6855 HA15 1609402-14-3 99.86%
HA15 targets specifically BiP/GRP78/HSPA5. HA15 exhibits anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells t...
T2908 Palmitic acid 57-10-3 99.87%
Palmitic acid is the most common saturated fatty acid found in animals, plants and microorganisms with anti-tumor activity.
T3454 VER-49009 558640-51-0 99.93%
VER-49009 is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).
T6297 Alvespimycin hydrochloride 467214-21-7 99.94%
17-DMAG is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2.
T2258 VER-50589 747413-08-7 99.95%
VER-50589 is a potent HSP90 inhibitor.
T2309 Ganetespib 888216-25-9 99.95%
Ganetespib is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.
T6305 SNX2112 908112-43-6 99.95%
SNX-2112 is an orally active Hsp90 inhibitor, with a Kd of 16 nM.
T5008 Teprenone 6809-52-5 99.96%
Teprenone is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).
JG-98
T5350
JG-98 is an allosteric Hsp70 inhibitor, displays high active against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50s: 0.4/0.7 μM).
Elesclomol
T6170
Elesclomol (STA-4783) is an effective oxidative stress inducer that elicits pro-apoptosis of tumor cells.
Pimitespib
T16994
TAS-116 is an ATP-competitive and highly specific HSP90α/HSP90β inhibitor (Kis: 34.7 nM and 21.3 nM, respectively).
VER-155008
T7010
VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold se...
2',4'-DIHYDROXYCHALCONE
T8829
2',4'-Dihydroxychalcone as a compound with Hsp90 inhibitory and antifungal effects
Gedunin
T21883
Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Gedunin is an Hsp90 inhibitor, and inhibits ovarian cancer c...
DDO-5936
T9202
DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.
DTHIB
T8858
DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.
Rifabutin
T1501
Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and tra...
Onalespib
T6284
Onalespib is a synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Onalespib select...
NMS-E973
T6609
NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.
Tanespimycin
T6290
Tanespimycin (17-AAG) is an inhibitor of Hsp90 that selectively inhibits BT474 tumor cell Hsp90 (IC50: 5 nM).
HA15
T6855
HA15 targets specifically BiP/GRP78/HSPA5. HA15 exhibits anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells t...
Palmitic acid
T2908
Palmitic acid is the most common saturated fatty acid found in animals, plants and microorganisms with anti-tumor activity.
VER-49009
T3454
VER-49009 is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).
Alvespimycin hydrochloride
T6297
17-DMAG is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2.
VER-50589
T2258
VER-50589 is a potent HSP90 inhibitor.
Ganetespib
T2309
Ganetespib is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.
SNX2112
T6305
SNX-2112 is an orally active Hsp90 inhibitor, with a Kd of 16 nM.
Teprenone
T5008
Teprenone is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).
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