HSP

Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions. They were first described in relation to heat shock, but are now known to also be expressed during other stresses including exposure to cold, UV light and during wound healing or tissue remodeling. Many members of this group perform chaperone functions by stabilizing new proteins to ensure correct folding or by helping to refold proteins that were damaged by the cell stress.

Cat. No.	Product name	CAS No.	Purity
T5350	JG-98	1456551-16-8	99.35%
T5350	JG-98 is an allosteric Hsp70 inhibitor, displays high active against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50s: 0.4/0.7 μM).
T6170	Elesclomol	488832-69-5	99.46%
T6170	Elesclomol (STA-4783) is an effective oxidative stress inducer that elicits pro-apoptosis of tumor cells.
T16994	Pimitespib	1260533-36-5	99.49%
T16994	TAS-116 is an ATP-competitive and highly specific HSP90α/HSP90β inhibitor (Kis: 34.7 nM and 21.3 nM, respectively).
T7010	VER-155008	1134156-31-2	99.55%
T7010	VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold se...
T8829	2',4'-DIHYDROXYCHALCONE	1776-30-3	99.59%
T8829	2',4'-Dihydroxychalcone as a compound with Hsp90 inhibitory and antifungal effects
T21883	Gedunin	2753-30-2	99.68%
T21883	Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Gedunin is an Hsp90 inhibitor, and inhibits ovarian cancer c...
T9202	DDO-5936	2355377-13-6	99.69%
T9202	DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.
T8858	DTHIB	897326-30-6	99.69%
T8858	DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.
T1501	Rifabutin	72559-06-9	99.8%
T1501	Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and tra...
T6284	Onalespib	912999-49-6	99.82%
T6284	Onalespib is a synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Onalespib select...
T6609	NMS-E973	1253584-84-7	99.82%
T6609	NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.
T6290	Tanespimycin	75747-14-7	99.83%
T6290	Tanespimycin (17-AAG) is an inhibitor of Hsp90 that selectively inhibits BT474 tumor cell Hsp90 (IC50: 5 nM).
T6855	HA15	1609402-14-3	99.86%
T6855	HA15 targets specifically BiP/GRP78/HSPA5. HA15 exhibits anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells t...
T2908	Palmitic acid	57-10-3	99.87%
T2908	Palmitic acid is the most common saturated fatty acid found in animals, plants and microorganisms with anti-tumor activity.
T3454	VER-49009	558640-51-0	99.93%
T3454	VER-49009 is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).
T6297	Alvespimycin hydrochloride	467214-21-7	99.94%
T6297	17-DMAG is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2.
T2258	VER-50589	747413-08-7	99.95%
T2258	VER-50589 is a potent HSP90 inhibitor.
T2309	Ganetespib	888216-25-9	99.95%
T2309	Ganetespib is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.
T6305	SNX2112	908112-43-6	99.95%
T6305	SNX-2112 is an orally active Hsp90 inhibitor, with a Kd of 16 nM.
T5008	Teprenone	6809-52-5	99.96%
T5008	Teprenone is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).