HSP

Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions. They were first described in relation to heat shock, but are now known to also be expressed during other stresses including exposure to cold, UV light and during wound healing or tissue remodeling. Many members of this group perform chaperone functions by stabilizing new proteins to ensure correct folding or by helping to refold proteins that were damaged by the cell stress.

Cat. No.	Product name	CAS No.	Purity
T4125	HSF1A	1196723-93-9	98.94%
T4125	HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis.
T7010	VER-155008	1134156-31-2	98.88%
T7010	VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold se...
T36123	3-Phenyltoxoflavin	32502-63-9	98.84%
T36123	3-Phenyltoxoflavin (Phenyltoxoflavin) is an inhibitor of HSP90 (Kd = 585 nM) with anti-cancer activity.
T21872	CCT018159	171009-07-7	98.78%
T21872	CCT018159 is a 3,4-diarylpyrazole resorcinol, an ATP-competitive HSP90ATPase inhibitor that inhibits human Hsp90β and yeast Hsp90 with IC50s of 3.2 and 6.6 μM, r...
T6558	KW-2478	819812-04-9	98.75%
T6558	KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.
T9996	NCT-58	2411429-33-7	98.75%
T9996	NCT-58 is a potent C-terminal HSP90 inhibitor. NCT-58 does not induce the heat shock response (HSR). NCT-58 elicits anti-tumor activity via the simultaneous dow...
T20510	Novobiocin	303-81-1	98.72%
T20510	Novobiocin is an orally active and potent antibiotic.Novobiocin is a DNA gyrase inhibitor and heat shock protein 90 (Hsp90) antagonist with inhibitory effects on...
T3652	KRIBB11	342639-96-7	98.64%
T3652	KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor.
T2179	Triptolide	38748-32-2	98.52%
T2179	Triptolide (PG490) belongs to the tricyclic diterpenoid group of natural products and is an inhibitor of NF-κB activation. Triptolide exhibits immunosuppressive,...
TQ0131	Rocaglamide	84573-16-0	98.46%
TQ0131	Rocaglamide (Roc-A), isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of N...
T4342	PF-04929113 Mesylate	1173111-67-5	98.38%
T4342	PF-04929113 Mesylate (SNX-5422 Mesylate), a prodrug of SNX-2112, is an orally available Hsp90 inhibitor (Kd: 41 nM) and also induces Her-2 degradation (IC50: 37 ...
T2286	BIIB021	848695-25-0	98.38%
T2286	BIIB021 (CNF2024) is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7 nM, EC50=38 nM).
T6960	PU-H71	873436-91-0	98.31%
T6960	PU-H71 is an effective selective HSP90 inhibitor with an IC50 of 51 nM.
T3515	TRC051384 HCl	1333327-56-2	98.29%
T3515	TRC051384 is an inducer of heat shock protein Hsp70, activating heat shock factor-1 and enhancing Hsp72 expression in neurons and glial cells.
T5152	MKT-077	147366-41-4	98.2%
T5152	MKT-077 (FJ-776) is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines (EC50s: 1.4-2.2 μM in vitro) through its a...
T5826	Eupalinolide A	877822-40-7	98.18%
T5826	Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.
T6248	XL888	1149705-71-4	98.1%
T6248	XL888 is an ATP-competitive inhibitor of Hsp90 ( IC50: 24 nM). Heat shock protein 90 (Hsp90) is a chaperone that maintains the functionality of client proteins i...
T3293	Apoptozole	1054543-47-3	98.02%
T3293	Apoptozole (Apoptosis Activator VII) is an inhibitor of the ATPase domain of Hsc70 and Hsp70, and can induce apoptosis.
T8901	YUM70	423145-35-1	98.01%
T8901	YUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor(with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length pro...
T6855	HA15	1609402-14-3	98%
T6855	HA15 targets specifically BiP/GRP78/HSPA5. HA15 exhibits anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells t...