T5350 |
JG-98
|
1456551-16-8
|
99.35%
|
|
JG-98 is an allosteric Hsp70 inhibitor, displays high active against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50s: 0.4/0.7 μM).
|
T6170 |
Elesclomol
|
488832-69-5
|
99.46%
|
|
Elesclomol (STA-4783) is an effective oxidative stress inducer that elicits pro-apoptosis of tumor cells.
|
T16994 |
Pimitespib
|
1260533-36-5
|
99.49%
|
|
TAS-116 is an ATP-competitive and highly specific HSP90α/HSP90β inhibitor (Kis: 34.7 nM and 21.3 nM, respectively).
|
T7010 |
VER-155008
|
1134156-31-2
|
99.55%
|
|
VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold se...
|
T8829 |
2',4'-DIHYDROXYCHALCONE
|
1776-30-3
|
99.59%
|
|
2',4'-Dihydroxychalcone as a compound with Hsp90 inhibitory and antifungal effects
|
T21883 |
Gedunin
|
2753-30-2
|
99.68%
|
|
Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Gedunin is an Hsp90 inhibitor, and inhibits ovarian cancer c...
|
T9202 |
DDO-5936
|
2355377-13-6
|
99.69%
|
|
DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.
|
T8858 |
DTHIB
|
897326-30-6
|
99.69%
|
|
DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.
|
T1501 |
Rifabutin
|
72559-06-9
|
99.8%
|
|
Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and tra...
|
T6284 |
Onalespib
|
912999-49-6
|
99.82%
|
|
Onalespib is a synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Onalespib select...
|
T6609 |
NMS-E973
|
1253584-84-7
|
99.82%
|
|
NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.
|
T6290 |
Tanespimycin
|
75747-14-7
|
99.83%
|
|
Tanespimycin (17-AAG) is an inhibitor of Hsp90 that selectively inhibits BT474 tumor cell Hsp90 (IC50: 5 nM).
|
T6855 |
HA15
|
1609402-14-3
|
99.86%
|
|
HA15 targets specifically BiP/GRP78/HSPA5. HA15 exhibits anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells t...
|
T2908 |
Palmitic acid
|
57-10-3
|
99.87%
|
|
Palmitic acid is the most common saturated fatty acid found in animals, plants and microorganisms with anti-tumor activity.
|
T3454 |
VER-49009
|
558640-51-0
|
99.93%
|
|
VER-49009 is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).
|
T6297 |
Alvespimycin hydrochloride
|
467214-21-7
|
99.94%
|
|
17-DMAG is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2.
|
T2258 |
VER-50589
|
747413-08-7
|
99.95%
|
|
VER-50589 is a potent HSP90 inhibitor.
|
T2309 |
Ganetespib
|
888216-25-9
|
99.95%
|
|
Ganetespib is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.
|
T6305 |
SNX2112
|
908112-43-6
|
99.95%
|
|
SNX-2112 is an orally active Hsp90 inhibitor, with a Kd of 16 nM.
|
T5008 |
Teprenone
|
6809-52-5
|
99.96%
|
|
Teprenone is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).
|