HIV Protease

HIV-1 protease (PR) is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins (namely, Gag and Gag-Pol[3]) at nine cleavage sites to create the mature protein components of an HIV virion, the infectious form of a virus outside of the host cell. Without effective HIV protease, HIV virions remain uninfectious.

Cat. No.	Product name	CAS No.	Purity
T7991	2-Hydroxycinnamic acid	614-60-8	99.83%
T7991	2-Hydroxycinnamic acid is a natural product isolated from Angraecum fragrans, has photooxidant activity.
T0984	5-Fluorouracil	51-21-8	99.83%
T0984	5-Fluorouracil (5-FU) is a uracil analog, an inhibitor of DNA synthesis. 5-Fluorouracil has antitumor activity and affects pyrimidine synthesis through inhibitio...
T6420	BMS-707035	729607-74-3	99.83%
T6420	BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM. Phase 2.
T5783	Rosamultin	88515-58-6	99.83%
T5783	Rosamultin has antioxidant, antiinflammatory/antinociceptive properties,and has anti-human immunodeficiency virus (HIV) activity.
T2393	Efavirenz	154598-52-4	99.83%
T2393	Efavirenz (DMP 266) is a Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor. The mechanism of action of efavirenz is as a Non-N...
T7789	DRB	53-85-0	99.82%
T7789	DRB is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II (IC50 range of 4-10 μM)
T28918	Talviraline	163451-80-7	99.82%
T28918	Talviraline (Bay 10-8979) is an RNA-induced DNA polymerase inhibitor.Talviraline is a potent inhibitor of HIV-1-induced cell killing and HIV-1 replication in a v...
T3822	Bellidifolin	2798-25-6	99.81%
T3822	Bellidifolin (Bellidifoline) has anti-oxidation, hepatoprotective, anti-inflammatory and antitumor actions, it may contribute to the protective effects associate...
T2578	Didanosine	69655-05-6	99.81%
T2578	Didanosine (ddI) is a nucleoside reverse transcriptase inhibitor analog of adenosine (IC50: 0.49 μM).
T4S1383	Escin IA	123748-68-5	99.81%
T4S1383	Escin IA (Escin IA;Aescin IA) is a triterpene saponin isolated from horse chestnut, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TN...
TN5263	1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one	569-83-5	99.79%
TN5263	1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one (Xanthohumol) , prenylchacone flavonoid, is a natural product with...
T4S0295	Apigenin 7-glucoside	578-74-5	99.79%
T4S0295	1. Apigenin 7-glucoside (Cosmosiin) is a anti-HIV agent. 2. Cosmosiin may be beneficial for diabetic complications through their enhanced adiponectin secretion, ...
T6388	Amprenavir	161814-49-9	99.79%
T6388	Amprenavir (KVX-478) is a synthetic derivative of hydroxyethylamine sulfonamide that selectively binds to and inhibits human immunodeficiency virus (HIV) proteas...
T21746	Terameprocol	24150-24-1	99.79%
T21746	Terameprocol (EM-1421) is a synthetic tetra-methylated derivative of nordihydroguaiaretic acid (NDGA) and transcriptional inhibitor with potential antiviral, ant...
T3632	Doravirine	1338225-97-0	99.79%
T3632	Doravirine (MK-1439) is a non-nucleoside reverse transcriptase inhibitor, used in the treatment of HIV/AIDS.
T0110	Zalcitabine	7481-89-2	99.78%
T0110	Zalcitabine (Dideoxycytidine)(Dideoxycytidine;ddC; 2', 3'-Dideoxycytidine) is a nucleoside analog reverse transcriptase inhibitor (NRTI); At low concentrations, ...
T2930	α-Lipoic Acid	62-46-4	99.76%
T2930	α-Lipoic Acid (Alphalipoic acid) inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hep...
T0100L	Atazanavir	198904-31-3	99.76%
T0100L	Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.
T16276	NBD-556	333353-44-9	99.76%
T16276	NBD-556 is a small molecule mimetic of CD4. NBD-556 recognizes the HIV-1 envelope protein gp120 and induces restructuring of gp120 analogous to CD4 binding.
T3695	Pepstatin	26305-03-3	99.76%
T3695	Pepstatin (Pepsin Inhibitor S 735A) is a specific aspartic proteases inhibitor produced by actinomycetes, and inhibits the aspartic proteases cathepsin D, pepsin...