HIV Protease

HIV-1 protease (PR) is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins (namely, Gag and Gag-Pol[3]) at nine cleavage sites to create the mature protein components of an HIV virion, the infectious form of a virus outside of the host cell. Without effective HIV protease, HIV virions remain uninfectious.

Cat. No.	Product name	CAS No.	Purity
T11538	Hck-IN-1	1473404-51-1	98.29%
T11538	Hck-IN-1 is a selective Nef-dependent Hck inhibitor (IC50s: 2.8 μM and >20 μM for Nef:Hck complex and Hck) with antiretroviral activity. Hck-IN-1 is a direct and...
T6029	ONX-0914	960374-59-8	98.35%
T6029	ONX-0914 is an effective and specific immunoproteasome inhibitor, which has minimal cross-reactivity for the constitutive proteasome.
T0836	Sulfadoxine	2447-57-6	98.36%
T0836	Sulfadoxine is a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with bacteriostatic and antimalarial properties.
T7282	Tenofovir alafenamide hemifumarate	1392275-56-7	98.37%
T7282	Tenofovir alafenamide fumarate (TAF) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV)
T0200	α-Lipoic Acid	1077-28-7	98.39%
T0200	Thioctic acid is an octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by c...
T20489	Benzalphthalide	575-61-1	98.41%
T20489	Benzalphthalide is a chemical compound with anti-HIV activity.
T2865	Oleanolic Acid	508-02-1	98.51%
T2865	Oleanolic acid (Caryophyllin) is a natural compound with anti-tumor activities, which are widely distributed in plants.
TL0006	Cichoric Acid	6537-80-0	98.57%
TL0006	Chicoric Acid is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues. It also a class of cannabinomimetics...
T2775	Baicalin	21967-41-9	98.63%
T2775	Baicalin is a prolyl endopeptidase inhibitor isolated from scutellaria baicalensis, with antioxidant, anti-tumor, anti-HIV properties.
T6S2391	L-Chicoric Acid	70831-56-0	98.74%
T6S2391	L-Chicoric acid has been shown to inhibit hyaluronidase and HIV-1 integrase, and to possess phagoeytosis stimulatory activity in vitro and in vivo and antiviral ...
T0028	Gamibetal	924-49-2	98.79%
T0028	4-Amino-3-Hydroxybutanoic Acid is used as a chiral reagent in the synthesis of antiepileptic and hypotensive drug GABOB and analogues. Also used in the preparati...
T5783	Rosamultin	88515-58-6	98.8%
T5783	Rosamultin has antioxidant, antiinflammatory/antinociceptive properties,and has anti-human immunodeficiency virus (HIV) activity.
T2330	Rilpivirine	500287-72-9	98.83%
T2330	Rilpivirine is a diarylpyrimidine derivative and reverse transcriptase inhibitor with antiviral activity against HIV-1 that is used in the treatment of HIV infec...
T21474	Navuridine	84472-85-5	98.9%
T21474	Navuridine is an oral active inhibitor of HIV reverse transcriptase with a relatively short half-life.
T11281L	FGI-106 tetrahydrochloride	1149348-10-6	98.98%
T11281L	FGI-106 tetrahydrochloride is active against Ebola, Rift Valley and Dengue Fever viruses with EC50s of 100 nM, 800 nM and 400-900 nM, respectively. FGI-106 tetra...
TQ0297	Cenicriviroc	497223-25-3	98.98%
TQ0297	Cenicriviroc is an orally active, dual antagonist of CCR2/CCR5. It also inhibits both HIV-1 and HIV-2, and displays potent anti-infective and anti-inflammatory a...
T6653	Salmeterol Xinafoate	94749-08-3	99%
T6653	Salmeterol Xinafoate is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstruc...
T2480	Apabetalone	1044870-39-4	99%
T2480	RVX-208, an effective BET bromodomain inhibitor, has been investigated for the treatment of diabetes, atherosclerosis, and coronary artery disease.
T1602	Valproic acid sodium salt	1069-66-5	99%
T1602	Valproate Sodium is the sodium salt form of valproic acid with anti-epileptic activity. Valproate sodium is converted into its active form, valproate ion, in blo...
T7064	Valproic Acid	99-66-1	99%
T7064	Valproic Acid is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various mol...