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HIV Protease

HIV-1 protease (PR) is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins (namely, Gag and Gag-Pol[3]) at nine cleavage sites to create the mature protein components of an HIV virion, the infectious form of a virus outside of the host cell. Without effective HIV protease, HIV virions remain uninfectious.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T21474 Navuridine 84472-85-5 98.9%
Navuridine
Navuridine (AZdU) is an oral active inhibitor of HIV reverse transcriptase with a relatively short half-life.
T40293 GPS491 2655502-29-5 98.81%
GPS491
GPS491 has antiviral activity and inhibits HIV-1, adenovirus, and coronavirus replication by altering RNA processing.
T3122 Fangchinoline 436-77-1 98.81%
Fangchinoline
Fangchinoline (Tetrandrine B) is extracted from Stephania tetrandra S. Moore.
T0984 5-Fluorouracil 51-21-8 98.77%
5-Fluorouracil
5-Fluorouracil (5-FU) is a uracil analog, an inhibitor of DNA synthesis. 5-Fluorouracil has antitumor activity and affects pyrimidine synthesis through inhibitio...
T6S2391 L-Chicoric Acid 70831-56-0 98.74%
L-Chicoric Acid
L-Chicoric Acid (trans-Caffeoyltartaric acid) has been shown to inhibit hyaluronidase and HIV-1 integrase, and to possess phagoeytosis stimulatory activity in vi...
T5429 Theaflavin 3,3'-digallate 30462-35-2 98.71%
Theaflavin 3,3'-digallate
Theaflavin 3,3'-digallate (8-Gingerol) , a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopre...
TL0006 Cichoric Acid 6537-80-0 98.57%
Cichoric Acid
Cichoric Acid (Dicaffeoyltartaric acid) is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues. It also a ...
T1125 Shikonin 517-89-5 98.54%
Shikonin
Shikonin (Anchusa acid) is an TMEM16A chloride channel inhibitor (IC50: 6.5 μM). Shikonin is also a selective PKM2 inhibitor and can also suppress activation of ...
T6029 ONX-0914 960374-59-8 98.47%
ONX-0914
ONX-0914 (PR-957) is an effective and specific immunoproteasome inhibitor, which has minimal cross-reactivity for the constitutive proteasome.
TN1622 Ermanin 20869-95-8 98.46%
Ermanin
Ermanin is a flavonoid isolated from Tanacetum microphyllum.Ermanin inhibits platelet aggregation and has anti-tuberculosis and anti-viral/bacterial properties.E...
T2330 Rilpivirine 500287-72-9 98.45%
Rilpivirine
Rilpivirine (R278474) is a diarylpyrimidine derivative and reverse transcriptase inhibitor with antiviral activity against HIV-1 that is used in the treatment of...
T20489 Benzalphthalide 575-61-1 98.41%
Benzalphthalide
Benzalphthalide (NSC-2824) is a chemical compound with anti-HIV activity.
T2865 Oleanolic Acid 508-02-1 98.4%
Oleanolic Acid
Oleanolic Acid (Caryophyllin) is a natural compound with anti-tumor activities, which are widely distributed in plants.
T63143 DENV-IN-5 2375781-06-7 98.39%
DENV-IN-5
Denv-in-5 is an effective and selective dengue virus (DENV) inhibitor with EC50 values of 1.47, 9.23, 7.08, 8.91 μM for denV-I-IV and 0.1512 μM for HIV-1IIIB.
T0200 α-Lipoic Acid 1077-28-7 98.39%
α-Lipoic Acid
α-Lipoic Acid (DL-α-Lipoic acid) an octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is bio...
T7282 Tenofovir alafenamide hemifumarate 1392275-56-7 98.37%
Tenofovir alafenamide hemifumarate
Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TF...
T0836 Sulfadoxine 2447-57-6 98.36%
Sulfadoxine
Sulfadoxine (Sulphadoxine) is a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with bacteriostatic and antimalarial propert...
T6653 Salmeterol Xinafoate 94749-08-3 98.24%
Salmeterol Xinafoate
Salmeterol Xinafoate (GR 33343X xinafoate) is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma sympto...
T3523 Fostemsavir 864953-29-7 98.22%
Fostemsavir
Fostemsavir (BMS-663068) is an HIV-1 attachment inhibitor in development for the treatment of HIV-1 infection.
T4697 ABBV-744 2138861-99-9 98.2%
ABBV-744
ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2/3/4. It is used in the research on inflammatory diseases, cancer, and AIDS.
Navuridine
T21474
Navuridine (AZdU) is an oral active inhibitor of HIV reverse transcriptase with a relatively short half-life.
GPS491
T40293
GPS491 has antiviral activity and inhibits HIV-1, adenovirus, and coronavirus replication by altering RNA processing.
Fangchinoline
T3122
Fangchinoline (Tetrandrine B) is extracted from Stephania tetrandra S. Moore.
5-Fluorouracil
T0984
5-Fluorouracil (5-FU) is a uracil analog, an inhibitor of DNA synthesis. 5-Fluorouracil has antitumor activity and affects pyrimidine synthesis through inhibitio...
L-Chicoric Acid
T6S2391
L-Chicoric Acid (trans-Caffeoyltartaric acid) has been shown to inhibit hyaluronidase and HIV-1 integrase, and to possess phagoeytosis stimulatory activity in vi...
Theaflavin 3,3'-digallate
T5429
Theaflavin 3,3'-digallate (8-Gingerol) , a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopre...
Cichoric Acid
TL0006
Cichoric Acid (Dicaffeoyltartaric acid) is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues. It also a ...
Shikonin
T1125
Shikonin (Anchusa acid) is an TMEM16A chloride channel inhibitor (IC50: 6.5 μM). Shikonin is also a selective PKM2 inhibitor and can also suppress activation of ...
ONX-0914
T6029
ONX-0914 (PR-957) is an effective and specific immunoproteasome inhibitor, which has minimal cross-reactivity for the constitutive proteasome.
Ermanin
TN1622
Ermanin is a flavonoid isolated from Tanacetum microphyllum.Ermanin inhibits platelet aggregation and has anti-tuberculosis and anti-viral/bacterial properties.E...
Rilpivirine
T2330
Rilpivirine (R278474) is a diarylpyrimidine derivative and reverse transcriptase inhibitor with antiviral activity against HIV-1 that is used in the treatment of...
Benzalphthalide
T20489
Benzalphthalide (NSC-2824) is a chemical compound with anti-HIV activity.
Oleanolic Acid
T2865
Oleanolic Acid (Caryophyllin) is a natural compound with anti-tumor activities, which are widely distributed in plants.
DENV-IN-5
T63143
Denv-in-5 is an effective and selective dengue virus (DENV) inhibitor with EC50 values of 1.47, 9.23, 7.08, 8.91 μM for denV-I-IV and 0.1512 μM for HIV-1IIIB.
α-Lipoic Acid
T0200
α-Lipoic Acid (DL-α-Lipoic acid) an octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is bio...
Tenofovir alafenamide hemifumarate
T7282
Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TF...
Sulfadoxine
T0836
Sulfadoxine (Sulphadoxine) is a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with bacteriostatic and antimalarial propert...
Salmeterol Xinafoate
T6653
Salmeterol Xinafoate (GR 33343X xinafoate) is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma sympto...
Fostemsavir
T3523
Fostemsavir (BMS-663068) is an HIV-1 attachment inhibitor in development for the treatment of HIV-1 infection.
ABBV-744
T4697
ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2/3/4. It is used in the research on inflammatory diseases, cancer, and AIDS.
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TargetMol