HIV Protease

HIV-1 protease (PR) is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins (namely, Gag and Gag-Pol[3]) at nine cleavage sites to create the mature protein components of an HIV virion, the infectious form of a virus outside of the host cell. Without effective HIV protease, HIV virions remain uninfectious.

Cat. No.	Product name	CAS No.	Purity
T6098	Cabotegravir	1051375-10-0	99.71%
T6098	Cabotegravir (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (IC50: 3.0 nM).
T1284	Megestrol acetate	595-33-5	99.72%
T1284	Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties. ...
T2332	Elvitegravir	697761-98-1	99.73%
T2332	Elvitegravir is a Human Immunodeficiency Virus Integrase Strand Transfer Inhibitor. The mechanism of action of elvitegravir is as an HIV Integrase Inhibitor, and...
T2329	Dolutegravir sodium	1051375-19-9	99.74%
T2329	Dolutegravir sodium salt(DTG; GSK1349572) is an HIV integrase inhibitor(IC50: 2.7 nM), modest activity against raltegravir-resistant signature mutants Y143R, Q14...
T3199	PTACH	848354-66-5	99.74%
T3199	PTACH (NCH-51) is a SAHA-based inhibitor of human HDAC. It can potently inhibit the growth of various human Y cells (EC50: 1 to 10 μM).
T1883	Des(benzylpyridyl) Atazanavi	1192224-24-0	99.75%
T1883	The N-dealkylated metabolite (M1) of Atazanavir, a HIV protease inhibitor.
T7212	Delavirdine mesylate	147221-93-0	99.75%
T7212	Delavirdine (mesylate) is a non-nucleoside reverse transcriptase inhibitor (NNRTI).
T16276	NBD-556	333353-44-9	99.76%
T16276	NBD-556 is a small molecule mimetic of CD4. NBD-556 recognizes the HIV-1 envelope protein gp120 and induces restructuring of gp120 analogous to CD4 binding.
T0100L	Atazanavir	198904-31-3	99.76%
T0100L	Atazanavir(BMS-232632) is an highly effective HIV-1 protease inhibitor.
T2930	α-Lipoic Acid	62-46-4	99.76%
T2930	α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells.α-Lipoi...
T1815	Dapivirine	244767-67-7	99.77%
T1815	Dapivirine is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor.
T2239L	Raltegravir	518048-05-0	99.77%
T2239L	Raltegravir is a pyrrolidinone derivative and HIV INTEGRASE INHIBITOR that is used in combination with other ANTI-HIV AGENTS for the treatment of HIV INFECTION.
T0110	Zalcitabine	7481-89-2	99.78%
T0110	Zalcitabine(Dideoxycytidine;ddC; 2', 3'-Dideoxycytidine) is a nucleoside analog reverse transcriptase inhibitor (NRTI); At low concentrations, It can potently in...
T6388	Amprenavir	161814-49-9	99.79%
T6388	Amprenavir is a synthetic derivative of hydroxyethylamine sulfonamide that selectively binds to and inhibits human immunodeficiency virus (HIV) protease.
T4S0295	Apigenin 7-glucoside	578-74-5	99.79%
T4S0295	1. Cosmosiin is a anti-HIV agent. 2. Cosmosiin may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylatio...
T3632	Doravirine	1338225-97-0	99.79%
T3632	Doravirine is a non-nucleoside reverse transcriptase inhibitor, used in the treatment of HIV/AIDS.
T3772	Maslinic acid	4373-41-5	99.8%
T3772	Maslinic acid is a DNA polymerase B inhibitor.
T3822	Bellidifolin	2798-25-6	99.81%
T3822	Bellidifolin has anti-oxidation, hepatoprotective, anti-inflammatory and antitumor actions, it may contribute to the protective effects associated with nerve inj...
T2578	Didanosine	69655-05-6	99.81%
T2578	Didanosine is a nucleoside reverse transcriptase inhibitor analog of adenosine (IC50: 0.49 μM).
T4S1383	Escin IA	123748-68-5	99.81%
T4S1383	Escin IA is a triterpene saponin isolated from horse chestnut, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activit...