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HIV Protease

HIV-1 protease (PR) is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins (namely, Gag and Gag-Pol[3]) at nine cleavage sites to create the mature protein components of an HIV virion, the infectious form of a virus outside of the host cell. Without effective HIV protease, HIV virions remain uninfectious.
Cat. No. Product name CAS No. Purity Chemical Structure
T6098 Cabotegravir 1051375-10-0 99.71%
Cabotegravir (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (IC50: 3.0 nM).
T1284 Megestrol acetate 595-33-5 99.72%
Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties. ...
T2332 Elvitegravir 697761-98-1 99.73%
Elvitegravir is a Human Immunodeficiency Virus Integrase Strand Transfer Inhibitor. The mechanism of action of elvitegravir is as an HIV Integrase Inhibitor, and...
T2329 Dolutegravir sodium 1051375-19-9 99.74%
Dolutegravir sodium salt(DTG; GSK1349572) is an HIV integrase inhibitor(IC50: 2.7 nM), modest activity against raltegravir-resistant signature mutants Y143R, Q14...
T3199 PTACH 848354-66-5 99.74%
PTACH (NCH-51) is a SAHA-based inhibitor of human HDAC. It can potently inhibit the growth of various human Y cells (EC50: 1 to 10 μM).
T1883 Des(benzylpyridyl) Atazanavi 1192224-24-0 99.75%
The N-dealkylated metabolite (M1) of Atazanavir, a HIV protease inhibitor.
T7212 Delavirdine mesylate 147221-93-0 99.75%
Delavirdine (mesylate) is a non-nucleoside reverse transcriptase inhibitor (NNRTI).
T16276 NBD-556 333353-44-9 99.76%
NBD-556 is a small molecule mimetic of CD4. NBD-556 recognizes the HIV-1 envelope protein gp120 and induces restructuring of gp120 analogous to CD4 binding.
T0100L Atazanavir 198904-31-3 99.76%
Atazanavir(BMS-232632) is an highly effective HIV-1 protease inhibitor.
T2930 α-Lipoic Acid 62-46-4 99.76%
α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells.α-Lipoi...
T1815 Dapivirine 244767-67-7 99.77%
Dapivirine is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor.
T2239L Raltegravir 518048-05-0 99.77%
Raltegravir is a pyrrolidinone derivative and HIV INTEGRASE INHIBITOR that is used in combination with other ANTI-HIV AGENTS for the treatment of HIV INFECTION.
T0110 Zalcitabine 7481-89-2 99.78%
Zalcitabine(Dideoxycytidine;ddC; 2', 3'-Dideoxycytidine) is a nucleoside analog reverse transcriptase inhibitor (NRTI); At low concentrations, It can potently in...
T6388 Amprenavir 161814-49-9 99.79%
Amprenavir is a synthetic derivative of hydroxyethylamine sulfonamide that selectively binds to and inhibits human immunodeficiency virus (HIV) protease.
T4S0295 Apigenin 7-glucoside 578-74-5 99.79%
1. Cosmosiin is a anti-HIV agent. 2. Cosmosiin may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylatio...
T3632 Doravirine 1338225-97-0 99.79%
Doravirine is a non-nucleoside reverse transcriptase inhibitor, used in the treatment of HIV/AIDS.
T3772 Maslinic acid 4373-41-5 99.8%
Maslinic acid is a DNA polymerase B inhibitor.
T3822 Bellidifolin 2798-25-6 99.81%
Bellidifolin has anti-oxidation, hepatoprotective, anti-inflammatory and antitumor actions, it may contribute to the protective effects associated with nerve inj...
T2578 Didanosine 69655-05-6 99.81%
Didanosine is a nucleoside reverse transcriptase inhibitor analog of adenosine (IC50: 0.49 μM).
T4S1383 Escin IA 123748-68-5 99.81%
Escin IA is a triterpene saponin isolated from horse chestnut, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activit...
Cabotegravir
T6098
Cabotegravir (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (IC50: 3.0 nM).
Megestrol acetate
T1284
Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties. ...
Elvitegravir
T2332
Elvitegravir is a Human Immunodeficiency Virus Integrase Strand Transfer Inhibitor. The mechanism of action of elvitegravir is as an HIV Integrase Inhibitor, and...
Dolutegravir sodium
T2329
Dolutegravir sodium salt(DTG; GSK1349572) is an HIV integrase inhibitor(IC50: 2.7 nM), modest activity against raltegravir-resistant signature mutants Y143R, Q14...
PTACH
T3199
PTACH (NCH-51) is a SAHA-based inhibitor of human HDAC. It can potently inhibit the growth of various human Y cells (EC50: 1 to 10 μM).
Des(benzylpyridyl) Atazanavi
T1883
The N-dealkylated metabolite (M1) of Atazanavir, a HIV protease inhibitor.
Delavirdine mesylate
T7212
Delavirdine (mesylate) is a non-nucleoside reverse transcriptase inhibitor (NNRTI).
NBD-556
T16276
NBD-556 is a small molecule mimetic of CD4. NBD-556 recognizes the HIV-1 envelope protein gp120 and induces restructuring of gp120 analogous to CD4 binding.
Atazanavir
T0100L
Atazanavir(BMS-232632) is an highly effective HIV-1 protease inhibitor.
α-Lipoic Acid
T2930
α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells.α-Lipoi...
Dapivirine
T1815
Dapivirine is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor.
Raltegravir
T2239L
Raltegravir is a pyrrolidinone derivative and HIV INTEGRASE INHIBITOR that is used in combination with other ANTI-HIV AGENTS for the treatment of HIV INFECTION.
Zalcitabine
T0110
Zalcitabine(Dideoxycytidine;ddC; 2', 3'-Dideoxycytidine) is a nucleoside analog reverse transcriptase inhibitor (NRTI); At low concentrations, It can potently in...
Amprenavir
T6388
Amprenavir is a synthetic derivative of hydroxyethylamine sulfonamide that selectively binds to and inhibits human immunodeficiency virus (HIV) protease.
Apigenin 7-glucoside
T4S0295
1. Cosmosiin is a anti-HIV agent. 2. Cosmosiin may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylatio...
Doravirine
T3632
Doravirine is a non-nucleoside reverse transcriptase inhibitor, used in the treatment of HIV/AIDS.
Maslinic acid
T3772
Maslinic acid is a DNA polymerase B inhibitor.
Bellidifolin
T3822
Bellidifolin has anti-oxidation, hepatoprotective, anti-inflammatory and antitumor actions, it may contribute to the protective effects associated with nerve inj...
Didanosine
T2578
Didanosine is a nucleoside reverse transcriptase inhibitor analog of adenosine (IC50: 0.49 μM).
Escin IA
T4S1383
Escin IA is a triterpene saponin isolated from horse chestnut, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activit...
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