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HCV Protease

NS2-3 protease (of hepatitis C virus, HCV) is an enzyme responsible for proteolytic cleavage between NS2 and NS3, which are non-structural proteins that form part of the HCV virus particle. NS3 protease of hepatitis C virus, on the other hand, is responsible for the cleavage of non-structural protein downstream. Both of these proteases are directly involved in HCV genome replication, that is, during the viral life-cycle that leads to virus multiplication in the host that has been infected by the virus.
Cat. No. Product name CAS No. Purity Chemical Structure
T5126 Glecaprevir 1365970-03-1 99.16%
Glecaprevir is an HCV NS3/4A protease inhibitor, (IC50s: 3.5-11.3 nM).
T4988 Boceprevir 394730-60-0 99.16%
Boceprevir is a novel, potent, highly selective, orally bioavailable HCV NS3 protease inhibitor with Ki of 14 nM in both enzyme assay and EC90 of 350 nM in cell-...
TQ0122L VCH-916 free acid(1200133-34-1 free base) 914778-92-0 99.19%
VCH-916 is a novel nonnucleoside HCV NS5B polymerase inhibitor.
T2117 PSI-6206 863329-66-2 99.33%
PSI-6206 (RO2433) is a selective HCV RNA polymerase inhibitor.
T7607 PSI-6130 817204-33-4 99.36%
PSI-6130 is a potent and selective HCV NS5B polymerase inhibitor. PSI-6130 inhibits HCV replication with a mean IC50 of 0.6 μM.
T16088 MK-0608 443642-29-3 99.42%
MK-0608 is an orally bioavailable HCV replication inhibitor in vitro(EC50 = 0.3 μM and EC90=1.3 μM in the subgenomic-replicon assay).
T21537L TMC647055 Choline Hydroxide Salt T21537L 99.44%
TMC647055 Choline Hydroxide Salt is a novel and potent non-nucleoside inhibitor of the HCV NS5B polymerase which potentially for the treatment of HCV infection. ...
T7158 Ombitasvir 1258226-87-7 99.56%
Ombitasvir is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) non-structural protein 5A (NS5A).with EC50s of 0.82 to 19.3 pM against H...
T3226 Paritaprevir 1221573-85-8 99.57%
Paritaprevir is an orally bioavailable, synthetic acylsulfonamide inhibitor of the hepatitis C virus (HCV) protease complex comprised of non-structural protein 3...
T3810 Saikosaponin B2 58316-41-9 99.59%
Saikosaponin B2 acts on HCV E2 and inhibits infection by several genotypic strains and prevents binding of serum-derived HCV onto hepatoma cells. Saikosaponin B2...
T3489 Dasabuvir 1132935-63-7 99.62%
Dasabuvir is a non-nucleoside inhibitor of the hepatitis C virus (HCV) non-structural protein 5B (NS5B), an RNA-dependent RNA polymerase, with potential activity...
T3821 Deapioplatycodin D 78763-58-3 99.64%
Deapi-platycodin and platycodin D can regulate the production and secretion of airway mucin and, at least in part, explains the traditional use of aqueous extrac...
T2770 Gentiopicroside 20831-76-9 99.64%
Gentiopicroside, a naturally occurring iridoid glycoside, extracted from Gentiana manshurica Kitag, inhibits P450 activity, with an IC50 and a Ki of 61 μM and 22...
T3001 Honokiol 35354-74-6 99.65%
Honokiol is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2.
T3444 Merimepodib 198821-22-6 99.66%
Merimepodib is a novel noncompetitive inhibitor of Inosine monophosphate dehydrogenase(IMPDH).
T15282 Filibuvir 877130-28-4 99.68%
Filibuvir is a selective and noncovalent inhibitor of HCV NS5B RNA-dependent RNA polymerase. Filibuvir inhibits genotype 1a and 1b replicons with EC50s of 59 nM....
T9341 Bemnifosbuvir 1998705-64-8 99.69%
Bemnifosbuvir is a novel phosphoramidate prodrug of 2'-fluoro-2'-C-methylguanosine-5'-monophosphate that has potent in vitro activity against HCV.
T2047 AG-1478 153436-53-4 99.71%
AG-1478 (Tyrphostin AG-1478) is a selective EGFR inhibitor.
T5127 ABT530 1353900-92-1 99.73%
ABT-530 (Pibrentasvir) is an HCV NS5A inhibitor with EC50s ranging from 1.4-5.0 pM against HCV replicons containing NS5A from genotypes 1-6.
T9331 Bemnifosbuvir hemisulfate 2241337-84-6 99.74%
Bemnifosbuvir hemisulfate is a potent inhibitor of HCV virus replication.
Glecaprevir
T5126
Glecaprevir is an HCV NS3/4A protease inhibitor, (IC50s: 3.5-11.3 nM).
Boceprevir
T4988
Boceprevir is a novel, potent, highly selective, orally bioavailable HCV NS3 protease inhibitor with Ki of 14 nM in both enzyme assay and EC90 of 350 nM in cell-...
VCH-916 free acid(1200133-34-1 free base)
TQ0122L
VCH-916 is a novel nonnucleoside HCV NS5B polymerase inhibitor.
PSI-6206
T2117
PSI-6206 (RO2433) is a selective HCV RNA polymerase inhibitor.
PSI-6130
T7607
PSI-6130 is a potent and selective HCV NS5B polymerase inhibitor. PSI-6130 inhibits HCV replication with a mean IC50 of 0.6 μM.
MK-0608
T16088
MK-0608 is an orally bioavailable HCV replication inhibitor in vitro(EC50 = 0.3 μM and EC90=1.3 μM in the subgenomic-replicon assay).
TMC647055 Choline Hydroxide Salt
T21537L
TMC647055 Choline Hydroxide Salt is a novel and potent non-nucleoside inhibitor of the HCV NS5B polymerase which potentially for the treatment of HCV infection. ...
Ombitasvir
T7158
Ombitasvir is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) non-structural protein 5A (NS5A).with EC50s of 0.82 to 19.3 pM against H...
Paritaprevir
T3226
Paritaprevir is an orally bioavailable, synthetic acylsulfonamide inhibitor of the hepatitis C virus (HCV) protease complex comprised of non-structural protein 3...
Saikosaponin B2
T3810
Saikosaponin B2 acts on HCV E2 and inhibits infection by several genotypic strains and prevents binding of serum-derived HCV onto hepatoma cells. Saikosaponin B2...
Dasabuvir
T3489
Dasabuvir is a non-nucleoside inhibitor of the hepatitis C virus (HCV) non-structural protein 5B (NS5B), an RNA-dependent RNA polymerase, with potential activity...
Deapioplatycodin D
T3821
Deapi-platycodin and platycodin D can regulate the production and secretion of airway mucin and, at least in part, explains the traditional use of aqueous extrac...
Gentiopicroside
T2770
Gentiopicroside, a naturally occurring iridoid glycoside, extracted from Gentiana manshurica Kitag, inhibits P450 activity, with an IC50 and a Ki of 61 μM and 22...
Honokiol
T3001
Honokiol is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2.
Merimepodib
T3444
Merimepodib is a novel noncompetitive inhibitor of Inosine monophosphate dehydrogenase(IMPDH).
Filibuvir
T15282
Filibuvir is a selective and noncovalent inhibitor of HCV NS5B RNA-dependent RNA polymerase. Filibuvir inhibits genotype 1a and 1b replicons with EC50s of 59 nM....
Bemnifosbuvir
T9341
Bemnifosbuvir is a novel phosphoramidate prodrug of 2'-fluoro-2'-C-methylguanosine-5'-monophosphate that has potent in vitro activity against HCV.
AG-1478
T2047
AG-1478 (Tyrphostin AG-1478) is a selective EGFR inhibitor.
ABT530
T5127
ABT-530 (Pibrentasvir) is an HCV NS5A inhibitor with EC50s ranging from 1.4-5.0 pM against HCV replicons containing NS5A from genotypes 1-6.
Bemnifosbuvir hemisulfate
T9331
Bemnifosbuvir hemisulfate is a potent inhibitor of HCV virus replication.
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