HCV Protease

NS2-3 protease (of hepatitis C virus, HCV) is an enzyme responsible for proteolytic cleavage between NS2 and NS3, which are non-structural proteins that form part of the HCV virus particle. NS3 protease of hepatitis C virus, on the other hand, is responsible for the cleavage of non-structural protein downstream. Both of these proteases are directly involved in HCV genome replication, that is, during the viral life-cycle that leads to virus multiplication in the host that has been infected by the virus.

Cat. No.	Product name	CAS No.	Purity
T5126	Glecaprevir	1365970-03-1	99.16%
T5126	Glecaprevir is an HCV NS3/4A protease inhibitor, (IC50s: 3.5-11.3 nM).
T4988	Boceprevir	394730-60-0	99.16%
T4988	Boceprevir is a novel, potent, highly selective, orally bioavailable HCV NS3 protease inhibitor with Ki of 14 nM in both enzyme assay and EC90 of 350 nM in cell-...
TQ0122L	VCH-916 free acid(1200133-34-1 free base)	914778-92-0	99.19%
TQ0122L	VCH-916 is a novel nonnucleoside HCV NS5B polymerase inhibitor.
T2117	PSI-6206	863329-66-2	99.33%
T2117	PSI-6206 (RO2433) is a selective HCV RNA polymerase inhibitor.
T7607	PSI-6130	817204-33-4	99.36%
T7607	PSI-6130 is a potent and selective HCV NS5B polymerase inhibitor. PSI-6130 inhibits HCV replication with a mean IC50 of 0.6 μM.
T16088	MK-0608	443642-29-3	99.42%
T16088	MK-0608 is an orally bioavailable HCV replication inhibitor in vitro(EC50 = 0.3 μM and EC90=1.3 μM in the subgenomic-replicon assay).
T21537L	TMC647055 Choline Hydroxide Salt	T21537L	99.44%
T21537L	TMC647055 Choline Hydroxide Salt is a novel and potent non-nucleoside inhibitor of the HCV NS5B polymerase which potentially for the treatment of HCV infection. ...
T7158	Ombitasvir	1258226-87-7	99.56%
T7158	Ombitasvir is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) non-structural protein 5A (NS5A).with EC50s of 0.82 to 19.3 pM against H...
T3226	Paritaprevir	1221573-85-8	99.57%
T3226	Paritaprevir is an orally bioavailable, synthetic acylsulfonamide inhibitor of the hepatitis C virus (HCV) protease complex comprised of non-structural protein 3...
T3810	Saikosaponin B2	58316-41-9	99.59%
T3810	Saikosaponin B2 acts on HCV E2 and inhibits infection by several genotypic strains and prevents binding of serum-derived HCV onto hepatoma cells. Saikosaponin B2...
T3489	Dasabuvir	1132935-63-7	99.62%
T3489	Dasabuvir is a non-nucleoside inhibitor of the hepatitis C virus (HCV) non-structural protein 5B (NS5B), an RNA-dependent RNA polymerase, with potential activity...
T3821	Deapioplatycodin D	78763-58-3	99.64%
T3821	Deapi-platycodin and platycodin D can regulate the production and secretion of airway mucin and, at least in part, explains the traditional use of aqueous extrac...
T2770	Gentiopicroside	20831-76-9	99.64%
T2770	Gentiopicroside, a naturally occurring iridoid glycoside, extracted from Gentiana manshurica Kitag, inhibits P450 activity, with an IC50 and a Ki of 61 μM and 22...
T3001	Honokiol	35354-74-6	99.65%
T3001	Honokiol is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2.
T3444	Merimepodib	198821-22-6	99.66%
T3444	Merimepodib is a novel noncompetitive inhibitor of Inosine monophosphate dehydrogenase(IMPDH).
T15282	Filibuvir	877130-28-4	99.68%
T15282	Filibuvir is a selective and noncovalent inhibitor of HCV NS5B RNA-dependent RNA polymerase. Filibuvir inhibits genotype 1a and 1b replicons with EC50s of 59 nM....
T9341	Bemnifosbuvir	1998705-64-8	99.69%
T9341	Bemnifosbuvir is a novel phosphoramidate prodrug of 2'-fluoro-2'-C-methylguanosine-5'-monophosphate that has potent in vitro activity against HCV.
T2047	AG-1478	153436-53-4	99.71%
T2047	AG-1478 (Tyrphostin AG-1478) is a selective EGFR inhibitor.
T5127	ABT530	1353900-92-1	99.73%
T5127	ABT-530 (Pibrentasvir) is an HCV NS5A inhibitor with EC50s ranging from 1.4-5.0 pM against HCV replicons containing NS5A from genotypes 1-6.
T9331	Bemnifosbuvir hemisulfate	2241337-84-6	99.74%
T9331	Bemnifosbuvir hemisulfate is a potent inhibitor of HCV virus replication.