T3483 |
FTIDC
|
873551-53-2
|
94.58%
|
|
FTIDC is a highly potent and selective allosteric antagonist of mGluR1 receptors and shows very weak potency against human and rat mGluR5 receptors. The inhibiti...
|
T22730 |
DL-AP3
|
20263-06-3
|
95%
|
|
DL-AP3 is a competitive group I metabotropic glutamate receptor antagonist and inhibitor of phosphoserine phosphatase.
|
T21747 |
VU0483605
|
1623101-11-0
|
97.03%
|
|
VU0483605 is an effective and selective positive allosteric modulator of mGluR1 with EC50s of 390 and 356 nM for human and rat, respectively.
|
TP1943L1 |
Pep2-EVKI acetate(1315378-67-6 free base)
|
TP1943L1
|
97.63%
|
|
Pep2-EVKI acetate is a cell-permeable peptide. Pep2-EVKI acetate interferes the interaction between protein interacting with C-kinase (PICK1) and GluR2 AMPA rece...
|
T4113 |
NBQX
|
118876-58-7
|
97.66%
|
|
Potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo.
|
T21935L |
AMN082 free base
|
83027-13-8
|
97.76%
|
|
AMN082 is a metabotropic glutamate receptor 7 allosteric agonist.
|
T3010 |
Xanthurenic Acid
|
59-00-7
|
97.96%
|
|
Xanthurenic acid, a molecule arising from tryptophan metabolism by transamination of 3-hydroxykynurenine, activates mGlu2/3 Metabotropic glutamate receptors (mGl...
|
T3539 |
Lu AF21934
|
1445605-23-1
|
97.96%
|
|
Lu AF21934 is a brain-penetrant and selective mGlu4 receptor positive allosteric modulator (IC50: 500 nM, human).
|
T5884 |
Chelidamic acid
|
138-60-3
|
98%
|
|
Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid is inhibitors of glutamate decarboxylase, with a Ki of 33 μM.
|
T7292 |
FITM
|
932737-65-0
|
98%
|
|
FITM is a potent negative allosteric modulator of mGlu1 receptor(Ki : 2.5 nM).
|
T7304 |
DNQX
|
2379-57-9
|
98%
|
|
DNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors, respectively)
|
T0675 |
Topiramate
|
97240-79-4
|
98%
|
|
Topiramate is a unique antiseizure medication that is used in the treatment of partial and generalized seizures. Topiramate has been rarely associated with hepat...
|
T7515 |
MTEP hydrochloride
|
1186195-60-7
|
98%
|
|
MTEP hydrochloride is non-competitive mGlu5 antagonist (IC50 and Ki of 5 nM and 16 nM, respectively)
|
T0256 |
Citric acid trilithium salt tetrahydrate
|
6080-58-6
|
98%
|
|
Lithium Citrate, the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways and me...
|
T7579 |
1-BCP
|
34023-62-6
|
98%
|
|
1-BCP is a centrally active drug that modulates AMPA receptor gated currents.
|
T7178 |
CNQX
|
115066-14-3
|
98%
|
|
CNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively)
|
T3486 |
3-MATIDA
|
518357-51-2
|
98.41%
|
|
3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a). Displays ≥ 40-fold selectivity over other receptors: mGluR-5, mGluR-2, mGluR-4 (mGluR-4...
|
T8434 |
SIB-1757
|
31993-01-8
|
98.49%
|
|
SIB-1757 is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM)
|
T9021 |
Ro0711401
|
714971-87-6
|
98.54%
|
|
Ro0711401 is an agonist of mGlu1 receptor.
|
T16524 |
Philanthotoxin 74 dihydrochloride
|
1227301-51-0
|
98.6%
|
|
Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1.
|