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GABA Receptor

The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory compound in the mature vertebrate central nervous system. There are two classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors); whereas GABAB receptors are G protein-coupled receptors, also called metabotropic receptors.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T0128L Vigabatrin Hydrochloride 1391054-02-6
Vigabatrin Hydrochloride
Vigabatrin Hydrochloride (γ-Vinyl-GABA hydrochloride) is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA), which irreversibly in...
T16717 Radequinil 219846-31-8 98%
Radequinil
Radequinil is a benzodiazepine receptor partial inverse agonist. Rade quinil binds to GABA(-) and GABA(+) ligand (Kis: 5.15 and 6.11 nM, respectively).
TN3351 Aflatrem 70553-75-2 98%
Aflatrem
Aflatrem is a tremorgenic mycotoxin with acute neurotoxic effects, a single low dose of aflatrem is able to induce degeneration of neuronal processes in hippocam...
T14938 CGP 36742 123690-78-8 98%
CGP 36742
CGP 36742 is a selective antagonist of the GABAB receptor that can penetrate the blood-brain barrier after peripheral administration (IC50: 32 μM). It is useful ...
T16794 RO 4938581 883093-10-5 98%
RO 4938581
RO 4938581 is an effective and selective agonist of GABAA α5 inverse (Ki: 4.6 nM for GABAA α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (Ki, ...
T78071 3-Methylglutaconic acid 5746-90-7 98%
3-Methylglutaconic acid
3-Methylglutaconic acid, a primary metabolite accumulating in 3-Methylglutaconic aciduria (MGTA), induces lipid and protein oxidation, while diminishing non-enzy...
T78111 NCS-382 sodium 131733-92-1 98%
NCS-382 sodium
NCS-382 (sodium) is a potent antagonist of the GABA receptor, exhibiting anti-sedative and anti-hypnotic properties, with applications in neurological disease re...
T78560 U-89843A 157013-85-9 98%
U-89843A
U-89843A is an allosteric modulator of the GABA_A receptor, known to enhance GABA-induced Cl^- currents [1].
T78670 Xilmenolone 2368807-26-3 98%
Xilmenolone
Xilmenolone acts as a positive allosteric modulator of the GABA_A receptor [1].
T79399 E2730 1520073-91-9 98%
E2730
E2730 is a selective and noncompetitive inhibitor of the gamma-aminobutyric acid (GABA) transporter 1 (GAT1) that exhibits oral availability as well as antiepile...
T80013 Arecaidine hydrobromide 6013-57-6 98%
Arecaidine hydrobromide
Arecaidine hydrobromide, a pyridine alkaloid, functions as a potent GABA uptake inhibitor and acts as a substrate for the H+-coupled amino acid transporter 1 (PA...
T80014 Guvacine hydrobromide 6027-92-5 98%
Guvacine hydrobromide
Guvacine hydrobromide, an alkaloid derived from the Areca catechu nut, serves as a potent inhibitor of GABA (GABA uptakp) uptake. It effectively inhibits rat GAB...
T80218 GAD65(247-266) epitope TFA 98%
GAD65(247-266) epitope TFA
GAD65(247-266) epitope TFA, a T cell epitope derived from islet antigens, exhibits competitive binding to the type I diabetes-associated molecule I-A g7, albeit ...
T80487 MmTx2 toxin 98%
MmTx2 toxin
MmTx2 toxin, extracted from the venom of the coral snake, serves as a modulator of the GABA A receptor, increasing its responsiveness to agonists. This property ...
T80489 MmTx1 toxin 98%
MmTx1 toxin
Micrurotoxin 1 (MmTx1 toxin) acts as an allosteric modulator of GABA A receptors, enhancing the receptor's sensitivity to its agonist [1].
T82357 GABA receptor Antagonist 1 98%
GABA receptor Antagonist 1
GABA receptor Antagonist 1 (compound 7w) effectively inhibits the Px RDL1 GABAR at an IC50 of 7.08 nmol/L and demonstrates insecticidal efficacy against P. xylos...
TN5147 Tilifodiolide 126724-95-6 98%
Tilifodiolide
Tilifodiolide exerts in vitro and in vivo anti-inflammatory activity and in vivo antinociceptive effects. Tilifodiolide exerted antidiarrheal activity by decreas...
T12043 (-)-Bicuculline methobromide 73604-30-5 98%
(-)-Bicuculline methobromide
(-)-Bicuculline methobromide is a potent antagonist of GABAA receptor .
T11686 Isotanshinone I 20958-17-2 98%
Isotanshinone I
Isotanshinone I with IC50s of 1.13 μM and 0.432 μM for α-glucosidase and AGE, respectively. Isotanshinone I has inhibitory activity against α-glucosidase and for...
TN1717 Guvacine 498-96-4 98%
Guvacine
Guvacine can enhance the inhibition of spinal neurones by GABA.
Vigabatrin Hydrochloride
T0128L
Vigabatrin Hydrochloride (γ-Vinyl-GABA hydrochloride) is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA), which irreversibly in...
Radequinil
T16717
Radequinil is a benzodiazepine receptor partial inverse agonist. Rade quinil binds to GABA(-) and GABA(+) ligand (Kis: 5.15 and 6.11 nM, respectively).
Aflatrem
TN3351
Aflatrem is a tremorgenic mycotoxin with acute neurotoxic effects, a single low dose of aflatrem is able to induce degeneration of neuronal processes in hippocam...
CGP 36742
T14938
CGP 36742 is a selective antagonist of the GABAB receptor that can penetrate the blood-brain barrier after peripheral administration (IC50: 32 μM). It is useful ...
RO 4938581
T16794
RO 4938581 is an effective and selective agonist of GABAA α5 inverse (Ki: 4.6 nM for GABAA α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (Ki, ...
3-Methylglutaconic acid
T78071
3-Methylglutaconic acid, a primary metabolite accumulating in 3-Methylglutaconic aciduria (MGTA), induces lipid and protein oxidation, while diminishing non-enzy...
NCS-382 sodium
T78111
NCS-382 (sodium) is a potent antagonist of the GABA receptor, exhibiting anti-sedative and anti-hypnotic properties, with applications in neurological disease re...
U-89843A
T78560
U-89843A is an allosteric modulator of the GABA_A receptor, known to enhance GABA-induced Cl^- currents [1].
Xilmenolone
T78670
Xilmenolone acts as a positive allosteric modulator of the GABA_A receptor [1].
E2730
T79399
E2730 is a selective and noncompetitive inhibitor of the gamma-aminobutyric acid (GABA) transporter 1 (GAT1) that exhibits oral availability as well as antiepile...
Arecaidine hydrobromide
T80013
Arecaidine hydrobromide, a pyridine alkaloid, functions as a potent GABA uptake inhibitor and acts as a substrate for the H+-coupled amino acid transporter 1 (PA...
Guvacine hydrobromide
T80014
Guvacine hydrobromide, an alkaloid derived from the Areca catechu nut, serves as a potent inhibitor of GABA (GABA uptakp) uptake. It effectively inhibits rat GAB...
GAD65(247-266) epitope TFA
T80218
GAD65(247-266) epitope TFA, a T cell epitope derived from islet antigens, exhibits competitive binding to the type I diabetes-associated molecule I-A g7, albeit ...
MmTx2 toxin
T80487
MmTx2 toxin, extracted from the venom of the coral snake, serves as a modulator of the GABA A receptor, increasing its responsiveness to agonists. This property ...
MmTx1 toxin
T80489
Micrurotoxin 1 (MmTx1 toxin) acts as an allosteric modulator of GABA A receptors, enhancing the receptor's sensitivity to its agonist [1].
GABA receptor Antagonist 1
T82357
GABA receptor Antagonist 1 (compound 7w) effectively inhibits the Px RDL1 GABAR at an IC50 of 7.08 nmol/L and demonstrates insecticidal efficacy against P. xylos...
Tilifodiolide
TN5147
Tilifodiolide exerts in vitro and in vivo anti-inflammatory activity and in vivo antinociceptive effects. Tilifodiolide exerted antidiarrheal activity by decreas...
(-)-Bicuculline methobromide
T12043
(-)-Bicuculline methobromide is a potent antagonist of GABAA receptor .
Isotanshinone I
T11686
Isotanshinone I with IC50s of 1.13 μM and 0.432 μM for α-glucosidase and AGE, respectively. Isotanshinone I has inhibitory activity against α-glucosidase and for...
Guvacine
TN1717
Guvacine can enhance the inhibition of spinal neurones by GABA.
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TargetMol