Ferroptosis

Ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides, and is genetically and biochemically distinct from other forms of regulated cell death such as apoptosis.

Cat. No.	Product name	CAS No.	Purity
T2A2497	L-Glutamic acid	56-86-0	99.7%
T2A2497	L-Glutamic acid (Glutaminol) acts as an excitatory transmitter, shows a direct activating effect on the release of DA from dopaminergic terminals.
T0787	Butylhydroxyanisole	25013-16-5	99.7%
T0787	Butylhydroxyanisole (BHA) is an antioxidant consisting of a mixture of two isomeric organic compounds, 2-tert-butyl-4-hydroxyanisole and 3-tert-butyl-4-hydroxyan...
T60202	MMRi62	352693-80-2	99.7%
T60202	MMRi62 (7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol), a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53)...
T77762	ROS-generating agent 1	2369030-41-9	99.67%
T77762	Ros-generating agent 1 has anticancer activity and generates ROS by covalently modifying Sec-498 residues of TrxR. ROS-generating agent 1 reduces intracellular T...
T6099	Setanaxib	1218942-37-0	99.66%
T6099	Setanaxib (GKT137831) is a potent, specific dual NADPH oxidase (NOX1/4) inhibitor.
T0214L	Pioglitazone hydrochloride	112529-15-4	99.66%
T0214L	Pioglitazone hydrochloride (AD 4833) is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic ac...
T2488	BAY 87-2243	1227158-85-1	99.65%
T2488	BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).
T3637	Pifithrin-β hydrobromide	511296-88-1	99.62%
T3637	Pifithrin-β hydrobromide (Cyclic PFT-α) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuron...
T0093L	Sorafenib	284461-73-0	99.61%
T0093L	Sorafenib (Bay 43-9006) is a multikinase inhibitor that inhibits Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, FLT3, c-Kit, and others (IC50=6/22/90/15/20/20/57/...
T1564	Cisplatin	15663-27-1	99.6%
T1564	Cisplatin (CDDP) is a DNA cross-linking agent. Cisplatin has antitumor activity and inhibits DNA synthesis by forming DNA adducts in cancer cells. Cisplatin also...
T1765	Erastin	571203-78-6	99.6%
T1765	Erastin is an iron death activator that acts on the mitochondrial VDAC in a ROS- and iron-dependent manner. Erastin has anti-tumor activity and acts selectively ...
T5515	Hemin	16009-13-5	99.59%
T5515	Hemin (Hemin chloride) is a chlorinated iron-containing porphyrin, a heme oxygenase (HO)-1 inducer. Hemin has therapeutic activity in porphyrias by reducing heme...
T1207	Lovastatin	75330-75-5	99.59%
T1207	Lovastatin (MK-803) is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol.
T3109	SP600125	129-56-6	99.58%
T3109	SP600125 (JNK Inhibitor II) is a JNK inhibitor that inhibits JNK1, JNK2, and JNK3 (IC50=40/40/90 nM) with oral potency, reversibility, and ATP-competitive proper...
T4414	Eprenetapopt	5291-32-7	99.57%
T4414	Eprenetapopt (PRIMA-1Met) restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenopr...
T0214	Pioglitazone	111025-46-8	99.57%
T0214	Pioglitazone (U 72107) is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked...
T0477	Zileuton	111406-87-2	99.56%
T0477	Zileuton (A 64077) is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which cataly...
T6500	Ferrostatin-1	347174-05-4	99.51%
T6500	Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of iron death. Ferrostatin-1 potently inhibits Erastin-induced iron death in HT-1080 cells with an EC50...
T1487	Fluvastatin sodium	93957-55-2	99.46%
T1487	Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol lower...
T2376	Liproxstatin-1	950455-15-9	99.44%
T2376	Liproxstatin-1 is a potent and selective inhibitor of iron death (IC50=22 nM). Liproxstatin-1 protects cells from iron death induced by iron death inducers (e.g....