FGFR

The fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast growth factor (FGF) family of proteins. Some of these receptors are involved in pathological conditions. For example, a point mutation in FGFR3 can lead to achondroplasia.

Cat. No.	Product name	CAS No.	Purity
T7104	Dovitinib lactate	692737-80-7	100%
T7104	Dovitinib lactate(TKI258) lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) (IC50 :5 nM).
T15185	Lucitanib	1058137-23-7	96.13%
T15185	Lucitanib is a novel VEGFR and FGFR inhibitor. It potently and selectively inhibits VEGFR1, VEGFR2, VEGFR3, FGFR1 and FGFR2 (IC50s: 7 nM, 25 nM, 10 nM, 17.5 nM, ...
T8976	PD-089828	179343-17-0	96.78%
T8976	PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 µM, respectively) and a noncompetitiv...
T5044	Futibatinib	1448169-71-8	97.34%
T5044	TAS-120 is a novel, potent and highly selective FGFR inhibitor, used for antitumor treatment.
T4235	Roblitinib	1708971-55-4	97.36%
T4235	FGF401 is an inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration, FGF401 binds to and inh...
T3274	S49076	1265965-22-7	97.4%
T3274	S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3, blocking cellular phosphorylation of MET, AXL, and FGFRs.
T3466	FIIN-3	1637735-84-2	97.7%
T3466	FIIN-3 is an irreversible inhibitor of FGFR.
T2358	ENMD-2076	934353-76-1	98%
T2358	ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.
T6184	Orantinib	252916-29-3	98.01%
T6184	TSU-68, a excellent effective against PDGFR autophosphorylation with Ki of 8 nM, also highly inhibits Flk-1 and FGFR1 trans-phosphorylation. It shows little effe...
T2642	PD173074	219580-11-7	98.21%
T2642	PD173074 is an effective FGFR1 inhibitor (IC50: 25 nM) and also inhibits VEGFR2 (IC50: 100-200 nM) in cell-free assays. The selectivity is higher ~1000-fold for ...
T6028	PF 477736	952021-60-2	98.34%
T6028	PF-477736 is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CSF1R), Ret and Yes.
T3714	SUN11602	704869-38-5	98.43%
T3714	SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor. It mimics the neuroprotective effects of bFGF and prevent...
T2094	Danusertib	827318-97-8	98.44%
T2094	Danusertib is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity. Danusertib binds to and inhibits the Aurora kinases, which may ...
T1975	Infigratinib	872511-34-7	98.46%
T1975	Infigratinib (BGJ398) is an orally bioavailable pan FGFR inhibitor (IC50: 0.9/1.4/1 nM for FGFR1/2/3), >40-fold selective for FGFR versus FGFR4 and VEGFR2.
T7611	ODM-203	1430723-35-5	98.77%
T7611	ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity
T6024	Zoligratinib	1265229-25-1	98.94%
T6024	CH5183284 is a selective and orally available FGFR inhibitor, which is for FGFR1(IC50=9.3 nM), FGFR2(IC50=7.6 nM), FGFR3(IC50=290), and FGFR4(IC50=22 nM), respec...
TQ0256	FGFR4-IN-1	1708971-72-5	98.96%
TQ0256	FGFR4-IN-1 is a potent FGFR4 inhibitor (IC50: 0.7 nM).
T3726	Erdafitinib	1346242-81-6	99.01%
T3726	Erdafitinib is a quinoxaline derivative compound, acts on FGFR1/2/3/4.
T6338	PHA-680632	398493-79-3	99.03%
T6338	PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGF...
T11279	FGFR1/DDR2 inhibitor 1	2308497-58-5	99.14%
T11279	FGFR1/DDR2 inhibitor 1 is an inhibitor of discoindin domain receptor 2 (DDR2) and fibroblast growth factor receptor 1 (FGFR1), with IC50 values of 31.1 nM, 108....