T7104 |
Dovitinib lactate
|
692737-80-7
|
100%
|
|
Dovitinib lactate(TKI258) lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) (IC50 :5 nM).
|
T15185 |
Lucitanib
|
1058137-23-7
|
96.13%
|
|
Lucitanib is a novel VEGFR and FGFR inhibitor. It potently and selectively inhibits VEGFR1, VEGFR2, VEGFR3, FGFR1 and FGFR2 (IC50s: 7 nM, 25 nM, 10 nM, 17.5 nM, ...
|
T8976 |
PD-089828
|
179343-17-0
|
96.78%
|
|
PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 µM, respectively) and a noncompetitiv...
|
T5044 |
Futibatinib
|
1448169-71-8
|
97.34%
|
|
TAS-120 is a novel, potent and highly selective FGFR inhibitor, used for antitumor treatment.
|
T4235 |
Roblitinib
|
1708971-55-4
|
97.36%
|
|
FGF401 is an inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration, FGF401 binds to and inh...
|
T3274 |
S49076
|
1265965-22-7
|
97.4%
|
|
S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3, blocking cellular phosphorylation of MET, AXL, and FGFRs.
|
T3466 |
FIIN-3
|
1637735-84-2
|
97.7%
|
|
FIIN-3 is an irreversible inhibitor of FGFR.
|
T2358 |
ENMD-2076
|
934353-76-1
|
98%
|
|
ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.
|
T6184 |
Orantinib
|
252916-29-3
|
98.01%
|
|
TSU-68, a excellent effective against PDGFR autophosphorylation with Ki of 8 nM, also highly inhibits Flk-1 and FGFR1 trans-phosphorylation. It shows little effe...
|
T2642 |
PD173074
|
219580-11-7
|
98.21%
|
|
PD173074 is an effective FGFR1 inhibitor (IC50: 25 nM) and also inhibits VEGFR2 (IC50: 100-200 nM) in cell-free assays. The selectivity is higher ~1000-fold for ...
|
T6028 |
PF 477736
|
952021-60-2
|
98.34%
|
|
PF-477736 is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CSF1R), Ret and Yes.
|
T3714 |
SUN11602
|
704869-38-5
|
98.43%
|
|
SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor. It mimics the neuroprotective effects of bFGF and prevent...
|
T2094 |
Danusertib
|
827318-97-8
|
98.44%
|
|
Danusertib is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity. Danusertib binds to and inhibits the Aurora kinases, which may ...
|
T1975 |
Infigratinib
|
872511-34-7
|
98.46%
|
|
Infigratinib (BGJ398) is an orally bioavailable pan FGFR inhibitor (IC50: 0.9/1.4/1 nM for FGFR1/2/3), >40-fold selective for FGFR versus FGFR4 and VEGFR2.
|
T7611 |
ODM-203
|
1430723-35-5
|
98.77%
|
|
ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity
|
T6024 |
Zoligratinib
|
1265229-25-1
|
98.94%
|
|
CH5183284 is a selective and orally available FGFR inhibitor, which is for FGFR1(IC50=9.3 nM), FGFR2(IC50=7.6 nM), FGFR3(IC50=290), and FGFR4(IC50=22 nM), respec...
|
TQ0256 |
FGFR4-IN-1
|
1708971-72-5
|
98.96%
|
|
FGFR4-IN-1 is a potent FGFR4 inhibitor (IC50: 0.7 nM).
|
T3726 |
Erdafitinib
|
1346242-81-6
|
99.01%
|
|
Erdafitinib is a quinoxaline derivative compound, acts on FGFR1/2/3/4.
|
T6338 |
PHA-680632
|
398493-79-3
|
99.03%
|
|
PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGF...
|
T11279 |
FGFR1/DDR2 inhibitor 1
|
2308497-58-5
|
99.14%
|
|
FGFR1/DDR2 inhibitor 1 is an inhibitor of discoindin domain receptor 2 (DDR2) and fibroblast growth factor receptor 1 (FGFR1), with IC50 values of 31.1 nM, 108....
|