T14685 |
BMS-986158
|
1800340-40-2
|
98.77%
|
|
BMS-986158 is a potent BET inhibitor with IC50s of 6.6 and 5 nM in NCI-H211 small cell lung cancer (SCLC) cells and MDA-MB231 triple negative breast cancer (TNBC...
|
T15784 |
LP99
|
1808951-93-0
|
98.74%
|
|
LP99 is an epigenetic probe. LP99 disrupts the binding of BRD7 and BRD9 to chromatin in cells. LP99 is an effective and selective inhibitor of the BRD7 and BRD9 ...
|
T9221 |
UNC926 hydrochloride
|
1782573-49-2
|
98.71%
|
|
UNC926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor.
|
T12943 |
SNDX-5613
|
2169919-21-3
|
98.7%
|
|
SNDX-5613 is a potent and specific inhibitor of Menin-MLL(Ki of 0.149 nM and a cell based IC50 of 10-20 nM). SNDX-5613 can be used for the research of MLL-rearra...
|
T9749 |
FHD-286
|
2671128-05-3
|
98.7%
|
|
FHD-286 is an inhibitor of BRM/BRG1 ATPase and can be used for studies on the treatment of BAF-related disorders such as acute myeloid leukemia.
|
T2237 |
ICG001
|
847591-62-2
|
98.63%
|
|
ICG001 (PRI-724 isomer) antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CREB)-binding protein (CBP) with ...
|
T10879 |
CPI-0610 carboxylic acid
|
1380089-81-5
|
98.62%
|
|
CPI-0610 carboxylic acid is an effective and selective small molecule inhibitor of bromine domain and outer end (BET) protein as a ligand of PROTAC target protei...
|
T8658 |
NEO2734
|
2081072-29-7
|
98.56%
|
|
NEO2734 (EP31670) is an orally active and selective inhibitor of p300/CBP and BET bromodomain(IC50 of <30 nM for both p300/CBP and BET bromodomains).
|
T3624 |
A-366
|
1527503-11-2
|
98.53%
|
|
A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.It is more than...
|
T19935 |
XD14
|
1370888-71-3
|
98.4%
|
|
XD14 is an inhibitor of BET bromodomain (Kd of 160 nM, 170 nM, 380 nM, 490 nM, 830 nM and 850 nM for BRD4(1), BRD2(1), BRD3(1), BRD3(2), BRD2(2) and BRD4(2), res...
|
T3504 |
AZD5153 6-Hydroxy-2-naphthoic acid
|
1869912-40-2
|
98.36%
|
|
AZD5153 6-Hydroxy-2-naphthoic acid (AZD5153) is a potent triazolopyridazine-based Bromodomain (BRD4) and Extraterminal (BET) inhibitor used in cancer treatments....
|
T6021 |
GSK1324726A
|
1300031-52-0
|
98.34%
|
|
GSK1324726A (I-BET726) is a greatly specific inhibitor of BET family proteins for BRD2(IC50=41 nM), BRD3(IC50=31 nM), and BRD4 (IC50=22 nM).
|
T14547 |
JWG-071
|
2250323-50-1
|
98.33%
|
|
JWG-071, the first reported chemical probe for ERK5 kinase selectivity, is a BET-selective inhibitor with a 1 μM BRD4 IC that enhances both ERK5 activity and BRD...
|
T14073 |
A-485
|
1889279-16-6
|
98.32%
|
|
A-485 is a potent and selective catalytic p300/CBP inhibitor(IC50s of 9.8 nM and 2.6 nM for p300 and CBP, respectively).
|
T9373 |
DCH36_06
|
593273-05-3
|
98.32%
|
|
DCH36_06 ((5E)-1-(3-chloro-4-methylphenyl)-5-[(2E)-3-(furan-2-yl)prop-2-en-1-ylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione) as a bona fide is a potent p30...
|
T13336 |
VTP50469
|
2169916-18-9
|
98.31%
|
|
VTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity.
|
T6173 |
BI 2536
|
755038-02-9
|
98.31%
|
|
BI2536 is an effective Plk1 inhibitor (IC50: 0.83 nM). It has 4- and 11-fold greater selectivity than Plk2 and Plk3.
|
T2072 |
BET bromodomain inhibitor
|
1505453-59-7
|
98.22%
|
|
BET bromodomain inhibitor is a potent BET inhibitor.
|
T4697 |
ABBV-744
|
2138861-99-9
|
98.2%
|
|
ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2/3/4. It is used in the research on inflammatory diseases, cancer, and AIDS.
|
T1843 |
XMD8-92
|
1234480-50-2
|
98.19%
|
|
XMD8-92 is an effective and specific BMK1/ERK5 inhibitor (Kd: 80 nM).
|