Epigenetic Reader Domain

Epigenetic reader domains can be thought of as effector proteins that recognize and are recruited to specific epigenetic marks.

Cat. No.	Product name	CAS No.	Purity
T6389	Anacardic Acid	16611-84-0	99.72%
T6389	Anacardic Acid is an effective inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases. It also has antimicrobial activity, antibacterial acti...
T2091	CPI0610	1380087-89-7	99.73%
T2091	CPI-0610 is an effective, specific, and cell-active BET bromodomain inhibitor CPI-0610 inhibits BRD4-BD1 (IC50: nM).
TQ0253	PLX51107	1627929-55-8	99.75%
TQ0253	PLX51107 is a potent and selective BET inhibitor (Kds: 1.6, 2.1, 1.7, and 5 nM for BRD2-BD1, BRD3-BD1, BRD4-BD1, and BRDT-BD1).
T8609	CHEMBRDG-BB 7118966	328956-24-7	99.76%
T8609	CHEMBRDG-BB 7118966 is an inhibitor of Bromodomain-containing protein 4 (human).
T5318	666-15	1433286-70-4	99.77%
T5318	666-15 is a potent and selective CREB inhibitor (IC50: 81 nM).
T3624	A-366	1527503-11-2	99.8%
T3624	Potent and selective G9a/GLP histone lysine methyltransferase inhibitor (IC50 = 3.3 nM). Exhibits >1000-fold selectivity for G9a/GLP over 21 other methyltransfer...
T17311	(+)-JQ1 PA	2115701-93-2	99.8%
T17311	(+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1(IC50 of 10.4 nM).
T60079	GNE-064	1997321-20-6	99.81%
T60079	GNE-064 is a selective, orally active and highly soluble inhibitor of SMARCA4, SMARCA2 and PBRM1 bromodomains 5. GNE-064 inhibits SMARCA4 with an IC50 of 0.035 μ...
T9194	UMB298	2266569-73-5	99.83%
T9194	UMB298 is a potent and selective CBP/P300 bromodomain inhibitor. UMB298 inhibits BRD4 with IC50 of 5193nM.
T6908	NSC 228155	113104-25-9	99.84%
T6908	NSC228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.
T8774	MS7972	352553-42-5	99.84%
T8774	MS7972 is CREBBP inhibitor that blocks human p53 and CREB binding protein association. MS7972 can almost completely block this BRD interaction at 50 μM
T9568	SGC-SMARCA-BRDVIII	1997319-84-2	99.85%
T9568	SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM, respect...
T7856	Naphthol AS-E	92-78-4	99.85%
T7856	nAS-E is an the KIX-KID interaction and CREB-mediated gene transcription inhibitor.
T8601	1-benzyl-2-ethyl-4,5,6,7-tetrahydro-1H-indol-4-one	218934-50-0	99.86%
T8601	1-benzyl-2-ethyl-4,5,6,7-tetrahydro-1H-indol-4-one is an inhibitor Bromodomain-containing protein 4 (human).
T13974	ZL0580	2377151-10-3	99.87%
T13974	ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV pr...
T60032	BRM/BRG1 ATP Inhibitor-2	2368900-77-8	99.88%
T60032	BRM/BRG1 ATP Inhibitor-2 is an inhibitor of BRG1/BRM ATPase and can be used in studies about the treatment of BAF-related disorders.
T9020	GSK620	2088410-46-0	99.88%
T9020	GSK620 is a pan-BD2 inhibitor, which shows an anti-inflammatory phenotype in human whole blood with excellent broad selectivity, developability, and in vivo oral...
T16154	MS417	916489-36-6	99.88%
T16154	MS417 is an inhibitor of BET-specific BRD4(BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively), with weak selectivity at CBP BR...
T12111L	MS31 trihydrochloride (2366264-12-0 free base)	T12111L	99.88%
T12111L	MS31 trihydrochloride is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor.
T2436	GSK2801	1619994-68-1	99.88%
T2436	GSK2801 is an effective, specific and cell active acetyl-lysine competitive inhibitor of BAZ2A(Kd: 136 nM) and BAZ2B(Kd: 257 nM) bromodomains.