T2480 |
Apabetalone
|
1044870-39-4
|
99%
|
|
RVX-208, an effective BET bromodomain inhibitor, has been investigated for the treatment of diabetes, atherosclerosis, and coronary artery disease.
|
T3217 |
PF-CBP1 hydrochloride
|
2070014-93-4
|
99%
|
|
PF-CBP1 is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM r...
|
T6668 |
SGC-CBP30
|
1613695-14-9
|
99.03%
|
|
SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).
|
T2379 |
UNC1215
|
1415800-43-9
|
99.04%
|
|
UNC1215, an effective and specific MBT (malignant brain tumor) antagonist, binds L3MBTL3 (IC50/Kd: 40/120 nM). The selectivity of UNC1215 for L3MBTL3 is 50-fold ...
|
T3697 |
3',6-Disinapoylsucrose
|
139891-98-8
|
99.07%
|
|
3, 6'-Disinapoyl sucrose shows the neuroprotective effect and antidepressive activity in rats.
|
T6584 |
MG 149
|
1243583-85-8
|
99.1%
|
|
MG149 is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF(IC50= 47 uM).
|
T3969 |
I-CBP112
|
1640282-31-0
|
99.1%
|
|
I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains.
|
T3311 |
GSK6853
|
1910124-24-1
|
99.11%
|
|
GSK6853 is a potent, soluble, cell-active, and highly selective inhibitor of the BRPF1 bromodomain.
|
T5130 |
DBET6
|
1950634-92-0
|
99.12%
|
|
dBET6 is a selective and cell-permeable degrader of BET based on PROTAC (IC50: 14 nM). It has antitumor activity.
|
T2442 |
CPI203
|
202591-23-9
|
99.13%
|
|
CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).
|
T6809 |
CPI-169 racemate
|
1450655-76-1
|
99.14%
|
|
CPI-169 is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively.
|
T5468 |
YF-2
|
1311423-89-8
|
99.19%
|
|
YF-2 is blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, CBP, PCAF, and GCN5 with EC50s of 2.75 μM, 29.04 μM...
|
T2452 |
C646
|
328968-36-1
|
99.21%
|
|
C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay).
|
T4345 |
CeMMEC1
|
440662-09-9
|
99.26%
|
|
CeMMEC1 is an inhibitor of BRD4, and also has a great affinity for TAF1(IC50=0.9 μM).
|
T2072 |
BET bromodomain inhibitor
|
1505453-59-7
|
99.26%
|
|
BET bromodomain inhibitor is a potent BET inhibitor.
|
T6859 |
I-BRD9
|
1714146-59-4
|
99.28%
|
|
I-BRD9 is the first selective cellular inhibitor for BRD9 with pIC50 of 7.3.
|
TQ0058 |
MI-463
|
1628317-18-9
|
99.28%
|
|
MI-463 is a potent and orally bioavailable inhibitor of the menin-mLL interaction (IC50: 15.3 nM).
|
T8778 |
TTK21
|
709676-56-2
|
99.3%
|
|
TTK21 is an activator of CBP/p300 histone acetyltransferase activity.
|
T4495 |
DBET1
|
1799711-21-9
|
99.3%
|
|
dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apopt...
|
T8453 |
UNC1079
|
1418741-86-2
|
99.31%
|
|
UNC1079 is an selective L3MBTL3 domain inhibitor
|