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Epigenetic Reader Domain

Epigenetic reader domains can be thought of as effector proteins that recognize and are recruited to specific epigenetic marks.
Cat. No. Product name CAS No. Purity Chemical Structure
T2480 Apabetalone 1044870-39-4 99%
RVX-208, an effective BET bromodomain inhibitor, has been investigated for the treatment of diabetes, atherosclerosis, and coronary artery disease.
T3217 PF-CBP1 hydrochloride 2070014-93-4 99%
PF-CBP1 is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM r...
T6668 SGC-CBP30 1613695-14-9 99.03%
SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).
T2379 UNC1215 1415800-43-9 99.04%
UNC1215, an effective and specific MBT (malignant brain tumor) antagonist, binds L3MBTL3 (IC50/Kd: 40/120 nM). The selectivity of UNC1215 for L3MBTL3 is 50-fold ...
T3697 3',6-Disinapoylsucrose 139891-98-8 99.07%
3, 6'-Disinapoyl sucrose shows the neuroprotective effect and antidepressive activity in rats.
T6584 MG 149 1243583-85-8 99.1%
MG149 is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF(IC50= 47 uM).
T3969 I-CBP112 1640282-31-0 99.1%
I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains.
T3311 GSK6853 1910124-24-1 99.11%
GSK6853 is a potent, soluble, cell-active, and highly selective inhibitor of the BRPF1 bromodomain.
T5130 DBET6 1950634-92-0 99.12%
dBET6 is a selective and cell-permeable degrader of BET based on PROTAC (IC50: 14 nM). It has antitumor activity.
T2442 CPI203 202591-23-9 99.13%
CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).
T6809 CPI-169 racemate 1450655-76-1 99.14%
CPI-169 is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively.
T5468 YF-2 1311423-89-8 99.19%
YF-2 is blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, CBP, PCAF, and GCN5 with EC50s of 2.75 μM, 29.04 μM...
T2452 C646 328968-36-1 99.21%
C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay).
T4345 CeMMEC1 440662-09-9 99.26%
CeMMEC1 is an inhibitor of BRD4, and also has a great affinity for TAF1(IC50=0.9 μM).
T2072 BET bromodomain inhibitor 1505453-59-7 99.26%
BET bromodomain inhibitor is a potent BET inhibitor.
T6859 I-BRD9 1714146-59-4 99.28%
I-BRD9 is the first selective cellular inhibitor for BRD9 with pIC50 of 7.3.
TQ0058 MI-463 1628317-18-9 99.28%
MI-463 is a potent and orally bioavailable inhibitor of the menin-mLL interaction (IC50: 15.3 nM).
T8778 TTK21 709676-56-2 99.3%
TTK21 is an activator of CBP/p300 histone acetyltransferase activity.
T4495 DBET1 1799711-21-9 99.3%
dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apopt...
T8453 UNC1079 1418741-86-2 99.31%
UNC1079 is an selective L3MBTL3 domain inhibitor
Apabetalone
T2480
RVX-208, an effective BET bromodomain inhibitor, has been investigated for the treatment of diabetes, atherosclerosis, and coronary artery disease.
PF-CBP1 hydrochloride
T3217
PF-CBP1 is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM r...
SGC-CBP30
T6668
SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).
UNC1215
T2379
UNC1215, an effective and specific MBT (malignant brain tumor) antagonist, binds L3MBTL3 (IC50/Kd: 40/120 nM). The selectivity of UNC1215 for L3MBTL3 is 50-fold ...
3',6-Disinapoylsucrose
T3697
3, 6'-Disinapoyl sucrose shows the neuroprotective effect and antidepressive activity in rats.
MG 149
T6584
MG149 is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF(IC50= 47 uM).
I-CBP112
T3969
I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains.
GSK6853
T3311
GSK6853 is a potent, soluble, cell-active, and highly selective inhibitor of the BRPF1 bromodomain.
dBET6
T5130
dBET6 is a selective and cell-permeable degrader of BET based on PROTAC (IC50: 14 nM). It has antitumor activity.
CPI203
T2442
CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).
CPI-169 racemate
T6809
CPI-169 is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively.
YF-2
T5468
YF-2 is blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, CBP, PCAF, and GCN5 with EC50s of 2.75 μM, 29.04 μM...
C646
T2452
C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay).
CeMMEC1
T4345
CeMMEC1 is an inhibitor of BRD4, and also has a great affinity for TAF1(IC50=0.9 μM).
BET bromodomain inhibitor
T2072
BET bromodomain inhibitor is a potent BET inhibitor.
I-BRD9
T6859
I-BRD9 is the first selective cellular inhibitor for BRD9 with pIC50 of 7.3.
MI-463
TQ0058
MI-463 is a potent and orally bioavailable inhibitor of the menin-mLL interaction (IC50: 15.3 nM).
TTK21
T8778
TTK21 is an activator of CBP/p300 histone acetyltransferase activity.
dBET1
T4495
dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apopt...
UNC1079
T8453
UNC1079 is an selective L3MBTL3 domain inhibitor
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