Epigenetic Reader Domain

Epigenetic reader domains can be thought of as effector proteins that recognize and are recruited to specific epigenetic marks.

Cat. No.	Product name	CAS No.	Purity
T2480	Apabetalone	1044870-39-4	99%
T2480	RVX-208, an effective BET bromodomain inhibitor, has been investigated for the treatment of diabetes, atherosclerosis, and coronary artery disease.
T3217	PF-CBP1 hydrochloride	2070014-93-4	99%
T3217	PF-CBP1 is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM r...
T6668	SGC-CBP30	1613695-14-9	99.03%
T6668	SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).
T2379	UNC1215	1415800-43-9	99.04%
T2379	UNC1215, an effective and specific MBT (malignant brain tumor) antagonist, binds L3MBTL3 (IC50/Kd: 40/120 nM). The selectivity of UNC1215 for L3MBTL3 is 50-fold ...
T3697	3',6-Disinapoylsucrose	139891-98-8	99.07%
T3697	3, 6'-Disinapoyl sucrose shows the neuroprotective effect and antidepressive activity in rats.
T6584	MG 149	1243583-85-8	99.1%
T6584	MG149 is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF(IC50= 47 uM).
T3969	I-CBP112	1640282-31-0	99.1%
T3969	I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains.
T3311	GSK6853	1910124-24-1	99.11%
T3311	GSK6853 is a potent, soluble, cell-active, and highly selective inhibitor of the BRPF1 bromodomain.
T5130	DBET6	1950634-92-0	99.12%
T5130	dBET6 is a selective and cell-permeable degrader of BET based on PROTAC (IC50: 14 nM). It has antitumor activity.
T2442	CPI203	202591-23-9	99.13%
T2442	CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).
T6809	CPI-169 racemate	1450655-76-1	99.14%
T6809	CPI-169 is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively.
T5468	YF-2	1311423-89-8	99.19%
T5468	YF-2 is blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, CBP, PCAF, and GCN5 with EC50s of 2.75 μM, 29.04 μM...
T2452	C646	328968-36-1	99.21%
T2452	C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay).
T4345	CeMMEC1	440662-09-9	99.26%
T4345	CeMMEC1 is an inhibitor of BRD4, and also has a great affinity for TAF1(IC50=0.9 μM).
T2072	BET bromodomain inhibitor	1505453-59-7	99.26%
T2072	BET bromodomain inhibitor is a potent BET inhibitor.
T6859	I-BRD9	1714146-59-4	99.28%
T6859	I-BRD9 is the first selective cellular inhibitor for BRD9 with pIC50 of 7.3.
TQ0058	MI-463	1628317-18-9	99.28%
TQ0058	MI-463 is a potent and orally bioavailable inhibitor of the menin-mLL interaction (IC50: 15.3 nM).
T8778	TTK21	709676-56-2	99.3%
T8778	TTK21 is an activator of CBP/p300 histone acetyltransferase activity.
T4495	DBET1	1799711-21-9	99.3%
T4495	dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apopt...
T8453	UNC1079	1418741-86-2	99.31%
T8453	UNC1079 is an selective L3MBTL3 domain inhibitor