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Inhibitors Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation JAK/STAT signaling
MAPK Membrane transporter/Ion channel Metabolism Microbiology/Virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome Stem Cells Tyrosine Kinase/Adaptors Ubiquitination Others
Compound Libraries Focused Bioactive Libraries General Bioactive Libraries Approved / Repurposing Disease Focused Target / Pathway Focused Characteristic Bioactive Libraries Natural Product Libraries Natural Product Library for HTS Characteristic Natural Product Libraries Natural Product Derivatives Libraries Natural Product Library for CADD Drug-like Compound Libraries Fragment Libraries Custom Compound Library
Signaling Pathways Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling
DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation JAK/STAT signaling MAPK Membrane transporter/Ion channel
Metabolism Microbiology/Virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome
Stem Cells Tyrosine Kinase/Adaptors Ubiquitination
Focused Bioactive Libraries General Bioactive Libraries Approved / Repurposing Disease Focused Target / Pathway Focused Characteristic Bioactive Libraries
Natural Product Libraries Natural Product Library for HTS Characteristic Natural Product Libraries Natural Product Derivatives Libraries Natural Product Library for CADD
Drug-like Compound Libraries Compound Libraries for HTS/HCS
Fragment Libraries General Fragment Libraries Characteristic Fragment Libraries Custom Compound Library

Epigenetic Reader Domain

Epigenetic reader domains can be thought of as effector proteins that recognize and are recruited to specific epigenetic marks.
Cat. No. Product name CAS No. Purity Chemical Structure
T6113 ICG-001 780757-88-2 98%
ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CBP) with IC50 of 3 μM, but is not the related tr...
T13363 Y06137 2226534-49-0 98%
Y06137 is an effective and selective BET inhibitor with a Kd of 81 nM for BRD4(1) bromodomain. Y06137 can be used for research on the treatment of castration-res...
T9370 DCBP-1 2484739-25-3 98%
dCBP-1 is a chemical degrader of p300/CBP. dCBP-1 hijacks the E3 ubiquitin ligase CRBN for selective degradation of p300/CBP. Degradation of p300/CBP by dCBP-1 l...
T9629 WAY-309060 309951-18-6 98%
WAY-309060 is a BRD4 small molecule inhibitor with antitumor activity.
T10641 C-82 1422253-37-9 98%
C-82 is a specific CBP/β-catenin antagonist. It inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300.
T27392 FT001 1778655-51-8 98%
FT001 is a potent, selective and orally available inhibitor of BET Bromodomain with antitumor activity. FT001 inhibited the expression of MYC with the IC50 value...
T17697 BRD7-IN-1 2448414-48-8 98%
BRD7-IN-1 is a modified derivative of BI7273 (BRD7/9 inhibitor) that binds to a VHL ligand via a linker to form a PROTAC VZ185 (VZ185 against BRD7/9 with DC 50 s...
T15405 GNE-781 1936422-33-1 98%
GNE-781 is a highly potent and selective inhibitor of CBP (IC50: 0.94 nM in TR-FRET assay). GNE-781 also inhibits BRET and BRD4(1) (IC50s: 6.2 nM and 5100 nM, re...
T9373 DCH36_06 593273-05-3
DCH36_06  as a bona fide is a potent p300/CBP inhibitor
T9399 Menin-MLL inhibitor 20 2448173-47-3
Menin-MLL inhibitor 20 is an irreversible inhibitor of menin-MLL interaction with antitumor activities (WO2020142557A1, compound 6).
T16321 NI-42 1884640-99-6
NI-42 is a structurally orthogonal chemical probe for the BRPFs and is biased. It effective inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; ...
T11563 Histone Acetyltransferase Inhibitor II 932749-62-7 100%
Histone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 µM).with anti-acetylase activity in...
TQ0083 NI-57 1883548-89-7 100%
NI-57 is an inhibitor of proteins of bromodomain and plant homeodomain finger-containing (BRPF) family, with IC50s of 3.1, 46 and 140 nM for BRPF1, BRPF2 (BRD1) ...
T15216 EML 425 1675821-32-5 100%
EML 425 is a potent and selective inhibitor of CREB binding protein (CBP)/p300 (IC50s: 2.9 and 1.1 μM, respectively).
T12112 MS402 1672684-68-2 100%
MS402 is a novel BD1-selective BET BrD inhibitor.
T4365 FL-411 2118944-88-8 96.23%
FL-411 is a potent and selective BRD4 inhibitor with an IC50 of 0.43±0.09 μM for BRD4.
T4012 UNC926 1184136-10-4 96.97%
UNC-926 inhibits L3MBTL1 (IC50: 3.9 μM). UNC-926 also exhibits a low micromolar affinity for L3MBTL3. UNC-926 inhibits binding of the 3xMBT domain to H4K20me1. I...
T6889 MI-136 1628316-74-4 97.08%
MI-136 inhibits expression of androgen receptor (AR) target genes that DHT induced.
T13394 ZEN-3862 1952264-33-3 97.1%
ZEN-3862 is an inhibitor of BET(IC50s of 0.16 and 0.13 μM for BRD4(BD1) and BRD4(BD2) , respectively). ZEN-3862 can be used to form PROTACs to induce degradation...
T10717 Inobrodib 2222941-37-7 97.36%
CBP-IN-1 is a potent inhibitor of p300/CBP bromodomain.
ICG-001
T6113
ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CBP) with IC50 of 3 μM, but is not the related tr...
Y06137
T13363
Y06137 is an effective and selective BET inhibitor with a Kd of 81 nM for BRD4(1) bromodomain. Y06137 can be used for research on the treatment of castration-res...
dCBP-1
T9370
dCBP-1 is a chemical degrader of p300/CBP. dCBP-1 hijacks the E3 ubiquitin ligase CRBN for selective degradation of p300/CBP. Degradation of p300/CBP by dCBP-1 l...
WAY-309060
T9629
WAY-309060 is a BRD4 small molecule inhibitor with antitumor activity.
C-82
T10641
C-82 is a specific CBP/β-catenin antagonist. It inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300.
FT001
T27392
FT001 is a potent, selective and orally available inhibitor of BET Bromodomain with antitumor activity. FT001 inhibited the expression of MYC with the IC50 value...
BRD7-IN-1
T17697
BRD7-IN-1 is a modified derivative of BI7273 (BRD7/9 inhibitor) that binds to a VHL ligand via a linker to form a PROTAC VZ185 (VZ185 against BRD7/9 with DC 50 s...
GNE-781
T15405
GNE-781 is a highly potent and selective inhibitor of CBP (IC50: 0.94 nM in TR-FRET assay). GNE-781 also inhibits BRET and BRD4(1) (IC50s: 6.2 nM and 5100 nM, re...
DCH36_06
T9373
DCH36_06  as a bona fide is a potent p300/CBP inhibitor
Menin-MLL inhibitor 20
T9399
Menin-MLL inhibitor 20 is an irreversible inhibitor of menin-MLL interaction with antitumor activities (WO2020142557A1, compound 6).
NI-42
T16321
NI-42 is a structurally orthogonal chemical probe for the BRPFs and is biased. It effective inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; ...
Histone Acetyltransferase Inhibitor II
T11563
Histone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 µM).with anti-acetylase activity in...
NI-57
TQ0083
NI-57 is an inhibitor of proteins of bromodomain and plant homeodomain finger-containing (BRPF) family, with IC50s of 3.1, 46 and 140 nM for BRPF1, BRPF2 (BRD1) ...
EML 425
T15216
EML 425 is a potent and selective inhibitor of CREB binding protein (CBP)/p300 (IC50s: 2.9 and 1.1 μM, respectively).
MS402
T12112
MS402 is a novel BD1-selective BET BrD inhibitor.
FL-411
T4365
FL-411 is a potent and selective BRD4 inhibitor with an IC50 of 0.43±0.09 μM for BRD4.
UNC926
T4012
UNC-926 inhibits L3MBTL1 (IC50: 3.9 μM). UNC-926 also exhibits a low micromolar affinity for L3MBTL3. UNC-926 inhibits binding of the 3xMBT domain to H4K20me1. I...
MI-136
T6889
MI-136 inhibits expression of androgen receptor (AR) target genes that DHT induced.
ZEN-3862
T13394
ZEN-3862 is an inhibitor of BET(IC50s of 0.16 and 0.13 μM for BRD4(BD1) and BRD4(BD2) , respectively). ZEN-3862 can be used to form PROTACs to induce degradation...
Inobrodib
T10717
CBP-IN-1 is a potent inhibitor of p300/CBP bromodomain.
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