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Epigenetic Reader Domain

Epigenetic reader domains can be thought of as effector proteins that recognize and are recruited to specific epigenetic marks.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T15484 HJB97 2093391-24-1 98%
HJB97
HJB97 is used for the design of potential PROTAC BET degrader. It also has antitumor activity. HJB97 is a high-affinity inhibitor of BET (Kis: 0.9 nM (BRD2 BD1)...
T12660L BAY1238097 1564268-08-1 98%
BAY1238097
BAY1238097 is a potent and selective bromodomain and extra-terminal motif (BET) inhibitor with anticancer activity that exhibits strong antiproliferative activit...
T13715L GSK9311 1923851-49-3 98%
GSK9311
GSK9311 inhibits BRPF bromodomain (pIC50: 6.0 and 4.3 for BRPF1 and BRPF2, respectively). GSK9311 is a less active analog of GSK6853. It can be used as a negativ...
T13086 I-BET762 carboxylic acid 1300019-38-8 98%
I-BET762 carboxylic acid
I-BET762 carboxylic acid is an inhibitor of BRD4(pIC50 of 5.1).
T13190 TP-472 2079895-62-6 98%
TP-472
TP-472 is a selective inhibitor of BRD9 (Kd: 33 nM).
T17147 TPOP146 2018300-62-2 98%
TPOP146
TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor (Kd: 134 nM and 5.02 μM for CBP and BRD4).
T12798 (S)-GNE-987 T12798 98%
(S)-GNE-987
(S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).
T11887 LT052 2543545-44-2 98%
LT052
LT052 is a highly active and selective inhibitor of BET BD1 with an IC 50 of 87.7 nM. LT052 exhibits nanomolar BRD4 BD1 potency and 138-fold selectivity over BRD...
T13834 PROTAC BRD4 Degrader-2 2185795-53-1 98%
PROTAC BRD4 Degrader-2
PROTAC BRD4 Degrader-2 is an efficacious degrader of PROTAC BRD4(BRD4 BD1,IC50 of 14.2 nM).
T13786 MZP-55 2010159-48-3 98%
MZP-55
MZP-55 is a selective BRD3/4 degrader based on PROTAC technology(Brd4BD2 with Kd of 8 nM)
T12113 MS645 2250091-96-2 98%
MS645
MS645 is an inhibitor of bromodomain-containing protein 4 (BRD4) with a Ki of 18.4 nM for BRD4-BD1/BD2.
T13915 PROTAC BRD9-binding moiety 1 2097512-23-5 98%
PROTAC BRD9-binding moiety 1
PROTAC BRD9-binding moiety 1 that binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC.
TP2149L NP213 942577-31-3 98%
NP213
NP213 is a rapidly acting synthetic antimicrobial peptide (AMP). NP213 is effective and well-tolerated in resolving nail fungal infections. NP213 has anti-fungal...
T12660 (Rac)-BAY1238097 1564268-19-4 98%
(Rac)-BAY1238097
(Rac)-BAY1238097 is a inhibitor of BET(IC50 of 1.02 μM for BRD4),used in cancer research.
T10522 BET-IN-6 2570470-39-0 98%
BET-IN-6
BET-IN-6 is a potent and high affnity BRD2/BRD4 inhibitor. BET-IN-6 is the ligand for target protein BRD2/4 that is used for the systhesis of PROTAC BRD2/BRD4 de...
T13105 TD-428 T13105 98%
TD-428
TD-428 is a highly specific degrader of BRD4(DC50 of 0.32 nM). TD-428 is a BET PROTAC, which comprises TD-106 (a CRBN ligand) linked to JQ1 (a BET inhibitor). TD...
T13833 PROTAC BRD4 Degrader-1 2133360-00-4 98%
PROTAC BRD4 Degrader-1
PROTAC BRD4 Degrader-1 is an efficacious degrader of BRD4(BRD4 BD1,IC50 of 41.8 nM).
T16139 MRS2698 934014-05-8 98%
MRS2698
MRS2698 is an effective and highly selective agonist of the P2Y2 receptor (EC50: 8 nM). MRS2698 also is >300-fold P2Y2-selective versus the P2Y4 and P2Y6 recepto...
T13715 GSK9311 hydrochloride 2253733-09-2 98%
GSK9311 hydrochloride
GSK9311 hydrochloride, a less active analog of GSK6853, can be used as a negative control. GSK9311 hydrochloride inhibits BRPF bromodomain (pIC50s: 6.0 and 4.3 f...
T10702 CBP/p300-IN-2 2158265-96-2 98%
CBP/p300-IN-2
CBP/EP300-IN-2 is an inhibitor of CBP/EP300 (IC50s: 1.07 nM and 5.96 nM for CBP/HTRF and Myc) extracted from patent WO2017205538A1 (example 25).
HJB97
T15484
HJB97 is used for the design of potential PROTAC BET degrader. It also has antitumor activity. HJB97 is a high-affinity inhibitor of BET (Kis: 0.9 nM (BRD2 BD1)...
BAY1238097
T12660L
BAY1238097 is a potent and selective bromodomain and extra-terminal motif (BET) inhibitor with anticancer activity that exhibits strong antiproliferative activit...
GSK9311
T13715L
GSK9311 inhibits BRPF bromodomain (pIC50: 6.0 and 4.3 for BRPF1 and BRPF2, respectively). GSK9311 is a less active analog of GSK6853. It can be used as a negativ...
I-BET762 carboxylic acid
T13086
I-BET762 carboxylic acid is an inhibitor of BRD4(pIC50 of 5.1).
TP-472
T13190
TP-472 is a selective inhibitor of BRD9 (Kd: 33 nM).
TPOP146
T17147
TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor (Kd: 134 nM and 5.02 μM for CBP and BRD4).
(S)-GNE-987
T12798
(S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).
LT052
T11887
LT052 is a highly active and selective inhibitor of BET BD1 with an IC 50 of 87.7 nM. LT052 exhibits nanomolar BRD4 BD1 potency and 138-fold selectivity over BRD...
PROTAC BRD4 Degrader-2
T13834
PROTAC BRD4 Degrader-2 is an efficacious degrader of PROTAC BRD4(BRD4 BD1,IC50 of 14.2 nM).
MZP-55
T13786
MZP-55 is a selective BRD3/4 degrader based on PROTAC technology(Brd4BD2 with Kd of 8 nM)
MS645
T12113
MS645 is an inhibitor of bromodomain-containing protein 4 (BRD4) with a Ki of 18.4 nM for BRD4-BD1/BD2.
PROTAC BRD9-binding moiety 1
T13915
PROTAC BRD9-binding moiety 1 that binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC.
NP213
TP2149L
NP213 is a rapidly acting synthetic antimicrobial peptide (AMP). NP213 is effective and well-tolerated in resolving nail fungal infections. NP213 has anti-fungal...
(Rac)-BAY1238097
T12660
(Rac)-BAY1238097 is a inhibitor of BET(IC50 of 1.02 μM for BRD4),used in cancer research.
BET-IN-6
T10522
BET-IN-6 is a potent and high affnity BRD2/BRD4 inhibitor. BET-IN-6 is the ligand for target protein BRD2/4 that is used for the systhesis of PROTAC BRD2/BRD4 de...
TD-428
T13105
TD-428 is a highly specific degrader of BRD4(DC50 of 0.32 nM). TD-428 is a BET PROTAC, which comprises TD-106 (a CRBN ligand) linked to JQ1 (a BET inhibitor). TD...
PROTAC BRD4 Degrader-1
T13833
PROTAC BRD4 Degrader-1 is an efficacious degrader of BRD4(BRD4 BD1,IC50 of 41.8 nM).
MRS2698
T16139
MRS2698 is an effective and highly selective agonist of the P2Y2 receptor (EC50: 8 nM). MRS2698 also is >300-fold P2Y2-selective versus the P2Y4 and P2Y6 recepto...
GSK9311 hydrochloride
T13715
GSK9311 hydrochloride, a less active analog of GSK6853, can be used as a negative control. GSK9311 hydrochloride inhibits BRPF bromodomain (pIC50s: 6.0 and 4.3 f...
CBP/p300-IN-2
T10702
CBP/EP300-IN-2 is an inhibitor of CBP/EP300 (IC50s: 1.07 nM and 5.96 nM for CBP/HTRF and Myc) extracted from patent WO2017205538A1 (example 25).
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TargetMol