T15441 |
GSK8573
|
1693766-04-9
|
98%
|
|
GSK8573 is an inactive control compound for GSK2801. GSK8573 has binding activity to BRD9 (Kd of 1.04 μM).
|
T13785 |
MZP-54
|
2010159-47-2
|
98%
|
|
MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology(Kd of 4 nM for Brd4BD2)
|
T15400 |
GNE-272
|
1936428-93-1
|
98%
|
|
GNE-272 is a selective inhibitor of CBP/EP300 (IC50: 0.02, 0.03, and 13 μM for CBP, EP300, and BRD4, respectively) and a selective in vivo probe for CBP/EP300.
|
T12798 |
(S)-GNE-987
|
T12798
|
98%
|
|
(S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).
|
T41180 |
JQAD1
|
2417097-18-6
|
98%
|
|
JQAD1 is a potent and selective histone acetyltransferase EP300 degrader (PROTAC®; DC50≤ 31.6 nM); comprises an EP300 inhibitor, A485, joined by a linker to a ce...
|
T15419 |
GS-626510
|
1637770-13-8
|
98%
|
|
GS-626510 is an orally bioavailable inhibitor of BET family bromodomains (Kd: 0.59-3.2 nM for BRD2/3/4; IC50: 83 nM and 78 nM for BD1 and BD2).
|
T13715L |
GSK9311
|
1923851-49-3
|
98%
|
|
GSK9311 inhibits BRPF bromodomain (pIC50: 6.0 and 4.3 for BRPF1 and BRPF2, respectively). GSK9311 is a less active analog of GSK6853. It can be used as a negativ...
|
T14512 |
BAZ2-ICR
|
1665195-94-7
|
98%
|
|
BAZ2-ICR is an epigenetic chemical probe and it also is a potent, selective, cell active and orally active BAZ2A/B bromodomains inhibitor with IC50s of 130 nM an...
|
T13190 |
TP-472
|
2079895-62-6
|
98%
|
|
TP-472 is a selective inhibitor of BRD9 (Kd: 33 nM).
|
T12560 |
PROTAC BRD9 Degrader-1
|
2097971-01-0
|
98%
|
|
PROTAC BRD9 Degrader-1 is a lead PROTAC BRD9 chemical degrader with IC50 of 13.5 nM.
|
T11597L |
IACS-9571 Hydrochloride (1800477-30-8 free base)
|
T11597L
|
98%
|
|
IACS-9571 Hydrochloride is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1).
|
T13835 |
PROTAC BRD4 Degrader-3
|
2313234-00-1
|
98%
|
|
PROTAC BRD4 Degrader-3 is an efficacious degrader of PROTAC BRD4.
|
T17147 |
TPOP146
|
2018300-62-2
|
98%
|
|
TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor (Kd: 134 nM and 5.02 μM for CBP and BRD4).
|
T13392 |
ZEN-3219
|
1952264-34-4
|
98%
|
|
ZEN-3219 is a BET inhibitor, which has inhibitory effect on BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2). ZEN-3219 has inhibitory effect on BRD4(BD1), The IC50 values o...
|
T17294 |
ZL0454
|
2229042-77-5
|
98%
|
|
ZL0454 is an effective and selective Bromodomain-containing protein 4 inhibitors (IC50: 49 and 32 nM for BD1 and BD2).
|
T16139 |
MRS2698
|
934014-05-8
|
98%
|
|
MRS2698 is an effective and highly selective agonist of the P2Y2 receptor (EC50: 8 nM). MRS2698 also is >300-fold P2Y2-selective versus the P2Y4 and P2Y6 recepto...
|
T11597 |
IACS-9571
|
1800477-30-8
|
98%
|
|
IACS-9571 is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1).
|
T11292 |
FKBP12 PROTAC dTAG-7
|
2064175-32-0
|
98%
|
|
FKBP12 PROTAC dTAG-7 (dTAG-7) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin l...
|
T36395 |
Trotabresib
|
1706738-98-8
|
98%
|
|
CC-90010 is an orally active inhibitor of BET and can be used in studies about advanced solid tumors.
|
T12551 |
PROTAC BRD4 ligand-1
|
2313230-51-0
|
98%
|
|
PROTAC BRD4 ligand-1 is a ligand for BRD4 for Protac GNE-987 and an inhibitor of BET.
|