T6824 |
EAI045
|
1942114-09-1
|
98%
|
|
EAI045, an allosteric inhibitor, targets towards drug-resistant EGFR mutants but avoids the wild-type receptor.
|
T4528 |
Tyrphostin AG 528
|
133550-49-9
|
98%
|
|
Tyrphostin AG 528 is an inhibitor of EGFR (IC50: 4.9 μM) and ErbB2 (IC50: 2.1 μM).
|
T12542 |
Rilzabrutinib
|
1575596-29-0
|
98%
|
|
PRN1008 is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK)(IC50 of 1.3 nM).
|
T3721 |
Avitinib maleate
|
1557268-88-8
|
98%
|
|
Avitinib maleate is a pyrrolopyrimidine-based irreversible epidermal growth factor receptor (EGFR) inhibitor.
|
T2307 |
Icotinib Hydrochloride
|
1204313-51-8
|
98%
|
|
Icotinib Hydrochloride is the hydrochloride salt form of icotinib, an orally available quinazoline-based inhibitor of EGFR, with potential antineoplastic activit...
|
T2630 |
Poziotinib
|
1092364-38-9
|
98%
|
|
Poziotinib(NOV120101; HM781-36B) is an irreversible HER1/2/4 inhibitor (IC50s: 3/5/23 nM).
|
T0373L |
Erlotinib hydrochloride
|
183319-69-9
|
98%
|
|
Erlotinib is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.
|
T3554 |
RG14620
|
136831-49-7
|
98%
|
|
RG14620 is an epidermal growth factor receptor (EGFR) inhibitor.
|
T11157L |
EGFR-IN-1 hydrochloride
|
2227455-78-7
|
98%
|
|
EGFR-IN-1 hydrochloride is an irreversible and specific inhibitor of L858R/T790M mutant EGFR with 100-fold selectivity over wild-type EGFR. EGFR-IN-1 hydrochlori...
|
T7175 |
Alflutinib mesylate
|
2130958-55-1
|
98%
|
|
AST2818 mesylate,is an irreversible tyrosine kinase inhibitor that selectively inhibits EGFR mutations, especially T790M.
|
T2280 |
Endoxifen (Z-isomer)
|
112093-28-4
|
98%
|
|
Endoxifen (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase activity.
|
T2851 |
Daphnetin
|
486-35-1
|
98%
|
|
Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM), ...
|
T6092 |
Sapitinib
|
848942-61-0
|
98%
|
|
AZD8931, a reversible, ATP competitive inhibitor of EGFR(IC50=4 nM), ErbB2(IC50=3 nM) and ErbB3(IC50=4 nM), is more effective over Gefitinib or Lapatinib against...
|
T2490 |
Osimertinib
|
1421373-65-0
|
98%
|
|
Osimertinib is a small molecule tyrosine kinase receptor inhibitor and antineoplastic agent that is used in the therapy of selected forms of advanced non-small c...
|
T6908 |
NSC 228155
|
113104-25-9
|
98%
|
|
NSC228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.
|
T5462 |
Almonertinib
|
1899921-05-1
|
98%
|
|
Hs-10296 is an inhibitor of EGFR activation mutation and tolerant mutation of EGFR T790M, which has only limited activity against wild-type EGFR.
|
T34656 |
SKLB 1028
|
1350544-93-2
|
98%
|
|
SKLB1028 is a new type of oral multikinase inhibitor of EGFR, FLT3, and Abl. It shows excellent activity in FLT3-driven AML models and considerable potency in CM...
|
T13619 |
Cloperastine fendizoate
|
85187-37-7
|
98%
|
|
Cloperastine fendizoate inhibits the hERG K+ currents in a concentration-dependent manner (IC50: 27 nM).
|
T10419 |
AV-412
|
451493-31-5
|
98%
|
|
AV-412 is an EGFR inhibitor (EGFR, EGFR T790M, EGFR L858R, EGFR L858R/T790M and ErbB2 with IC50s of 0.75, 0.79, 0.5, 2.3, 19 nM).
|
T6427 |
Butein
|
487-52-5
|
98%
|
|
Butein, a plant polyphenol, is isolated from Rhus verniciflua. It can inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, and also can inhibit EG...
|