EGFR

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.

Cat. No.	Product name	CAS No.	Purity
T6824	EAI045	1942114-09-1	98%
T6824	EAI045, an allosteric inhibitor, targets towards drug-resistant EGFR mutants but avoids the wild-type receptor.
T4528	Tyrphostin AG 528	133550-49-9	98%
T4528	Tyrphostin AG 528 is an inhibitor of EGFR (IC50: 4.9 μM) and ErbB2 (IC50: 2.1 μM).
T12542	Rilzabrutinib	1575596-29-0	98%
T12542	PRN1008 is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK)(IC50 of 1.3 nM).
T3721	Avitinib maleate	1557268-88-8	98%
T3721	Avitinib maleate is a pyrrolopyrimidine-based irreversible epidermal growth factor receptor (EGFR) inhibitor.
T2307	Icotinib Hydrochloride	1204313-51-8	98%
T2307	Icotinib Hydrochloride is the hydrochloride salt form of icotinib, an orally available quinazoline-based inhibitor of EGFR, with potential antineoplastic activit...
T2630	Poziotinib	1092364-38-9	98%
T2630	Poziotinib(NOV120101; HM781-36B) is an irreversible HER1/2/4 inhibitor (IC50s: 3/5/23 nM).
T0373L	Erlotinib hydrochloride	183319-69-9	98%
T0373L	Erlotinib is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.
T3554	RG14620	136831-49-7	98%
T3554	RG14620 is an epidermal growth factor receptor (EGFR) inhibitor.
T11157L	EGFR-IN-1 hydrochloride	2227455-78-7	98%
T11157L	EGFR-IN-1 hydrochloride is an irreversible and specific inhibitor of L858R/T790M mutant EGFR with 100-fold selectivity over wild-type EGFR. EGFR-IN-1 hydrochlori...
T7175	Alflutinib mesylate	2130958-55-1	98%
T7175	AST2818 mesylate,is an irreversible tyrosine kinase inhibitor that selectively inhibits EGFR mutations, especially T790M.
T2280	Endoxifen (Z-isomer)	112093-28-4	98%
T2280	Endoxifen (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase activity.
T2851	Daphnetin	486-35-1	98%
T2851	Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM), ...
T6092	Sapitinib	848942-61-0	98%
T6092	AZD8931, a reversible, ATP competitive inhibitor of EGFR(IC50=4 nM), ErbB2(IC50=3 nM) and ErbB3(IC50=4 nM), is more effective over Gefitinib or Lapatinib against...
T2490	Osimertinib	1421373-65-0	98%
T2490	Osimertinib is a small molecule tyrosine kinase receptor inhibitor and antineoplastic agent that is used in the therapy of selected forms of advanced non-small c...
T6908	NSC 228155	113104-25-9	98%
T6908	NSC228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.
T5462	Almonertinib	1899921-05-1	98%
T5462	Hs-10296 is an inhibitor of EGFR activation mutation and tolerant mutation of EGFR T790M, which has only limited activity against wild-type EGFR.
T34656	SKLB 1028	1350544-93-2	98%
T34656	SKLB1028 is a new type of oral multikinase inhibitor of EGFR, FLT3, and Abl. It shows excellent activity in FLT3-driven AML models and considerable potency in CM...
T13619	Cloperastine fendizoate	85187-37-7	98%
T13619	Cloperastine fendizoate inhibits the hERG K+ currents in a concentration-dependent manner (IC50: 27 nM).
T10419	AV-412	451493-31-5	98%
T10419	AV-412 is an EGFR inhibitor (EGFR, EGFR T790M, EGFR L858R, EGFR L858R/T790M and ErbB2 with IC50s of 0.75, 0.79, 0.5, 2.3, 19 nM).
T6427	Butein	487-52-5	98%
T6427	Butein, a plant polyphenol, is isolated from Rhus verniciflua. It can inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, and also can inhibit EG...