DNA/RNA Synthesis

RNA synthesis, which is also called DNA transcription, is a highly selective process. Transcription by RNA polymerase II extends beyond RNA synthesis, towards a more active role in mRNA maturation, surveillance and export to the cytoplasm. Single-strand breaks are repaired by DNA ligase using the complementary strand of the double helix as a template, with DNA ligase creating the final phosphodiester bond to fully repair the DNA.DNA ligases discriminate against substrates containing RNA strands or mismatched base pairs at positions near the ends of the nickedDNA. Bleomycin (BLM) exerts its genotoxicity by generating free radicals, whichattack C-4′ in the deoxyribose backbone of DNA, leading to opening of the ribose ring and strand breakage; it is an S-independentradiomimetic agent that causes double-strand breaks in DNA.

Cat. No.	Product name	CAS No.	Purity
T5413	ML216	1430213-30-1	96.83%
T5413	ML-216 is a small molecule inhibitor of BLM helicase (IC50: 1.8 μM). It showed 28-fold selective against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC...
T7525	Didox	69839-83-4	96.85%
T7525	Didox is a synthetic ribonucleotide reductase (RR) inhibitor that has been found to reduce the levels of oxidative injury markers in the brains of HIV patients w...
T3524	Halofuginone hydrobromide	64924-67-0	97.01%
T3524	Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of...
TN2132	Quinizarin	81-64-1	97.02%
TN2132	Quinizarin is a natural product
T0062	Folic acid	59-30-3	97.02%
T0062	Folic acid(Vitamin M; Vitamin B9) is indispensable for the production and maintenance of new cells, for DNA/RNA synthesis.
T10104	3,4-Dihydroxybenzylamine hydrobromide	16290-26-9	97.28%
T10104	3,4-Dihydroxybenzylamine hydrobromide inhibits DNA polymerase activity in melanoma cells and displays growth inhibitory activity in melanoma cell lines with vary...
T16911	Sorivudine	77181-69-2	97.33%
T16911	Sorivudine is an orally active synthetic pyrimidine nucleoside antimetabolite drug. Sorivudine derives its antiviral activity from selective conversion by a spec...
T0681	Rifampicin	13292-46-1	97.36%
T0681	Rifampicin is an antibacterial drug of the class of rifamycin.
TN1016	Kukoamine A	75288-96-9	97.45%
TN1016	Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, it also has neuroprotective effects through inhibiting oxidative...
T1507	Streptozocin	18883-66-4	97.49%
T1507	Streptozotocin is an antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animal...
T36757	DMT-dU-CE Phosphoramidite	109389-30-2	97.58%
T36757	DMT-dU-CE Phosphoramidite is a nucleoside molecule commonly used for the synthesis and sequencing of DNA.
T6856	Halofuginone	55837-20-2	97.67%
T6856	Halofuginone, the competitive inhibitor of prolyl-tRNA synthetase（Ki=18.3 nM）, could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mamm...
T4228	Nolatrexed	147149-76-6	97.91%
T4228	Nolatrexed is a thymidylate synthase inhibitor with potential anticancer activity.
T6801	CeMMEC13	1790895-25-8	97.95%
T6801	CeMMEC13 is an isoquinolinone that selectively inhibits the second bromodomain of TAF1 (IC50 = 2.1 μM).
T7409	360A	794458-56-3	98%
T7409	360A is a stabilizing G-Quadruplex ligand, and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM).
T6501	Fludarabine Phosphate	75607-67-9	98%
T6501	Fludarabine Phosphate is the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activ...
T6456	CRT0044876	6960-45-8	98%
T6456	CRT0044876 is a potent and selective APE1 inhibitor with IC50 of ~3 μM.
T7518	Deoxycytidine triphosphate trisodium salt	109909-44-6	98%
T7518	2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE TRISODI Oxidation contributes to antibiotic lethality in stationary-phase mycobacteria.
T4356	POL1-IN-1	1822358-25-7	98%
T4356	Compound 3A can effectively inhibit the transcription of RNA polymerase I in the A375 malignant melanoma cell line but has no effect on polymerase II.
T1840	Isoindigotin	476-34-6	98%
T1840	Isoindigotin is used in the therapy of Y.