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DNA/RNA Synthesis

RNA synthesis, which is also called DNA transcription, is a highly selective process. Transcription by RNA polymerase II extends beyond RNA synthesis, towards a more active role in mRNA maturation, surveillance and export to the cytoplasm. Single-strand breaks are repaired by DNA ligase using the complementary strand of the double helix as a template, with DNA ligase creating the final phosphodiester bond to fully repair the DNA.DNA ligases discriminate against substrates containing RNA strands or mismatched base pairs at positions near the ends of the nickedDNA. Bleomycin (BLM) exerts its genotoxicity by generating free radicals, whichattack C-4′ in the deoxyribose backbone of DNA, leading to opening of the ribose ring and strand breakage; it is an S-independentradiomimetic agent that causes double-strand breaks in DNA.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T0926 Azelaic acid 123-99-9 99.89%
Azelaic acid
Azelaic acid (Anchoic acid) is bactericidal against Propionibacterium acnes and Staphylococcus epidermidis due to its inhibitory effect on the synthesis of micro...
T6357 (S)-crizotinib 1374356-45-2 99.89%
(S)-crizotinib
(S)-crizotinib (ent-crizotinib) (IC50 of 72 nM), an effective MTH1 (NUDT1) inhibitor, is the (S)-enantiomer of crizotinib.
T9271 RAD51-IN-1 2101739-18-6 99.87%
RAD51-IN-1
Rad51-in-1 is a derivative of B02 and an effective inhibitor of Rad51.
TN1244 3'-Demethylnobiletin 112448-39-2 99.87%
3'-Demethylnobiletin
3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle a...
T0717 Enoxacin hydrate 84294-96-2 99.86%
Enoxacin hydrate
Enoxacin hydrate (AT-2266 hydrate) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.
T4226 Amenamevir 841301-32-4 99.86%
Amenamevir
Amenamevir (ASP2151) is a novel helicase-primase inhibitor that is active against varicella-zoster virus and herpes simplex virus types 1 and 2 (EC50: 14 ng/mL)....
T2219 Puromycin dihydrochloride 58-58-2 99.86%
Puromycin dihydrochloride
Puromycin dihydrochloride (CL13900 dihydrochloride) is a cinnamamide adenosine antibiotic and an inhibitor of protein synthesis. Puromycin dihydrochloride inhibi...
T0676 Hydroxyurea 127-07-1 99.85%
Hydroxyurea
Hydroxyurea (Hydroxycarbamide), an antineoplastic agent, inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
T6069 Gemcitabine hydrochloride 122111-03-9 99.85%
Gemcitabine hydrochloride
Gemcitabine hydrochloride (LY 188011 hydrochloride) is a DNA synthesis inhibitor (IC50s: 12, 18, 40, 92.7, 89.3 in Capan2, BxPC-3, Mia Paca-2, PANC-1, and PL-45 ...
T6908 NSC 228155 113104-25-9 99.84%
NSC 228155
NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.
T11020 DHODH-IN-11 1263303-95-2 99.84%
DHODH-IN-11
DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.
T1724 SCR7 pyrazine 14892-97-8 99.83%
SCR7 pyrazine
SCR7 pyrazine (SCR7) enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro up to 19-fold. Inhibits nonhomologous end-joining (NHEJ).
T0986 Flucytosine 2022-85-7 99.83%
Flucytosine
Flucytosine (NSC 103805) is a pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity.
T3658 Trifluridine/tipiracil hydrochloride mixture 733030-01-8 99.82%
Trifluridine/tipiracil hydrochloride mixture
Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a novel oral combination drug containing trifluridine (TFT) and Tipiracil hydrochloride (TTP) in a mola...
T0684 Ribavirin 36791-04-5 99.82%
Ribavirin
Ribavirin (Tribavirin) is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
T28918 Talviraline 163451-80-7 99.82%
Talviraline
Talviraline (Bay 10-8979) is an RNA-induced DNA polymerase inhibitor.Talviraline is a potent inhibitor of HIV-1-induced cell killing and HIV-1 replication in a v...
T1153 Trimethoprim 738-70-5 99.81%
Trimethoprim
Trimethoprim (NSC-106568) is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor...
T3103 L67 325970-71-6 99.79%
L67
L67 (DNA Ligase Inhibitor) is a competitive human DNA ligase inhibitor, inhibits DNA ligases I and III (IC50: 10 μM).
T0125 Epirubicin hydrochloride 56390-09-1 99.79%
Epirubicin hydrochloride
Epirubicin hydrochloride (Pharmorubicin) is an antineoplastic agent which can inhibit Topoisomerase.
T60037 SR15006 2505001-54-5 99.78%
SR15006
SR15006 is Krüppel-like factor 5 (KLF5) inhibitor (IC50 = 41.6 nM).
Azelaic acid
T0926
Azelaic acid (Anchoic acid) is bactericidal against Propionibacterium acnes and Staphylococcus epidermidis due to its inhibitory effect on the synthesis of micro...
(S)-crizotinib
T6357
(S)-crizotinib (ent-crizotinib) (IC50 of 72 nM), an effective MTH1 (NUDT1) inhibitor, is the (S)-enantiomer of crizotinib.
RAD51-IN-1
T9271
Rad51-in-1 is a derivative of B02 and an effective inhibitor of Rad51.
3'-Demethylnobiletin
TN1244
3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle a...
Enoxacin hydrate
T0717
Enoxacin hydrate (AT-2266 hydrate) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.
Amenamevir
T4226
Amenamevir (ASP2151) is a novel helicase-primase inhibitor that is active against varicella-zoster virus and herpes simplex virus types 1 and 2 (EC50: 14 ng/mL)....
Puromycin dihydrochloride
T2219
Puromycin dihydrochloride (CL13900 dihydrochloride) is a cinnamamide adenosine antibiotic and an inhibitor of protein synthesis. Puromycin dihydrochloride inhibi...
Hydroxyurea
T0676
Hydroxyurea (Hydroxycarbamide), an antineoplastic agent, inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
Gemcitabine hydrochloride
T6069
Gemcitabine hydrochloride (LY 188011 hydrochloride) is a DNA synthesis inhibitor (IC50s: 12, 18, 40, 92.7, 89.3 in Capan2, BxPC-3, Mia Paca-2, PANC-1, and PL-45 ...
NSC 228155
T6908
NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.
DHODH-IN-11
T11020
DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.
SCR7 pyrazine
T1724
SCR7 pyrazine (SCR7) enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro up to 19-fold. Inhibits nonhomologous end-joining (NHEJ).
Flucytosine
T0986
Flucytosine (NSC 103805) is a pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity.
Trifluridine/tipiracil hydrochloride mixture
T3658
Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a novel oral combination drug containing trifluridine (TFT) and Tipiracil hydrochloride (TTP) in a mola...
Ribavirin
T0684
Ribavirin (Tribavirin) is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
Talviraline
T28918
Talviraline (Bay 10-8979) is an RNA-induced DNA polymerase inhibitor.Talviraline is a potent inhibitor of HIV-1-induced cell killing and HIV-1 replication in a v...
Trimethoprim
T1153
Trimethoprim (NSC-106568) is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor...
L67
T3103
L67 (DNA Ligase Inhibitor) is a competitive human DNA ligase inhibitor, inhibits DNA ligases I and III (IC50: 10 μM).
Epirubicin hydrochloride
T0125
Epirubicin hydrochloride (Pharmorubicin) is an antineoplastic agent which can inhibit Topoisomerase.
SR15006
T60037
SR15006 is Krüppel-like factor 5 (KLF5) inhibitor (IC50 = 41.6 nM).
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TargetMol