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DNA/RNA Synthesis

RNA synthesis, which is also called DNA transcription, is a highly selective process. Transcription by RNA polymerase II extends beyond RNA synthesis, towards a more active role in mRNA maturation, surveillance and export to the cytoplasm. Single-strand breaks are repaired by DNA ligase using the complementary strand of the double helix as a template, with DNA ligase creating the final phosphodiester bond to fully repair the DNA.DNA ligases discriminate against substrates containing RNA strands or mismatched base pairs at positions near the ends of the nickedDNA. Bleomycin (BLM) exerts its genotoxicity by generating free radicals, whichattack C-4′ in the deoxyribose backbone of DNA, leading to opening of the ribose ring and strand breakage; it is an S-independentradiomimetic agent that causes double-strand breaks in DNA.
Cat. No. Product name CAS No. Purity Chemical Structure
T5413 ML216 1430213-30-1 96.83%
ML-216 is a small molecule inhibitor of BLM helicase (IC50: 1.8 μM). It showed 28-fold selective against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC...
T7525 Didox 69839-83-4 96.85%
Didox is a synthetic ribonucleotide reductase (RR) inhibitor that has been found to reduce the levels of oxidative injury markers in the brains of HIV patients w...
T3524 Halofuginone hydrobromide 64924-67-0 97.01%
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of...
TN2132 Quinizarin 81-64-1 97.02%
Quinizarin is a natural product
T0062 Folic acid 59-30-3 97.02%
Folic acid(Vitamin M; Vitamin B9) is indispensable for the production and maintenance of new cells, for DNA/RNA synthesis.
T10104 3,4-Dihydroxybenzylamine hydrobromide 16290-26-9 97.28%
3,4-Dihydroxybenzylamine hydrobromide inhibits DNA polymerase activity in melanoma cells and displays growth inhibitory activity in melanoma cell lines with vary...
T16911 Sorivudine 77181-69-2 97.33%
Sorivudine is an orally active synthetic pyrimidine nucleoside antimetabolite drug. Sorivudine derives its antiviral activity from selective conversion by a spec...
T0681 Rifampicin 13292-46-1 97.36%
Rifampicin is an antibacterial drug of the class of rifamycin.
TN1016 Kukoamine A 75288-96-9 97.45%
Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, it also has neuroprotective effects through inhibiting oxidative...
T1507 Streptozocin 18883-66-4 97.49%
Streptozotocin is an antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animal...
T36757 DMT-dU-CE Phosphoramidite 109389-30-2 97.58%
DMT-dU-CE Phosphoramidite is a nucleoside molecule commonly used for the synthesis and sequencing of DNA.
T6856 Halofuginone 55837-20-2 97.67%
Halofuginone, the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mamm...
T4228 Nolatrexed 147149-76-6 97.91%
Nolatrexed is a thymidylate synthase inhibitor with potential anticancer activity.
T6801 CeMMEC13 1790895-25-8 97.95%
CeMMEC13 is an isoquinolinone that selectively inhibits the second bromodomain of TAF1 (IC50 = 2.1 μM).
T7409 360A 794458-56-3 98%
360A is a stabilizing G-Quadruplex ligand, and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM).
T6501 Fludarabine Phosphate 75607-67-9 98%
Fludarabine Phosphate is the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activ...
T6456 CRT0044876 6960-45-8 98%
CRT0044876 is a potent and selective APE1 inhibitor with IC50 of ~3 μM.
T7518 Deoxycytidine triphosphate trisodium salt 109909-44-6 98%
2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE TRISODI Oxidation contributes to antibiotic lethality in stationary-phase mycobacteria.
T4356 POL1-IN-1 1822358-25-7 98%
Compound 3A can effectively inhibit the transcription of RNA polymerase I in the A375 malignant melanoma cell line but has no effect on polymerase II.
T1840 Isoindigotin 476-34-6 98%
Isoindigotin is used in the therapy of Y.
ML216
T5413
ML-216 is a small molecule inhibitor of BLM helicase (IC50: 1.8 μM). It showed 28-fold selective against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC...
Didox
T7525
Didox is a synthetic ribonucleotide reductase (RR) inhibitor that has been found to reduce the levels of oxidative injury markers in the brains of HIV patients w...
Halofuginone hydrobromide
T3524
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of...
Quinizarin
TN2132
Quinizarin is a natural product
Folic acid
T0062
Folic acid(Vitamin M; Vitamin B9) is indispensable for the production and maintenance of new cells, for DNA/RNA synthesis.
3,4-Dihydroxybenzylamine hydrobromide
T10104
3,4-Dihydroxybenzylamine hydrobromide inhibits DNA polymerase activity in melanoma cells and displays growth inhibitory activity in melanoma cell lines with vary...
Sorivudine
T16911
Sorivudine is an orally active synthetic pyrimidine nucleoside antimetabolite drug. Sorivudine derives its antiviral activity from selective conversion by a spec...
Rifampicin
T0681
Rifampicin is an antibacterial drug of the class of rifamycin.
Kukoamine A
TN1016
Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, it also has neuroprotective effects through inhibiting oxidative...
Streptozocin
T1507
Streptozotocin is an antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animal...
DMT-dU-CE Phosphoramidite
T36757
DMT-dU-CE Phosphoramidite is a nucleoside molecule commonly used for the synthesis and sequencing of DNA.
Halofuginone
T6856
Halofuginone, the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mamm...
Nolatrexed
T4228
Nolatrexed is a thymidylate synthase inhibitor with potential anticancer activity.
CeMMEC13
T6801
CeMMEC13 is an isoquinolinone that selectively inhibits the second bromodomain of TAF1 (IC50 = 2.1 μM).
360A
T7409
360A is a stabilizing G-Quadruplex ligand, and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM).
Fludarabine Phosphate
T6501
Fludarabine Phosphate is the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activ...
CRT0044876
T6456
CRT0044876 is a potent and selective APE1 inhibitor with IC50 of ~3 μM.
Deoxycytidine triphosphate trisodium salt
T7518
2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE TRISODI Oxidation contributes to antibiotic lethality in stationary-phase mycobacteria.
POL1-IN-1
T4356
Compound 3A can effectively inhibit the transcription of RNA polymerase I in the A375 malignant melanoma cell line but has no effect on polymerase II.
Isoindigotin
T1840
Isoindigotin is used in the therapy of Y.
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