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DNA/RNA Synthesis

RNA synthesis, which is also called DNA transcription, is a highly selective process. Transcription by RNA polymerase II extends beyond RNA synthesis, towards a more active role in mRNA maturation, surveillance and export to the cytoplasm. Single-strand breaks are repaired by DNA ligase using the complementary strand of the double helix as a template, with DNA ligase creating the final phosphodiester bond to fully repair the DNA.DNA ligases discriminate against substrates containing RNA strands or mismatched base pairs at positions near the ends of the nickedDNA. Bleomycin (BLM) exerts its genotoxicity by generating free radicals, whichattack C-4′ in the deoxyribose backbone of DNA, leading to opening of the ribose ring and strand breakage; it is an S-independentradiomimetic agent that causes double-strand breaks in DNA.
Cat. No. Product name CAS No. Purity Chemical Structure
T0164 Oxaliplatin 61825-94-3 98%
Oxaliplatin inhibits DNA synthesis by conforming DNA adducts.
T1272 Cytarabine 147-94-4 98%
Cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterical...
T4687 Ro5-3335 30195-30-3 98%
Ro 5-3335 is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM). It represses RUNX1/CBF...
T1378 Tegafur 17902-23-7 98%
Ftorafur is a congener of the antimetabolite fluorouracil with antineoplastic activity. Ftorafur is a prodrug that is gradually converted to fluorouracil in the ...
T3279 Silver sulfadiazine 22199-08-2 98%
Silver Sulfadiazine is a sulfonamide-based topical agent with antibacterial and antifungal activity.
T7766 Remdesivir 1809249-37-3 98%
Remdesivir is a nucleoside analogue, with effective antiviral activity( EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells)
T1600 Doxifluridine 3094-09-5 98%
Doxifluridine is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designe...
T0189 Pemetrexed 137281-23-3 98%
Pemetrexed, a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).
T0964 Floxuridine 50-91-9 98%
Floxuridine is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity.
T3343 5-methoxyflavone 42079-78-7 98%
5-methoxyflavone is a naturally occurring, low molecular weight flavonoids compound that associated with a wide wariety of biological activities.
T1703 SN-38 86639-52-3 98%
SN-38 is an active metabolite of CPT-11.
T6069 Gemcitabine hydrochloride 122111-03-9 98%
Gemcitabine is a DNA synthesis inhibitor (IC50s: 12, 18, 40, 92.7, 89.3 in Capan2, BxPC-3, Mia Paca-2, PANC-1, and PL-45 cells, respectively).
T6446 Clevudine 163252-36-6 98%
Clevudine is a synthetic pyrimidine analogue with activity against hepatitis B virus (HBV). Intracellularly, clevudine is phosphorylated to its active metabolite...
TMA0984 Cerevisterol 516-37-0 98%
Cerevisterol is a cytotoxic steroid, can inhibit the activity of DNA polymerase alpha. It can stimulate NGF-mediated neurite outgrowth on PC12 cells.
TN5153 Torilin 13018-10-5 98%
Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic...
TN4038 Eupatolide 6750-25-0 98%
Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast can...
Oxaliplatin
T0164
Oxaliplatin inhibits DNA synthesis by conforming DNA adducts.
Cytarabine
T1272
Cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterical...
Ro5-3335
T4687
Ro 5-3335 is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM). It represses RUNX1/CBF...
Tegafur
T1378
Ftorafur is a congener of the antimetabolite fluorouracil with antineoplastic activity. Ftorafur is a prodrug that is gradually converted to fluorouracil in the ...
Silver sulfadiazine
T3279
Silver Sulfadiazine is a sulfonamide-based topical agent with antibacterial and antifungal activity.
Remdesivir
T7766
Remdesivir is a nucleoside analogue, with effective antiviral activity( EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells)
Doxifluridine
T1600
Doxifluridine is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designe...
Pemetrexed
T0189
Pemetrexed, a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).
Floxuridine
T0964
Floxuridine is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity.
5-methoxyflavone
T3343
5-methoxyflavone is a naturally occurring, low molecular weight flavonoids compound that associated with a wide wariety of biological activities.
SN-38
T1703
SN-38 is an active metabolite of CPT-11.
Gemcitabine hydrochloride
T6069
Gemcitabine is a DNA synthesis inhibitor (IC50s: 12, 18, 40, 92.7, 89.3 in Capan2, BxPC-3, Mia Paca-2, PANC-1, and PL-45 cells, respectively).
Clevudine
T6446
Clevudine is a synthetic pyrimidine analogue with activity against hepatitis B virus (HBV). Intracellularly, clevudine is phosphorylated to its active metabolite...
Cerevisterol
TMA0984
Cerevisterol is a cytotoxic steroid, can inhibit the activity of DNA polymerase alpha. It can stimulate NGF-mediated neurite outgrowth on PC12 cells.
Torilin
TN5153
Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic...
Eupatolide
TN4038
Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast can...
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