DNA/RNA Synthesis

RNA synthesis, which is also called DNA transcription, is a highly selective process. Transcription by RNA polymerase II extends beyond RNA synthesis, towards a more active role in mRNA maturation, surveillance and export to the cytoplasm. Single-strand breaks are repaired by DNA ligase using the complementary strand of the double helix as a template, with DNA ligase creating the final phosphodiester bond to fully repair the DNA.DNA ligases discriminate against substrates containing RNA strands or mismatched base pairs at positions near the ends of the nickedDNA. Bleomycin (BLM) exerts its genotoxicity by generating free radicals, whichattack C-4′ in the deoxyribose backbone of DNA, leading to opening of the ribose ring and strand breakage; it is an S-independentradiomimetic agent that causes double-strand breaks in DNA.

Cat. No.	Product name	CAS No.	Purity
T0164	Oxaliplatin	61825-94-3	98%
T0164	Oxaliplatin inhibits DNA synthesis by conforming DNA adducts.
T1272	Cytarabine	147-94-4	98%
T1272	Cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterical...
T4687	Ro5-3335	30195-30-3	98%
T4687	Ro 5-3335 is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM). It represses RUNX1/CBF...
T1378	Tegafur	17902-23-7	98%
T1378	Ftorafur is a congener of the antimetabolite fluorouracil with antineoplastic activity. Ftorafur is a prodrug that is gradually converted to fluorouracil in the ...
T3279	Silver sulfadiazine	22199-08-2	98%
T3279	Silver Sulfadiazine is a sulfonamide-based topical agent with antibacterial and antifungal activity.
T7766	Remdesivir	1809249-37-3	98%
T7766	Remdesivir is a nucleoside analogue, with effective antiviral activity( EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells)
T1600	Doxifluridine	3094-09-5	98%
T1600	Doxifluridine is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designe...
T0189	Pemetrexed	137281-23-3	98%
T0189	Pemetrexed, a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).
T0964	Floxuridine	50-91-9	98%
T0964	Floxuridine is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity.
T3343	5-methoxyflavone	42079-78-7	98%
T3343	5-methoxyflavone is a naturally occurring, low molecular weight flavonoids compound that associated with a wide wariety of biological activities.
T1703	SN-38	86639-52-3	98%
T1703	SN-38 is an active metabolite of CPT-11.
T6069	Gemcitabine hydrochloride	122111-03-9	98%
T6069	Gemcitabine is a DNA synthesis inhibitor (IC50s: 12, 18, 40, 92.7, 89.3 in Capan2, BxPC-3, Mia Paca-2, PANC-1, and PL-45 cells, respectively).
T6446	Clevudine	163252-36-6	98%
T6446	Clevudine is a synthetic pyrimidine analogue with activity against hepatitis B virus (HBV). Intracellularly, clevudine is phosphorylated to its active metabolite...
TMA0984	Cerevisterol	516-37-0	98%
TMA0984	Cerevisterol is a cytotoxic steroid, can inhibit the activity of DNA polymerase alpha. It can stimulate NGF-mediated neurite outgrowth on PC12 cells.
TN5153	Torilin	13018-10-5	98%
TN5153	Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic...
TN4038	Eupatolide	6750-25-0	98%
TN4038	Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast can...