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Casein Kinase

The Casein kinase 1 family of protein kinases are serine/threonine-selective enzymes that function as regulators of signal transduction pathways in most eukaryotic cell types. CK1 isoforms are involved in Wnt signaling, circadian rhythms, nucleo-cytoplasmic shuttling of transcription factors, DNA repair, and DNA transcription.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T6315 MLN8054 869363-13-3 99.05%
MLN8054
MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.
T77500 Casein kinase 1δ-IN-6 1579991-01-7 99%
Casein kinase 1δ-IN-6
Casein kinase 1δ-IN-6 is a potent and selective inhibitor of the protein kinase CK-1δ with an IC50 of 23 nM.Casein kinase 1δ-IN-6 shows neuroprotective and anti-...
T10827 CK2/ERK8-IN-1 1085822-09-8 98.82%
CK2/ERK8-IN-1
CK2/ERK8-IN-1 (TMCB) is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds t...
T10687 Casein Kinase II Inhibitor IV 863598-09-8 98.81%
Casein Kinase II Inhibitor IV
Casein Kinase II Inhibitor IV is an inducer of epidermal keratinocyte differentiation.
T5393 CK1-IN-1 1784751-20-7 98.79%
CK1-IN-1
CK1-IN-1 (PUN51207) is a casein kinase 1 (CK1) inhibitor. CK1-IN-1 has IC50s of 15 nM, 16 nM, 73 nM for CK1δ, and CK1ε, p38σ MAPK, respectively.
T60005 CK1-IN-3 349438-74-0 98.70%
CK1-IN-3
CK1-IN-3 is casein kinase 1 (CK1) inhibitor and can be used for research on the treatment or prevention of diseases associated with circadiantiazol rhythm, infla...
T13004 SSTC3 1242422-09-8 98.65%
SSTC3
SSTC3 is a casein kinase 1α (CK1α) activator with a Kd of 32 nM.SSTC3 has potential antitumor activity, inhibits WNT signaling, and suppresses SHH medulloblastom...
T77708 Casein kinase 1δ-IN-7 764694-25-9 98.6%
Casein kinase 1δ-IN-7
Casein kinase 1δ-IN-7 is a Casein kinase 1δ inhibitor for neurodegenerative diseases such as Alzheimer's disease.
T12237 NMS-P715 1202055-32-0 98.41%
NMS-P715
NMS-P715 is a selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).
T5056 PF-4800567 1188296-52-7 98.23%
PF-4800567
PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ.
T7949 NCC007 2342583-66-6 98.11%
NCC007
NCC007 is a novel CKIα and CKIδ dual inhibitors by structural modification of N9 and C2 position of longdaysin.
T73269 CK2α-IN-1 443747-52-2 98%
CK2α-IN-1
CK2α-IN-1 is a selective non-ATP-competitive CK2α inhibitor with an IC50 of 7.0 µM and a Ki of 1.6 µM.CK2α-IN-1 exhibits potential anticancer activity and can be...
T1828 TTP 22 329907-28-0 97.78%
TTP 22
TTP 22 is a high affinity, ATP-competitive casein kinase 2 (CK2) inhibitor with IC50/Ki of 0.1 uM/40 nM, and shows selectivity >250-fold for CK2 over JNK3, ROCK1...
T10547 BioE-1115 1268863-35-9 97.38%
BioE-1115
BioE-1115 is a selective and potent inhibitor of serine-threonine protein kinase (PASK, IC50 = 4 nM). BioE-1115 is a potent inhibitor of CK2α (IC50 = 10 μM).
T2869 Emodin 518-82-1 94.4%
Emodin
Emodin (Frangula emodin) is a naturally occurring anthraquinone present in the roots and barks of numerous plants; exerts antiproliferative effects in Y cells th...
T19913 CKI-7 1177141-67-1 100.00%
CKI-7
CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ...
T3972 SR-3029 1454585-06-8 100%
SR-3029
SR-3029 is a potent and highly specific CK1δ/CK1ε inhibitor.
T8987 Epiblastin A 16470-02-3 100%
Epiblastin A
Epiblastin A is an inhibitor of Casein Kinase 1 (CK1). Epiblastin A engages CK1 isoenzymes in cell lysate and induces efficient conversion of epiblast stem cells...
T1877 LH846 639052-78-1
LH846
LH846 is a selective inhibitor of CK1δ (IC50 values are 290 nM, 1.3 uM and 2.5 uM for CK1δ, ε and α); exhibits no inhibitory activity at CK2.
T14072 A-443654 552325-16-3
A-443654
A-443654 is a pan-Akt inhibitor. A-443654 has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
MLN8054
T6315
MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.
Casein kinase 1δ-IN-6
T77500
Casein kinase 1δ-IN-6 is a potent and selective inhibitor of the protein kinase CK-1δ with an IC50 of 23 nM.Casein kinase 1δ-IN-6 shows neuroprotective and anti-...
CK2/ERK8-IN-1
T10827
CK2/ERK8-IN-1 (TMCB) is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds t...
Casein Kinase II Inhibitor IV
T10687
Casein Kinase II Inhibitor IV is an inducer of epidermal keratinocyte differentiation.
CK1-IN-1
T5393
CK1-IN-1 (PUN51207) is a casein kinase 1 (CK1) inhibitor. CK1-IN-1 has IC50s of 15 nM, 16 nM, 73 nM for CK1δ, and CK1ε, p38σ MAPK, respectively.
CK1-IN-3
T60005
CK1-IN-3 is casein kinase 1 (CK1) inhibitor and can be used for research on the treatment or prevention of diseases associated with circadiantiazol rhythm, infla...
SSTC3
T13004
SSTC3 is a casein kinase 1α (CK1α) activator with a Kd of 32 nM.SSTC3 has potential antitumor activity, inhibits WNT signaling, and suppresses SHH medulloblastom...
Casein kinase 1δ-IN-7
T77708
Casein kinase 1δ-IN-7 is a Casein kinase 1δ inhibitor for neurodegenerative diseases such as Alzheimer's disease.
NMS-P715
T12237
NMS-P715 is a selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).
PF-4800567
T5056
PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ.
NCC007
T7949
NCC007 is a novel CKIα and CKIδ dual inhibitors by structural modification of N9 and C2 position of longdaysin.
CK2α-IN-1
T73269
CK2α-IN-1 is a selective non-ATP-competitive CK2α inhibitor with an IC50 of 7.0 µM and a Ki of 1.6 µM.CK2α-IN-1 exhibits potential anticancer activity and can be...
TTP 22
T1828
TTP 22 is a high affinity, ATP-competitive casein kinase 2 (CK2) inhibitor with IC50/Ki of 0.1 uM/40 nM, and shows selectivity >250-fold for CK2 over JNK3, ROCK1...
BioE-1115
T10547
BioE-1115 is a selective and potent inhibitor of serine-threonine protein kinase (PASK, IC50 = 4 nM). BioE-1115 is a potent inhibitor of CK2α (IC50 = 10 μM).
Emodin
T2869
Emodin (Frangula emodin) is a naturally occurring anthraquinone present in the roots and barks of numerous plants; exerts antiproliferative effects in Y cells th...
CKI-7
T19913
CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ...
SR-3029
T3972
SR-3029 is a potent and highly specific CK1δ/CK1ε inhibitor.
Epiblastin A
T8987
Epiblastin A is an inhibitor of Casein Kinase 1 (CK1). Epiblastin A engages CK1 isoenzymes in cell lysate and induces efficient conversion of epiblast stem cells...
LH846
T1877
LH846 is a selective inhibitor of CK1δ (IC50 values are 290 nM, 1.3 uM and 2.5 uM for CK1δ, ε and α); exhibits no inhibitory activity at CK2.
A-443654
T14072
A-443654 is a pan-Akt inhibitor. A-443654 has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
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TargetMol