Casein Kinase

The Casein kinase 1 family of protein kinases are serine/threonine-selective enzymes that function as regulators of signal transduction pathways in most eukaryotic cell types. CK1 isoforms are involved in Wnt signaling, circadian rhythms, nucleo-cytoplasmic shuttling of transcription factors, DNA repair, and DNA transcription.

Cat. No.	Product name	CAS No.	Purity
T6315	MLN8054	869363-13-3	99.05%
T6315	MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.
T77500	Casein kinase 1δ-IN-6	1579991-01-7	99%
T77500	Casein kinase 1δ-IN-6 is a potent and selective inhibitor of the protein kinase CK-1δ with an IC50 of 23 nM.Casein kinase 1δ-IN-6 shows neuroprotective and anti-...
T10827	CK2/ERK8-IN-1	1085822-09-8	98.82%
T10827	CK2/ERK8-IN-1 (TMCB) is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds t...
T10687	Casein Kinase II Inhibitor IV	863598-09-8	98.81%
T10687	Casein Kinase II Inhibitor IV is an inducer of epidermal keratinocyte differentiation.
T5393	CK1-IN-1	1784751-20-7	98.79%
T5393	CK1-IN-1 (PUN51207) is a casein kinase 1 (CK1) inhibitor. CK1-IN-1 has IC50s of 15 nM, 16 nM, 73 nM for CK1δ, and CK1ε, p38σ MAPK, respectively.
T60005	CK1-IN-3	349438-74-0	98.70%
T60005	CK1-IN-3 is casein kinase 1 (CK1) inhibitor and can be used for research on the treatment or prevention of diseases associated with circadiantiazol rhythm, infla...
T13004	SSTC3	1242422-09-8	98.65%
T13004	SSTC3 is a casein kinase 1α (CK1α) activator with a Kd of 32 nM.SSTC3 has potential antitumor activity, inhibits WNT signaling, and suppresses SHH medulloblastom...
T77708	Casein kinase 1δ-IN-7	764694-25-9	98.6%
T77708	Casein kinase 1δ-IN-7 is a Casein kinase 1δ inhibitor for neurodegenerative diseases such as Alzheimer's disease.
T12237	NMS-P715	1202055-32-0	98.41%
T12237	NMS-P715 is a selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).
T5056	PF-4800567	1188296-52-7	98.23%
T5056	PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ.
T7949	NCC007	2342583-66-6	98.11%
T7949	NCC007 is a novel CKIα and CKIδ dual inhibitors by structural modification of N9 and C2 position of longdaysin.
T73269	CK2α-IN-1	443747-52-2	98%
T73269	CK2α-IN-1 is a selective non-ATP-competitive CK2α inhibitor with an IC50 of 7.0 µM and a Ki of 1.6 µM.CK2α-IN-1 exhibits potential anticancer activity and can be...
T1828	TTP 22	329907-28-0	97.78%
T1828	TTP 22 is a high affinity, ATP-competitive casein kinase 2 (CK2) inhibitor with IC50/Ki of 0.1 uM/40 nM, and shows selectivity >250-fold for CK2 over JNK3, ROCK1...
T10547	BioE-1115	1268863-35-9	97.38%
T10547	BioE-1115 is a selective and potent inhibitor of serine-threonine protein kinase (PASK, IC50 = 4 nM). BioE-1115 is a potent inhibitor of CK2α (IC50 = 10 μM).
T2869	Emodin	518-82-1	94.4%
T2869	Emodin (Frangula emodin) is a naturally occurring anthraquinone present in the roots and barks of numerous plants; exerts antiproliferative effects in Y cells th...
T19913	CKI-7	1177141-67-1	100.00%
T19913	CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ...
T3972	SR-3029	1454585-06-8	100%
T3972	SR-3029 is a potent and highly specific CK1δ/CK1ε inhibitor.
T8987	Epiblastin A	16470-02-3	100%
T8987	Epiblastin A is an inhibitor of Casein Kinase 1 (CK1). Epiblastin A engages CK1 isoenzymes in cell lysate and induces efficient conversion of epiblast stem cells...
T1877	LH846	639052-78-1
T1877	LH846 is a selective inhibitor of CK1δ (IC50 values are 290 nM, 1.3 uM and 2.5 uM for CK1δ, ε and α); exhibits no inhibitory activity at CK2.
T14072	A-443654	552325-16-3
T14072	A-443654 is a pan-Akt inhibitor. A-443654 has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).