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Cannabinoid Receptor

Cannabinoid receptors are of a class of cell membrane receptors in the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cannabinoid receptors contain seven transmembrane spanning domains. Cannabinoid receptors are activated by three major groups of ligands: endocannabinoids, produced by the mammillary body;[citation needed] plant cannabinoids (such as cannabidiol, produced by the cannabis plant); and synthetic cannabinoids (such as HU-210). All of the endocannabinoids and phytocannabinoids (plant based cannabinoids) are lipophilic, such as fat soluble compounds.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T13803 N-Oleoyl glycine 2601-90-3 99.92%
N-Oleoyl glycine
N-Oleoyl Glycine, a Lipoamino Acid, Stimulates Adipogenesis Associated With Activation of CB1 Receptor and Akt Signaling Pathway in 3T3-L1 Adipocyte
T21450 AM-2232 335161-19-8 99.89%
AM-2232
AM-2232 (UNII-40KCH8YIKP) is a potent and unselective agonist of the cannabinoid receptors.
T6527 GW842166X 666260-75-9 99.88%
GW842166X
GW842166X is a potent and highly selective agonist of cannabinoid receptor CB2 receptor with EC50 of 63 nM, shows no significant activity at CB1 receptor. Phase ...
TP1939L1 RVD-Hpα acetate(1193362-76-3 free base) TP1939L1 99.87%
RVD-Hpα acetate(1193362-76-3 free base)
RVD-Hpα acetate is the N-terminally extended form of human hemopressin that acts as a selective CB1 receptor agonist. Increases intracellular Ca2+ levels in cell...
T39024 PrNMI 1541244-33-0 99.87%
PrNMI
PrNMI is a highly effective and orally active agonist targeting the peripherally restricted cannabinoid 1 receptor (CB1R). It exhibits pronounced analgesic prope...
TP1900L1 Hemopressin (human, mouse) acetate TP1900L1 99.86%
Hemopressin (human, mouse) acetate
Hemopressin (human, mouse) acetate is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin is or...
T14204 6-Iodopravadoline 164178-33-0 99.86%
6-Iodopravadoline
6-Iodopravadoline (AM630) is an antagonist of CB2 (Ki: 31.2 nM). And it shows 165-fold selectivity more than CB1 receptors.
T41350 6-Bromopravadoline 166599-63-9 99.84%
6-Bromopravadoline
6-Bromopravadoline (WIN 54461) (WIN 54461) is an antagonist of CB1. 6-Bromopravadoline acts as an inhibitor of the binding of [3H]Win 55212-2 (IC 50 =515 nM) ref...
T4654 (±)-Ibipinabant 362519-49-1 99.83%
(±)-Ibipinabant
(±)-Ibipinabant ((±)-SLV319) has been used in trials studying the treatment of Obesity and Obesity and Type 2 Diabetes.
T7705 GW 405833 180002-83-9 99.82%
GW 405833
GW 405833 (L-768242) is an agonist of cannabinoid-2 (CB(2)) receptor-selective
T21861 Drinabant 358970-97-5 99.8%
Drinabant
Drinabant (AVE-1625) is an orally active CB1 receptor antagonist. Drinabant inhibits the agonist-stimulated calcium signal with IC50 values of 25 nM and 10 nM fo...
T22103 ML-193 713121-80-3 99.79%
ML-193
ML-193 (CID 1261822) is a potent and selective GPR55 antagonist( IC50 : 221 nM). It shows more than 27-fold selectivity for GPR55 over GPR35, CB1 and CB2, and ca...
T33452 ML192 460331-61-7 99.79%
ML192
ML192 (CID1434953) is a selective GPR55 ligand antagonist. ML192 is an inhibitor that inhibits β-arrestin transport, ERK1/2 phosphorylation, and PKCβII transloca...
TC0019 Pregnenolone acetate 1778-02-5 99.78%
Pregnenolone acetate
Pregnenolone acetate is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. It acts as a signaling-specific inhibi...
T3736 Olivetol 500-66-3 99.74%
Olivetol
Olivetol (5-n-Amylresorcinol) (5-pentylresorcinol, 5-pentyl-1,3-benzenediol) is an organic compound found in certain species of lichen; it is also a precursor in...
T22114 NESS 0327 494844-07-4 99.74%
NESS 0327
NESS 0327 is a high selectivity antagonist of the cannabinoid CB1 receptor. NESS 0327 is more than 60,000-fold selective for the CB1 receptor.
T12306 OMDM-5 616884-66-3 99.72%
OMDM-5
OMDM-5 is a selective anandamide cellular uptake (ACU)inhibitor(Ki of 4.8 μM).
T16928 SR144528 192703-06-3 99.6%
SR144528
SR144528 is an antagonist of the CB2 receptor (Ki = 0.6 nM) and inhibits microsomal ACAT activity (IC50 = 3.6 μM).
T4478 CID 16020046 834903-43-4 99.59%
CID 16020046
CID 16020046 (C390-0219) is a selective GPR55 antagonist, inhibiting GPR55 constitutive activity with IC50 of 0.15 μM in yeast.
T36520 COR659 544450-68-2 99.56%
COR659
COR659 is a GABAB positive allosteric modulator (PAM) . COR659 suppresses alcohol and chocolate self-administration in rats[1]. COR659 apparently exerts its effe...
N-Oleoyl glycine
T13803
N-Oleoyl Glycine, a Lipoamino Acid, Stimulates Adipogenesis Associated With Activation of CB1 Receptor and Akt Signaling Pathway in 3T3-L1 Adipocyte
AM-2232
T21450
AM-2232 (UNII-40KCH8YIKP) is a potent and unselective agonist of the cannabinoid receptors.
GW842166X
T6527
GW842166X is a potent and highly selective agonist of cannabinoid receptor CB2 receptor with EC50 of 63 nM, shows no significant activity at CB1 receptor. Phase ...
RVD-Hpα acetate(1193362-76-3 free base)
TP1939L1
RVD-Hpα acetate is the N-terminally extended form of human hemopressin that acts as a selective CB1 receptor agonist. Increases intracellular Ca2+ levels in cell...
PrNMI
T39024
PrNMI is a highly effective and orally active agonist targeting the peripherally restricted cannabinoid 1 receptor (CB1R). It exhibits pronounced analgesic prope...
Hemopressin (human, mouse) acetate
TP1900L1
Hemopressin (human, mouse) acetate is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin is or...
6-Iodopravadoline
T14204
6-Iodopravadoline (AM630) is an antagonist of CB2 (Ki: 31.2 nM). And it shows 165-fold selectivity more than CB1 receptors.
6-Bromopravadoline
T41350
6-Bromopravadoline (WIN 54461) (WIN 54461) is an antagonist of CB1. 6-Bromopravadoline acts as an inhibitor of the binding of [3H]Win 55212-2 (IC 50 =515 nM) ref...
(±)-Ibipinabant
T4654
(±)-Ibipinabant ((±)-SLV319) has been used in trials studying the treatment of Obesity and Obesity and Type 2 Diabetes.
GW 405833
T7705
GW 405833 (L-768242) is an agonist of cannabinoid-2 (CB(2)) receptor-selective
Drinabant
T21861
Drinabant (AVE-1625) is an orally active CB1 receptor antagonist. Drinabant inhibits the agonist-stimulated calcium signal with IC50 values of 25 nM and 10 nM fo...
ML-193
T22103
ML-193 (CID 1261822) is a potent and selective GPR55 antagonist( IC50 : 221 nM). It shows more than 27-fold selectivity for GPR55 over GPR35, CB1 and CB2, and ca...
ML192
T33452
ML192 (CID1434953) is a selective GPR55 ligand antagonist. ML192 is an inhibitor that inhibits β-arrestin transport, ERK1/2 phosphorylation, and PKCβII transloca...
Pregnenolone acetate
TC0019
Pregnenolone acetate is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. It acts as a signaling-specific inhibi...
Olivetol
T3736
Olivetol (5-n-Amylresorcinol) (5-pentylresorcinol, 5-pentyl-1,3-benzenediol) is an organic compound found in certain species of lichen; it is also a precursor in...
NESS 0327
T22114
NESS 0327 is a high selectivity antagonist of the cannabinoid CB1 receptor. NESS 0327 is more than 60,000-fold selective for the CB1 receptor.
OMDM-5
T12306
OMDM-5 is a selective anandamide cellular uptake (ACU)inhibitor(Ki of 4.8 μM).
SR144528
T16928
SR144528 is an antagonist of the CB2 receptor (Ki = 0.6 nM) and inhibits microsomal ACAT activity (IC50 = 3.6 μM).
CID 16020046
T4478
CID 16020046 (C390-0219) is a selective GPR55 antagonist, inhibiting GPR55 constitutive activity with IC50 of 0.15 μM in yeast.
COR659
T36520
COR659 is a GABAB positive allosteric modulator (PAM) . COR659 suppresses alcohol and chocolate self-administration in rats[1]. COR659 apparently exerts its effe...
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TargetMol