COX

Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme (specifically, a family of isozymes) that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin, from arachidonic acid. A member of the animal-type heme peroxidase family, it is also known as prostaglandin G/H synthase.

Cat. No.	Product name	CAS No.	Purity
TN3070	4beta-Hydroxywithanolide E	54334-04-2	98%
TN3070	4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progr...
TN3366	Ailanthoidol	156398-61-7	98%
TN3366	Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potentia...
TN1562	Dehydromiltirone	116064-77-8	98%
TN1562	Dehydromiltirone has antioxidant activity, it shows significant anti-neuroinflammatory effects through inhibiting PI3K/Akt phosphorylation and then inhibiting NF...
TN1715	Guaiacin	36531-08-5	98%
TN1715	(+)-Guaiacin has significant neuroprotective, and anti-inflammatory activities, it can inhibit cyclooxygenase (COX)-1 and COX-2.
T16464	Pelubiprofen	69956-77-0	98%
T16464	Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway. It also has significant anti-inflammatory ...
TN4463	Lupeolic acid	87355-32-6	98%
TN4463	Lupeolic acid has anti-inflammatory activity.
TN4879	Questinol	35688-09-6	98%
TN4879	Questinol exhibits significant anti-obesity activity. It shows anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, it can inhibit th...
T11761	Tarlox-TKI	2135696-72-7	98%
T11761	Kinase inhibitor-1 is a kinase inhibitor.
TN1755	Hyperforin	11079-53-1	98%
TN1755	Hyperforin acts as an angiogenesis inhibitor, it as a possible antidepressant component of hypericum extracts.
T12419	PF-04634817 succinate	2140301-98-8	98%
T12419	PF-0463481 succinate is a potent and orally active dual antagonist of CCR2/CCR5 with comparable human and rodent CCR2 potency with IC50 of 20.8 nM.
T15449	GW-406381	221148-46-5	98%
T15449	GW406381 is a highly selective inhibitor of cyclooxygenase-2 (COX-2). GW406381 also attenuates spontaneous ectopic discharge in the sural nerves of rats followin...
TN3806	Dehydroglyasperin C	199331-35-6	98%
TN3806	Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemop...
TN1143	1-O-Acetyl britannilactone	681457-46-5	98%
TN1143	1-O-Acetyl britannilactone shows antifungal, and anti-cancer activities, it suppresses angiogenesis and lung cancer cell growth possibly via regulating the VEGFR...
TMA1122	N-Feruloylserotonin	68573-23-9	98%
TMA1122	Moschamine is a very potent compound that is able to inhibit COX-I by 58% and COX-II by 54%, at the concentration of 0.1 μmol L⁻1, it may suppress cAMP for...
TMA1570	Sappanone A	102067-84-5	98%
TMA1570	Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2 ...
TN1062	Peonidin chloride	134-01-0	98%
TN1062	Peonidin chloride has antioxidant activity. Peonidin has show potent inhibitory and apoptotic effects on cancer cells in vitro, notably metastatic human breast c...
T11169	Eicosatetraynoic acid	1191-85-1	98%
T11169	Eicosatetraynoic acid (ETYA) activates PPARα and PPARγ chimeras at 10 μM. Eicosatetraynoic acid (ETYA) is a nonspecific inhibitor of cyclooxygenase and lipoxygen...
T19679	Benoxaprofen	51234-28-7	98%
T19679	Benoxaprofen is a non-steroidal anti-inflammatory drug.
TN4583	Moringin	73255-40-0	98%
TN4583	Moringin is an isothiocyanate obtained from myrosinase-mediated hydrolysis of the glucosinolate precursor glucoMoringin present in Moringa oleifera seeds. Moring...
T16169	N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride	4272-74-6	98%
T16169	N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride is an inhibitor of trypsin-like protease. N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride exhib...