CCR

CC chemokine receptors (or beta chemokine receptors) are integral membrane proteins that specifically bind and respond to cytokines of the CC chemokine family. They represent one subfamily of chemokine receptors, a large family of G protein-linked receptors that are known as seven transmembrane (7-TM) proteins since they span the cell membrane seven times. To date, ten true members of the CC chemokine receptor subfamily have been described. These are named CCR1 to CCR10 according to the IUIS/WHO Subcommittee on Chemokine Nomenclature.

Cat. No.	Product name	CAS No.	Purity
T23321	SB 328437	247580-43-4	99.11%
T23321	SB 328437 is an effective and selective antagonist of CCR3 (IC50 = 4.5 nM).
T17225	Vercirnon	698394-73-9	99.15%
T17225	Vercirnon is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.
TQ0283	RS102895	300815-41-2	99.54%
TQ0283	RS102895 is a potent CCR2 antagonist (IC50: 360 nM) and shows no effect on CCR1.
T6016	Maraviroc	376348-65-1	99.55%
T6016	Maraviroc is a C-C Chemokine Receptor Type 5 (CCR5) antagonist, and for MIP-1α(IC50=3.3 nM), MIP-1β (IC50=7.2 nM) and RANTES(IC50=5.2 nM).Maraviroc inhibits HIV-...
T7499	TAK-779	229005-80-5	99.58%
T7499	TAK-779 is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).
TN1273	7,4'-Dihydroxyflavone	2196-14-7	99.6%
TN1273	4',7-Dihydroxyflavone can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2.
T14900	CCR2-RA-[R]	512177-83-2	99.65%
T14900	CCR2-RA-[R] is a C-C chemokine receptor type 2 (CCR2) allosteric antagonist (IC50: 103 nM).
T4674	SB297006	58816-69-6	99.65%
T4674	SB 297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ....
T12773	RS102895 hydrochloride	1173022-16-6	99.7%
T12773	RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM).
T21870	C-021	864289-85-0	99.74%
T21870	C 021 dihydrochloride is a potent CCR4 antagonist. C-021 dihydrochloride potently inhibits functional chemotaxis in humans and mice with IC50s of 140 nM and 39 n...
T3327	Artemotil	75887-54-6	99.76%
T3327	Arteether is a new, fast-acting antimalarial drug.
T4584	BMS-813160	1286279-29-5	99.78%
T4584	BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular.
T11481	GSK2239633A	1240516-71-5	99.78%
T11481	GSK2239633A is an allosteric antagonist of CC-chemokine receptor 4 (CCR4) with a pIC50 of 7.96 for the binding of [125I]-TARC to human CCR4.
T60145	CCR6 antagonist 1	588674-64-0	99.89%
T60145	CCR6 antagonist 1 is a CCR6 antagonist. CCR6 antagonist 1 inhibits the CCL20/CCR6 axis. CCR6 antagonist 1 can be used in the research of autoimmune-mediated infl...
T3430	PF-4136309	1341224-83-6	99.9%
T3430	INCB8761(PF-4136309) is a specific, effective, and orally bioavailable CCR2 antagonist.
T3188	NSC5844	140926-75-6	99.91%
T3188	NSC5844 (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic activities.
T16111	ML604086	850330-18-6	99.91%
T16111	ML604086 suppresses CCL1 mediated chemotaxis and enhances intracellular Ca2 concentrations. ML604086 is a selective inhibitor of CCR8. It also inhibiting CCL1 bi...
T4300	AZD2098	566203-88-1	99.92%
T4300	AZD2098 is a potent CC-chemokine receptor 4 (CCR4) inhibitor used for asthma research.
T2375	BX471	217645-70-0	99.94%
T2375	BX471 is a potent, selective non-peptide CCR1 antagonist.
T14909	CCX140	1100318-47-5	99.95%
T14909	CCX140 (CCX140-B) is an antagonist of CCR2.