CCR

CC chemokine receptors (or beta chemokine receptors) are integral membrane proteins that specifically bind and respond to cytokines of the CC chemokine family. They represent one subfamily of chemokine receptors, a large family of G protein-linked receptors that are known as seven transmembrane (7-TM) proteins since they span the cell membrane seven times. To date, ten true members of the CC chemokine receptor subfamily have been described. These are named CCR1 to CCR10 according to the IUIS/WHO Subcommittee on Chemokine Nomenclature.

Cat. No.	Product name	CAS No.	Purity
T3360	ZK 756326	874911-96-3	99.06%
T3360	ZK 756326 is a selective, non-peptide CCR8 chemokine receptor agonist (IC50: 1.8 μM, in human; 2.6 μM, in mouse). Displays no activity at CCR4/5 and CXCR3/4 and ...
T26861	BMS-817399	1202400-18-7	99.05%
T26861	BMS-817399 is an orally active antagonist of CCR1 with IC50s of binding affinity and chemotaxis inhibition potencies and can be used in studies about rheumatoid ...
TQ0297	Cenicriviroc	497223-25-3	98.98%
TQ0297	Cenicriviroc (TAK-652) is an orally active, dual antagonist of CCR2/CCR5. It also inhibits both HIV-1 and HIV-2, and displays potent anti-infective and anti-infl...
T10715	CCR6 inhibitor 1	2437547-04-9	98.91%
T10715	CCR6 inhibitor 1 is an effective and selective inhibitor of CCR6 (IC50 of monkey and human CCR6 was 0.45 nM and 6 nM, respectively). CCR6 is associated with both...
T27682	CCR2 antagonist 5	1228650-83-6	98.79%
T27682	CCR2 antagonist 5 (JNJ-41443532) is a selective and orally active hCCR2 inhibitor with good binding affinity (IC50=37 nM) and potent functional antagonism (chemo...
T16091	MK-0812 Succinate	851916-42-2	98.62%
T16091	MK-0812 Succinate is an effective and selective CCR2 antagonist. It also has a high affinity at CCR2.
T28072L	MLN-3897 TFA		98.62%
T28072L	MLN-3897 TFA is a potent CCR1 antagonist that inhibits the binding of 125I-MIP-1α to THP-1 cell membranes.
T10639	C-021 dihydrochloride	1784252-84-1	98.51%
T10639	C-021 dihydrochloride is a potent CCR4 antagonist. It potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM.
T6413	Bindarit	130641-38-2	98.48%
T6413	Bindarit (AF2838) displays specific inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.
T10708	CCR1 antagonist 6	2436773-01-0	98.40%
T10708	CCR1 antagonist 6 is a CCR1 antagonist (IC50: 3 nM).
T10425	AZ084	929300-19-6	98.34%
T10425	AZ084 is a potent, selective, allosteric, and oral active CCR8 antagonist (Ki: 0.9 nM). It has the potential to treat asthma.
TQ0103	INCB3344	1262238-11-8	98.2%
TQ0103	INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8 nM...
T24700	R243	688352-84-3	97.86%
T24700	R243 is CCR8 signaling and chemotaxis inhibitor.
T14909	CCX140	1100318-47-5	97.58%
T14909	CCX140 (CCX140-B) (CCX140-B) is an antagonist of CCR2.
T9983	CCR8 antagonist 1	723304-76-5	97.33%
T9983	CCR8 antagonist 1 is an antagonist of C-C Motif Chemokine Receptor 8 (CCR8) with a Ki value of 1.6 nM.
T3435	Vicriviroc maleate	599179-03-0	97.27%
T3435	Vicriviroc maleate (SCH-417690 (maleate))(Sch-417690) is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus. The IC50...
T30260	AZD-5672	780750-65-4	95.58%
T30260	AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM. AZD-5672 inhibits hERG cardiac ion channel binding and P-gp-mediated digoxin transport with IC50s of 7...
T21870	C-021	864289-85-0	100.00%
T21870	C 021 dihydrochloride is a potent CCR4 antagonist. C-021 (4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-) dihydrochloride potently in...
T10712	CCR2 antagonist 3	1380100-86-6	100%
T10712	CCR2 antagonist 3 (AZD-2927) is an antagonist of CCR2.
T7624	DAPTA	106362-34-9	100%
T7624	DAPTA (Adaptavir) is an inhibitor of CCR5, shows potent anti-HIV activities.