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Beta Amyloid

Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. The peptides derive from the amyloid precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ. Aβ molecules can aggregate to form flexible soluble oligomers which may exist in several forms. It is now believed that certain misfolded oligomers (known as "seeds") can induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T7527 Frentizole 26130-02-9 98%
Frentizole
Frentizole, an immunosuppressive agent, is an inhibitor of the Aβ-ABAD interaction
T8012 Scyllo-Inositol 488-59-5 98%
Scyllo-Inositol
Scyllo-Inositol (Scyllitol) is one of the inositol stereoisomers, rare in the nature, and expected as a promising disease-modifying therapeutic agent for Alzheim...
T21825 TAE-1 1414469-59-2 98%
TAE-1
TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. It inhibits cholinesterases AChE and BuChE with IC50 of 0.3 μM and 3.9 μM, respectively.
T2262 Itanapraced 749269-83-8 98%
Itanapraced
Itanapraced (CHF5074), a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM).
T7490 ARN2966 102212-26-0 98%
ARN2966
ARN2966 is an inhibitor of amyloid precursor protein (APP)and amyloid-β (Aβ) secretion.
T14284 β-Amyloid (25-35) 131602-53-4 97.91%
β-Amyloid (25-35)
β-Amyloid (25-35) (Aβ25-35) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide. Which has shown neurotoxic activities in cultured cells.
T7566L1 GRGDSPK acetate 144027-77-0 97.9%
GRGDSPK acetate
GRGDSPK acetate shows inhibitory activity against integrin-fibronectin binding and can be used in research on integrins in bone formation and resorption.
T6274 RO4929097 847925-91-1 97.68%
RO4929097
RO4929097 (RG-4733), a γ secretase inhibitor (IC50: 4 nM), inhibits cellular processing of Aβ40 and Notch (EC50: 14/5 nM).
TN6919 Methyl tridecanoate 1731-88-0 97.63%
Methyl tridecanoate
Methyl tridecanoate is a natural product.
T19892 BSBM7 6968-11-2 97.27%
BSBM7
BSBM7 is an inhibitor of Aβ aggregation and neuronal toxicity.
T22417 Rutin hydrate 190836-14-7 97.23%
Rutin hydrate
Rutin hydrate (Sophorin), a kind of glycoside, widely exists in many plants including citrus fruit.
TP1786L Amyloid β-Protein 10-20 acetate TP1786L 97.23%
Amyloid β-Protein 10-20 acetate
Amyloid β-Protein 10-20 acetate (Amyloid β-Protein 10-20 acetate (152286-31-2 free base)) is a fragment of Amyloid-β peptide, maybe used in the research of neuro...
T1686 Hematoxylin 517-28-2 97.09%
Hematoxylin
Hematoxylin (Natural Black 1) is a dye obtained from the heartwood of logwood (Haematoxylon campechianum Linn., Leguminosae) used as a stain in microscopy and in...
T2507 Azeliragon 603148-36-3 96.7%
Azeliragon
Azeliragon (TTP488) is an antagonist at the Receptor for Advanced Glycation End products; is evaluated as a potential treatment for patients with mild-to-moderat...
TP1856 Colivelin 867021-83-8 96.56%
Colivelin
Colivelin is a neuroprotective peptide and activator of STAT3. Colivelin is a hybrid peptide synthesized to enhance the neuroprotective effects of humanin (HN).
TN1027 β-Amyrin 559-70-6 96.49%
β-Amyrin
β-Amyrin (beta-Amyrin) has antiviral, hepatoprotective, antinociceptive, anti-inflammatory
TP1359L Amyloid β Peptide (42-1)(human) acetate 95.20%
Amyloid β Peptide (42-1)(human) acetate
Amyloid β Peptide (42-1)(human) acetate is the inactive form of Amyloid β Peptide (1-42). Amyloid β Peptide (42-1)(human) acetate is a 42-amino acid peptide whic...
T28441 PPI-1019 290828-45-4 95.16%
PPI-1019
PPI-1019 is an APP (β-amyloid A4) inhibitor for the treatment of neurological disorders and the study of Alzheimer's disease (AD).
T14673 BMS 299897 290315-45-6 100%
BMS 299897
BMS 299897 is a sulfonamide γ-secretase inhibitor. It has an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor pr...
TP1866L β-amyloid 1-11 acetate(190436-05-6 free base) TP1866L 100%
β-amyloid 1-11 acetate(190436-05-6 free base)
β-amyloid 1-11 acetate is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.
Frentizole
T7527
Frentizole, an immunosuppressive agent, is an inhibitor of the Aβ-ABAD interaction
Scyllo-Inositol
T8012
Scyllo-Inositol (Scyllitol) is one of the inositol stereoisomers, rare in the nature, and expected as a promising disease-modifying therapeutic agent for Alzheim...
TAE-1
T21825
TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. It inhibits cholinesterases AChE and BuChE with IC50 of 0.3 μM and 3.9 μM, respectively.
Itanapraced
T2262
Itanapraced (CHF5074), a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM).
ARN2966
T7490
ARN2966 is an inhibitor of amyloid precursor protein (APP)and amyloid-β (Aβ) secretion.
β-Amyloid (25-35)
T14284
β-Amyloid (25-35) (Aβ25-35) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide. Which has shown neurotoxic activities in cultured cells.
GRGDSPK acetate
T7566L1
GRGDSPK acetate shows inhibitory activity against integrin-fibronectin binding and can be used in research on integrins in bone formation and resorption.
RO4929097
T6274
RO4929097 (RG-4733), a γ secretase inhibitor (IC50: 4 nM), inhibits cellular processing of Aβ40 and Notch (EC50: 14/5 nM).
Methyl tridecanoate
TN6919
Methyl tridecanoate is a natural product.
BSBM7
T19892
BSBM7 is an inhibitor of Aβ aggregation and neuronal toxicity.
Rutin hydrate
T22417
Rutin hydrate (Sophorin), a kind of glycoside, widely exists in many plants including citrus fruit.
Amyloid β-Protein 10-20 acetate
TP1786L
Amyloid β-Protein 10-20 acetate (Amyloid β-Protein 10-20 acetate (152286-31-2 free base)) is a fragment of Amyloid-β peptide, maybe used in the research of neuro...
Hematoxylin
T1686
Hematoxylin (Natural Black 1) is a dye obtained from the heartwood of logwood (Haematoxylon campechianum Linn., Leguminosae) used as a stain in microscopy and in...
Azeliragon
T2507
Azeliragon (TTP488) is an antagonist at the Receptor for Advanced Glycation End products; is evaluated as a potential treatment for patients with mild-to-moderat...
Colivelin
TP1856
Colivelin is a neuroprotective peptide and activator of STAT3. Colivelin is a hybrid peptide synthesized to enhance the neuroprotective effects of humanin (HN).
β-Amyrin
TN1027
β-Amyrin (beta-Amyrin) has antiviral, hepatoprotective, antinociceptive, anti-inflammatory
Amyloid β Peptide (42-1)(human) acetate
TP1359L
Amyloid β Peptide (42-1)(human) acetate is the inactive form of Amyloid β Peptide (1-42). Amyloid β Peptide (42-1)(human) acetate is a 42-amino acid peptide whic...
PPI-1019
T28441
PPI-1019 is an APP (β-amyloid A4) inhibitor for the treatment of neurological disorders and the study of Alzheimer's disease (AD).
BMS 299897
T14673
BMS 299897 is a sulfonamide γ-secretase inhibitor. It has an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor pr...
β-amyloid 1-11 acetate(190436-05-6 free base)
TP1866L
β-amyloid 1-11 acetate is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.
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TargetMol