Beta Amyloid

Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. The peptides derive from the amyloid precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ. Aβ molecules can aggregate to form flexible soluble oligomers which may exist in several forms. It is now believed that certain misfolded oligomers (known as "seeds") can induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection.

Cat. No.	Product name	CAS No.	Purity
T10782	CGP52411	145915-58-8	98%
T10782	CGP52411 is an orally active, and ATP-competitive inhibitor of EGFR (IC50: 0.3 μM). CGP52411 blocks the toxic influx of Ca2+ ions into neuronal cells and dramati...
T63540	Astrophloxine	14696-39-0	98%
T63540	Astrophloxine is a fluorescent imaging probe that targets antiparallel dimers.Astrophloxine can be used to detect aggregated Aβ in brain tissue and cerebrospinal...
T4077	PE859	1402727-29-0	98%
T4077	PE859 is a potent inhibitor of both tau and Aβ aggregation.
TP1214L	β-Amyloid 15-21 acetate	TP1214L	98%
TP1214L	β-amyloid (15-21) acetate is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease. This fragment is involved in beta sheet formati...
T1637	Deferoxamine Mesylate	138-14-7	98%
T1637	Deferoxamine is an iron-chelating agent that binds free iron in a stable complex. It also is an inhibitor of ferroptosis.
T11043	Dihydroergocristine mesylate	24730-10-7	98%
T11043	Dihydroergocristine mesylate(DHEC mesylate) is the methanesulfonic acid salt of dihydroergocristine. It has been used as the for the symptomatic treatment of men...
T2961	Notoginsenoside R1	80418-24-2	98%
T2961	Notoginsenoside R1 has been shown to exhibit antioxidant, antiapoptotic, anti-inflammatory, and immune-stimulatory properties.
T2777	Ginsenoside Rg1	22427-39-0	98%
T2777	Ginsenosides are a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng). It improves spatial learning and in...
T3394	Timosaponin BII	136656-07-0	98%
T3394	Timosaponin BII has anti-dementia activity and may be useful for the treatment of type 2 diabetes. Timosaponin BII has antioxidant activity, can inhibit the up-r...
T2873	Ginsenoside Rg2	52286-74-5	98%
T2873	Ginsenoside Rg2 is one of the major active components of ginseng, act as an NF-κB inhibitor.
T6495	EUK-134	81065-76-1	98%
T6495	EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amy...
TN1725	Hederacolchiside E	33783-82-3	98%
TN1725	Hederacolchiside E has antioxidant activity and shows neuroprotective effects in Alzheimer's disease (AD) models via modulating oxidative stress. Hederacolchisid...
T21470L	Davunetide acetate		98%
T21470L	Davunetide acetate is derived from activity-dependent neuroprotective protein existing in the mammalian CNS. Davunetide acetate is a microtubule-stabilizing pept...
T2262	Itanapraced	749269-83-8	98%
T2262	CHF5074, a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM).
T6202	DAPT	208255-80-5	98%
T6202	DAPT is a novel γ-secretase inhibitor which reduces the Aβ production (IC50: 20 nM in HEK 293 cells) and Aβ42 levels (IC50: 200 nM).
T37621	Ezeprogind disulfate	1616671-13-6	98%
T37621	Ezeprogind disulfate is a neurotrophic inducer. Ezeprogind disulfate targets all causes of neurodegeneration including Abeta protein or tau protein. Ezeprogind d...
T8012	Scyllo-Inositol	488-59-5	98%
T8012	Scyllo-Inositol is one of the inositol stereoisomers, rare in the nature, and expected as a promising disease-modifying therapeutic agent for Alzheimer's disease...
T6708	Tolcapone	134308-13-7	98%
T6708	Tolcapone is a catechol-O-methyltransferase inhibitor used in the therapy of Parkinson disease as adjunctive therapy in combination with levodopa and carbidopa.
T4S0350	Licochalcone B	58749-23-8	98%
T4S0350	1. Licochalcone B (LCB) inhibits the proliferation of human malignant bladder cancer cell lines (T24 and EJ) in vitro and antitumor activity in vivo in MB49 (mur...
T4398	LX2343	333745-53-2	98%
T4398	LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343...