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Beta Amyloid

Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. The peptides derive from the amyloid precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ. Aβ molecules can aggregate to form flexible soluble oligomers which may exist in several forms. It is now believed that certain misfolded oligomers (known as "seeds") can induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection.
Cat. No. Product name CAS No. Purity Chemical Structure
T10782 CGP52411 145915-58-8 98%
CGP52411 is an orally active, and ATP-competitive inhibitor of EGFR (IC50: 0.3 μM). CGP52411 blocks the toxic influx of Ca2+ ions into neuronal cells and dramati...
T63540 Astrophloxine 14696-39-0 98%
Astrophloxine is a fluorescent imaging probe that targets antiparallel dimers.Astrophloxine can be used to detect aggregated Aβ in brain tissue and cerebrospinal...
T4077 PE859 1402727-29-0 98%
PE859 is a potent inhibitor of both tau and Aβ aggregation.
TP1214L β-Amyloid 15-21 acetate TP1214L 98%
β-amyloid (15-21) acetate is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease. This fragment is involved in beta sheet formati...
T1637 Deferoxamine Mesylate 138-14-7 98%
Deferoxamine is an iron-chelating agent that binds free iron in a stable complex. It also is an inhibitor of ferroptosis.
T11043 Dihydroergocristine mesylate 24730-10-7 98%
Dihydroergocristine mesylate(DHEC mesylate) is the methanesulfonic acid salt of dihydroergocristine. It has been used as the for the symptomatic treatment of men...
T2961 Notoginsenoside R1 80418-24-2 98%
Notoginsenoside R1 has been shown to exhibit antioxidant, antiapoptotic, anti-inflammatory, and immune-stimulatory properties.
T2777 Ginsenoside Rg1 22427-39-0 98%
Ginsenosides are a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng). It improves spatial learning and in...
T3394 Timosaponin BII 136656-07-0 98%
Timosaponin BII has anti-dementia activity and may be useful for the treatment of type 2 diabetes. Timosaponin BII has antioxidant activity, can inhibit the up-r...
T2873 Ginsenoside Rg2 52286-74-5 98%
Ginsenoside Rg2 is one of the major active components of ginseng, act as an NF-κB inhibitor.
T6495 EUK-134 81065-76-1 98%
EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amy...
TN1725 Hederacolchiside E 33783-82-3 98%
Hederacolchiside E has antioxidant activity and shows neuroprotective effects in Alzheimer's disease (AD) models via modulating oxidative stress. Hederacolchisid...
T21470L Davunetide acetate 98%
Davunetide acetate is derived from activity-dependent neuroprotective protein existing in the mammalian CNS. Davunetide acetate is a microtubule-stabilizing pept...
T2262 Itanapraced 749269-83-8 98%
CHF5074, a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM).
T6202 DAPT 208255-80-5 98%
DAPT is a novel γ-secretase inhibitor which reduces the Aβ production (IC50: 20 nM in HEK 293 cells) and Aβ42 levels (IC50: 200 nM).
T37621 Ezeprogind disulfate 1616671-13-6 98%
Ezeprogind disulfate is a neurotrophic inducer. Ezeprogind disulfate targets all causes of neurodegeneration including Abeta protein or tau protein. Ezeprogind d...
T8012 Scyllo-Inositol 488-59-5 98%
Scyllo-Inositol is one of the inositol stereoisomers, rare in the nature, and expected as a promising disease-modifying therapeutic agent for Alzheimer's disease...
T6708 Tolcapone 134308-13-7 98%
Tolcapone is a catechol-O-methyltransferase inhibitor used in the therapy of Parkinson disease as adjunctive therapy in combination with levodopa and carbidopa.
T4S0350 Licochalcone B 58749-23-8 98%
1. Licochalcone B (LCB) inhibits the proliferation of human malignant bladder cancer cell lines (T24 and EJ) in vitro and antitumor activity in vivo in MB49 (mur...
T4398 LX2343 333745-53-2 98%
LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343...
CGP52411
T10782
CGP52411 is an orally active, and ATP-competitive inhibitor of EGFR (IC50: 0.3 μM). CGP52411 blocks the toxic influx of Ca2+ ions into neuronal cells and dramati...
Astrophloxine
T63540
Astrophloxine is a fluorescent imaging probe that targets antiparallel dimers.Astrophloxine can be used to detect aggregated Aβ in brain tissue and cerebrospinal...
PE859
T4077
PE859 is a potent inhibitor of both tau and Aβ aggregation.
β-Amyloid 15-21 acetate
TP1214L
β-amyloid (15-21) acetate is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease. This fragment is involved in beta sheet formati...
Deferoxamine Mesylate
T1637
Deferoxamine is an iron-chelating agent that binds free iron in a stable complex. It also is an inhibitor of ferroptosis.
Dihydroergocristine mesylate
T11043
Dihydroergocristine mesylate(DHEC mesylate) is the methanesulfonic acid salt of dihydroergocristine. It has been used as the for the symptomatic treatment of men...
Notoginsenoside R1
T2961
Notoginsenoside R1 has been shown to exhibit antioxidant, antiapoptotic, anti-inflammatory, and immune-stimulatory properties.
Ginsenoside Rg1
T2777
Ginsenosides are a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng). It improves spatial learning and in...
Timosaponin BII
T3394
Timosaponin BII has anti-dementia activity and may be useful for the treatment of type 2 diabetes. Timosaponin BII has antioxidant activity, can inhibit the up-r...
Ginsenoside Rg2
T2873
Ginsenoside Rg2 is one of the major active components of ginseng, act as an NF-κB inhibitor.
EUK-134
T6495
EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amy...
Hederacolchiside E
TN1725
Hederacolchiside E has antioxidant activity and shows neuroprotective effects in Alzheimer's disease (AD) models via modulating oxidative stress. Hederacolchisid...
Davunetide acetate
T21470L
Davunetide acetate is derived from activity-dependent neuroprotective protein existing in the mammalian CNS. Davunetide acetate is a microtubule-stabilizing pept...
Itanapraced
T2262
CHF5074, a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM).
DAPT
T6202
DAPT is a novel γ-secretase inhibitor which reduces the Aβ production (IC50: 20 nM in HEK 293 cells) and Aβ42 levels (IC50: 200 nM).
Ezeprogind disulfate
T37621
Ezeprogind disulfate is a neurotrophic inducer. Ezeprogind disulfate targets all causes of neurodegeneration including Abeta protein or tau protein. Ezeprogind d...
Scyllo-Inositol
T8012
Scyllo-Inositol is one of the inositol stereoisomers, rare in the nature, and expected as a promising disease-modifying therapeutic agent for Alzheimer's disease...
Tolcapone
T6708
Tolcapone is a catechol-O-methyltransferase inhibitor used in the therapy of Parkinson disease as adjunctive therapy in combination with levodopa and carbidopa.
Licochalcone B
T4S0350
1. Licochalcone B (LCB) inhibits the proliferation of human malignant bladder cancer cell lines (T24 and EJ) in vitro and antitumor activity in vivo in MB49 (mur...
LX2343
T4398
LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343...
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