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Beta Amyloid

Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. The peptides derive from the amyloid precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ. Aβ molecules can aggregate to form flexible soluble oligomers which may exist in several forms. It is now believed that certain misfolded oligomers (known as "seeds") can induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection.
Cat. No. Product name CAS No. Purity Chemical Structure
TN4635 Neoechinulin A 51551-29-2 98%
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the ...
TN3218 7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one 100667-52-5 98%
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may...
T19142 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine 566169-98-0 98%
4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM).
T10453 BACE1-IN-5 T10453 98%
BACE1-IN-5 (Compound 15) is a β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC 50 of 9.1 nM. BACE1-IN-5 also inhibits cellular amy...
T19013 Hoechst 34580 tetrahydrochloride T19013 98%
Hoechst 34580 tetrahydrochloride, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
TN4571 Mirabijalone D 485811-84-5 98%
Mirabijalone D is a non-competitive inhibitor based on the Dixon plot.It inhibits Aβ1-42 production by 43.7% in APPSW-N2a cells.
T6562 Latrepirdine dihydrochloride 97657-92-6 98%
Latrepirdine is an orally active, and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihi...
TN3618 Cedrin 75513-81-4 98%
Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative s...
TN4865 Putraflavone 23624-21-7 98%
Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.
TN1919 (+)-Medioresinol 40957-99-1 98%
Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in th...
TN3410 Anatabine 581-49-7 98%
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
T14673 BMS 299897 290315-45-6 98%
BMS 299897 is a sulfonamide γ-secretase inhibitor. It has an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor pr...
T14525 Begacestat 769169-27-9 98%
Begacestat is a selective thiophene sulfonamide amyloid precursor protein gamma-secretase inhibitor (Aβ40,IC50=15 nM),and for the treatment of Alzheimer's diseas...
T7566L1 GRGDSPK acetate 144027-77-0 98%
GRGDSPK acetate shows inhibitory activity against integrin-fibronectin binding and can be used in research on integrins in bone formation and resorption.
T22932L LPYFD-NH2 acetate 98%
LPYFD-NH2 acetate shows some inhibitory effect on the aggregation of Abeta(1-42).
TQ0026 MDR-1339 1018946-38-7 98%
MDR-1339 (DWK-1339) is an orally active and blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.
TP1935L1 RAGE antagonist peptide acetate TP1935L1 98%
RAGE antagonist peptide acetate is an advanced antagonist of glycation end products (RAGE). RAGE antagonist peptide acetate possesses anti-tumor and anti-inflamm...
TN1116 Schisandrone 98619-25-1 98%
Schisandrone has strong activities of anti-oxidation, effectively scavenges hydroxyl radical and superoxide anion, and has protective effects on cells under acti...
TN2211 Silybin B 142797-34-0 98%
Silybin B is an effective inhibitor of raloxifene 4 '- and 6-glucosalylation, an effective anti-fibrinogenic and anti-oligomeric component of Silymarin, with fre...
T5810 TABERSONINE HYDROCHLORIDE 29479-00-3 98%
TABERSONINE HYDROCHLORIDE is a natural product extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1 42) aggregation and toxicity.
Neoechinulin A
TN4635
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the ...
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one
TN3218
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may...
4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine
T19142
4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM).
BACE1-IN-5
T10453
BACE1-IN-5 (Compound 15) is a β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC 50 of 9.1 nM. BACE1-IN-5 also inhibits cellular amy...
Hoechst 34580 tetrahydrochloride
T19013
Hoechst 34580 tetrahydrochloride, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
Mirabijalone D
TN4571
Mirabijalone D is a non-competitive inhibitor based on the Dixon plot.It inhibits Aβ1-42 production by 43.7% in APPSW-N2a cells.
Latrepirdine dihydrochloride
T6562
Latrepirdine is an orally active, and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihi...
Cedrin
TN3618
Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative s...
Putraflavone
TN4865
Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.
(+)-Medioresinol
TN1919
Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in th...
Anatabine
TN3410
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
BMS 299897
T14673
BMS 299897 is a sulfonamide γ-secretase inhibitor. It has an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor pr...
Begacestat
T14525
Begacestat is a selective thiophene sulfonamide amyloid precursor protein gamma-secretase inhibitor (Aβ40,IC50=15 nM),and for the treatment of Alzheimer's diseas...
GRGDSPK acetate
T7566L1
GRGDSPK acetate shows inhibitory activity against integrin-fibronectin binding and can be used in research on integrins in bone formation and resorption.
LPYFD-NH2 acetate
T22932L
LPYFD-NH2 acetate shows some inhibitory effect on the aggregation of Abeta(1-42).
MDR-1339
TQ0026
MDR-1339 (DWK-1339) is an orally active and blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.
RAGE antagonist peptide acetate
TP1935L1
RAGE antagonist peptide acetate is an advanced antagonist of glycation end products (RAGE). RAGE antagonist peptide acetate possesses anti-tumor and anti-inflamm...
Schisandrone
TN1116
Schisandrone has strong activities of anti-oxidation, effectively scavenges hydroxyl radical and superoxide anion, and has protective effects on cells under acti...
Silybin B
TN2211
Silybin B is an effective inhibitor of raloxifene 4 '- and 6-glucosalylation, an effective anti-fibrinogenic and anti-oligomeric component of Silymarin, with fre...
TABERSONINE HYDROCHLORIDE
T5810
TABERSONINE HYDROCHLORIDE is a natural product extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1 42) aggregation and toxicity.
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