BTK

Bruton's tyrosine kinase (abbreviated Btk or BTK), also known as tyrosine-protein kinase BTK, is a tyrosine kinase that is encoded by the BTK gene in humans. BTK plays a crucial role in B cell development.

Cat. No.	Product name	CAS No.	Purity
T9706	BTK inhibitor 17	1858206-76-4	99.57%
BTK inhibitor 17 is a potent irreversible BTK inhibitor (IC50 = 2.1 nM). BTK inhibitor 17 can be used in rheumatoid arthritis studies.
T14323	ARQ 531	2095393-15-8	99.59%
ARQ-531 is a potent and orally active BTK inhibitor with potential antineoplastic activity, with IC50s of 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectiv...
T4391	Syk Inhibitor II (hydrochloride)	227449-73-2	99.59%
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chain...
T6078	Saracatinib	379231-04-6	99.63%
Saracatinib (AZD0530) is an effective Src inhibitor (IC50: 2.7 nM), and effective to Lck, Fyn, Lyn, Blk, Fgr and c-Yes.
T17098	Tilfrinib	1600515-49-8	99.73%
Tilfrinib is an effective and selective inhibitor of breast tumor kinase(Brk, IC50 = 3.15 nM) which displays anti-proliferative and anti-tumor activities.
T7584	Zanubrutinib	1691249-45-2	99.74%
Zanubrutinib is an inhibitor of Bruton tyrosine kinase (BTK).
T12542	Rilzabrutinib	1575596-29-0	99.76%
PRN1008 is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK)(IC50 of 1.3 nM).
T5138	BMS-986142	1643368-58-4	99.76%
BMS-986142 is a potent and highly selective reversible BTK inhibitor (IC50: 0.5 nM).
T4337	PCI 29732	330786-25-9	99.79%
PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.
T1835	Ibrutinib	936563-96-1	99.79%
Ibrutinib is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation.
T8636	Ibrutinib deacryloylpiperidine	330786-24-8	99.8%
Ibrutinib deacryloylpiperidine is a highly selective Bruton’s tyrosine kinase (BTK) irreversible inhibitor with an IC50 of 0.5 nM.
T3024	Avitinib	1557267-42-1	99.87%
Avitinib, also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor, with potent...
T10625	IBT6A	1022150-12-4	99.88%
IBT6A is an impurity of Ibrutinib. Ibrutinib is a Btk inhibitor (IC50: 0.5 nM). IBT6A can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct.
T14681	BMS-935177	1231889-53-4	99.89%
BMS-935177 is a reversible BTK inhibitor with IC50 value of 3 nM.
T36287	Pirtobrutinib	2101700-15-4	99.89%
Pirtobrutinib (LOXO-305), a highly selective and non-covalent next generation BTK inhibitor. Pirtobrutinib inhibits diverse BTK C481 substitution mutations. Pirt...
T6217	LFM-A13	244240-24-2	99.9%
LFM-A13（IC50=2.5 μM）, a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and...
T12311	Tirabrutinib hydrochloride	1439901-97-9
Tirabrutinib hydrochloride is a selective and novelBTK with IC50 2.2 nm inhibitor.
T9408	N-piperidine Ibrutinib	330785-90-5
N-piperidine Ibrutinib is a potent BTK inhibitor with IC50s of 51.0 for WT BTK and 30.7 nM for C481S BTK respectively[1]. N-piperidine Ibrutinib can be used as a...
T16157	MT-802	2231744-29-7	95.93%
MT-802 is an effective BTK degrader based on PROTAC technology (DC50: 1 nM). MT-802 has the potential to treat C481S mutant chronic lymphocytic leukemia (CLL).

Cat. No.

Product name

CAS No.

Purity

Chemical Structure

T9706

BTK inhibitor 17

1858206-76-4

99.57%

BTK inhibitor 17 is a potent irreversible BTK inhibitor (IC50 = 2.1 nM). BTK inhibitor 17 can be used in rheumatoid arthritis studies.

T14323

ARQ 531

2095393-15-8

99.59%

ARQ-531 is a potent and orally active BTK inhibitor with potential antineoplastic activity, with IC50s of 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectiv...

T4391

Syk Inhibitor II (hydrochloride)

227449-73-2

99.59%

Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chain...

T6078

Saracatinib

379231-04-6

99.63%

Saracatinib (AZD0530) is an effective Src inhibitor (IC50: 2.7 nM), and effective to Lck, Fyn, Lyn, Blk, Fgr and c-Yes.

T17098

Tilfrinib

1600515-49-8

99.73%

Tilfrinib is an effective and selective inhibitor of breast tumor kinase(Brk, IC50 = 3.15 nM) which displays anti-proliferative and anti-tumor activities.

T7584

Zanubrutinib

1691249-45-2

99.74%

Zanubrutinib is an inhibitor of Bruton tyrosine kinase (BTK).

T12542

Rilzabrutinib

1575596-29-0

99.76%

PRN1008 is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK)(IC50 of 1.3 nM).

T5138

BMS-986142

1643368-58-4

99.76%

BMS-986142 is a potent and highly selective reversible BTK inhibitor (IC50: 0.5 nM).

T4337

PCI 29732

330786-25-9

99.79%

PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.

T1835

Ibrutinib

936563-96-1

99.79%

Ibrutinib is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation.

T8636

Ibrutinib deacryloylpiperidine

330786-24-8

99.8%

Ibrutinib deacryloylpiperidine is a highly selective Bruton’s tyrosine kinase (BTK) irreversible inhibitor with an IC50 of 0.5 nM.

T3024

Avitinib

1557267-42-1

99.87%

Avitinib, also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor, with potent...

T10625

IBT6A

1022150-12-4

99.88%

IBT6A is an impurity of Ibrutinib. Ibrutinib is a Btk inhibitor (IC50: 0.5 nM). IBT6A can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct.

T14681

BMS-935177

1231889-53-4

99.89%

BMS-935177 is a reversible BTK inhibitor with IC50 value of 3 nM.

T36287

Pirtobrutinib

2101700-15-4

99.89%

Pirtobrutinib (LOXO-305), a highly selective and non-covalent next generation BTK inhibitor. Pirtobrutinib inhibits diverse BTK C481 substitution mutations. Pirt...

T6217

LFM-A13

244240-24-2

99.9%

LFM-A13（IC50=2.5 μM）, a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and...

T12311

Tirabrutinib hydrochloride

1439901-97-9

Tirabrutinib hydrochloride is a selective and novelBTK with IC50 2.2 nm inhibitor.

T9408

N-piperidine Ibrutinib

330785-90-5

N-piperidine Ibrutinib is a potent BTK inhibitor with IC50s of 51.0 for WT BTK and 30.7 nM for C481S BTK respectively[1]. N-piperidine Ibrutinib can be used as a...

T16157

MT-802

2231744-29-7

95.93%

MT-802 is an effective BTK degrader based on PROTAC technology (DC50: 1 nM). MT-802 has the potential to treat C481S mutant chronic lymphocytic leukemia (CLL).