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AChE

Acetylcholinesterase, also known as AChE, AChase or acetylhydrolase, is the primary cholinesterase in the body. It is an enzyme that catalyzes the breakdown of acetylcholine and some other choline esters that function as neurotransmitters. AChE is found at mainly neuromuscular junctions and in chemical synapses of the cholinergic type, where its activity serves to terminate synaptic transmission. It belongs to the carboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T60739L Y13g dihydrochloride T60739L 97.81%
Y13g dihydrochloride
Y13g dihydrochloride is a potent inhibitor of interleukin 6 (IL-6) and acetylcholinesterase (AChE) (both targets of Alzheimer's disease (AD) progression are rela...
T6S0653 Linarin 480-36-4 97.81%
Linarin
1. Linarin (Acacetin-7-O-rutinoside) (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviate...
T13301 Violanthin 40581-17-7 97.81%
Violanthin
Violanthin is a natural product isolated from the aerial parts of Piper bavinum and inhibits acetylcholinesterase (AChE) (IC50: 79.80 μM). It has potent antioxid...
TN6919 Methyl tridecanoate 1731-88-0 97.63%
Methyl tridecanoate
Methyl tridecanoate is a natural product.
T5S1025 Picfeltarraenin IA 97230-47-2 97.51%
Picfeltarraenin IA
1. Picfeltarraenin IA (Picfeltarraenin A), IB, IV, X, XI are stronger AChE inhibitions than the known AChE inhibitor Tacrine.
TN1899 Lycoramine 21133-52-8 96.19%
Lycoramine
Lycoramine is a natural product isolated from Lycoris radiate. Lycoramine is a potent acetylcholinesterase (AChE) inhibitor
T50066 1-[10-(pyridin-1-ium-1-yl)decyl]pyridin-1-ium dibromide 6266-40-6 95.00%
1-[10-(pyridin-1-ium-1-yl)decyl]pyridin-1-ium dibromide
1-[10-(pyridin-1-ium-1-yl)decyl]pyridin-1-ium dibromide is the inhibitor of human erythrocyte AChE.
T20539 Pirimiphos-methyl 29232-93-7 95%
Pirimiphos-methyl
Pirimiphos-methyl (AI3-27699) is a rapid-acting organophosphorus insecticide and acaricide, causing inhibition of AChE in target organisms. Pirimiphos-methyl is ...
T5S2343 Acetylshikonin 24502-78-1 92.45%
Acetylshikonin
1. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC5 of over 2 microM, exhibits the antiangiogenic and a...
T1635 Fenchlorphos 299-84-3 100%
Fenchlorphos
Fenchlorphos (Dermafos) is a cholinesterase inhibitor, used as an insecticide.
T2759 Loganin 18524-94-2 100%
Loganin
Loganin (Loganoside), an iridoid glucoside, has been reported to be an inhibitor of Cox-1 and also noted to suppress TNF-α formation. This compound also has disp...
TN1528 Cotoin 479-21-0 100%
Cotoin
Cotoin is a natural product isolated from the stem bark of Garcinia virgate.Cotoin has antispasmodic activity and reduces the tone and contraction of isolated ra...
T19084 1-Naphthyl acetate 830-81-9
1-Naphthyl acetate
1-Naphthyl acetate is usually used in a rapid staining method for identification of macrophages. 1-Naphthyl acetate is a potent chromogenic substrate for the det...
T77758 AChE/BuChE-IN-4 1997158-25-4 98%
AChE/BuChE-IN-4
AChE/BuChE-IN-4 is a multi-target AChE/BuChE inhibitor with oral activity and blood-brain barrier permeability, with IC50 values of 2.08 and 7.41 μM for AChE and...
T83616 SEW06622 261349-28-4 98%
SEW06622
SEW06622 is a potent inhibitor of acetylcholinesterase (AChE) and beta-secretase-1 (BACE-1) and is a potential candidate for the treatment of Alzheimer's disease...
T4466 Pitofenone hydrochloride 1248-42-6 98%
Pitofenone hydrochloride
Pitofenone hydrochloride (Pitophenone hydrochloride), a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from...
T0338 Minaprine 25905-77-5 98%
Minaprine
Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states.
T3S1612 Kuwanon G 75629-19-5 98%
kuwanon G
1. Kuwanon G (Moracenin B) as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective ...
TN1403 Arjunolic acid 465-00-9 98%
Arjunolic acid
Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the devel...
T3769 Tenuifolin 20183-47-5 98%
Tenuifolin
Tenuifolin has no inherent toxicity to either the transfected or wild type cells at the effective concentrations, it inhibits amyloid-β secretion in vitro.
Y13g dihydrochloride
T60739L
Y13g dihydrochloride is a potent inhibitor of interleukin 6 (IL-6) and acetylcholinesterase (AChE) (both targets of Alzheimer's disease (AD) progression are rela...
Linarin
T6S0653
1. Linarin (Acacetin-7-O-rutinoside) (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviate...
Violanthin
T13301
Violanthin is a natural product isolated from the aerial parts of Piper bavinum and inhibits acetylcholinesterase (AChE) (IC50: 79.80 μM). It has potent antioxid...
Methyl tridecanoate
TN6919
Methyl tridecanoate is a natural product.
Picfeltarraenin IA
T5S1025
1. Picfeltarraenin IA (Picfeltarraenin A), IB, IV, X, XI are stronger AChE inhibitions than the known AChE inhibitor Tacrine.
Lycoramine
TN1899
Lycoramine is a natural product isolated from Lycoris radiate. Lycoramine is a potent acetylcholinesterase (AChE) inhibitor
1-[10-(pyridin-1-ium-1-yl)decyl]pyridin-1-ium dibromide
T50066
1-[10-(pyridin-1-ium-1-yl)decyl]pyridin-1-ium dibromide is the inhibitor of human erythrocyte AChE.
Pirimiphos-methyl
T20539
Pirimiphos-methyl (AI3-27699) is a rapid-acting organophosphorus insecticide and acaricide, causing inhibition of AChE in target organisms. Pirimiphos-methyl is ...
Acetylshikonin
T5S2343
1. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC5 of over 2 microM, exhibits the antiangiogenic and a...
Fenchlorphos
T1635
Fenchlorphos (Dermafos) is a cholinesterase inhibitor, used as an insecticide.
Loganin
T2759
Loganin (Loganoside), an iridoid glucoside, has been reported to be an inhibitor of Cox-1 and also noted to suppress TNF-α formation. This compound also has disp...
Cotoin
TN1528
Cotoin is a natural product isolated from the stem bark of Garcinia virgate.Cotoin has antispasmodic activity and reduces the tone and contraction of isolated ra...
1-Naphthyl acetate
T19084
1-Naphthyl acetate is usually used in a rapid staining method for identification of macrophages. 1-Naphthyl acetate is a potent chromogenic substrate for the det...
AChE/BuChE-IN-4
T77758
AChE/BuChE-IN-4 is a multi-target AChE/BuChE inhibitor with oral activity and blood-brain barrier permeability, with IC50 values of 2.08 and 7.41 μM for AChE and...
SEW06622
T83616
SEW06622 is a potent inhibitor of acetylcholinesterase (AChE) and beta-secretase-1 (BACE-1) and is a potential candidate for the treatment of Alzheimer's disease...
Pitofenone hydrochloride
T4466
Pitofenone hydrochloride (Pitophenone hydrochloride), a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from...
Minaprine
T0338
Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states.
kuwanon G
T3S1612
1. Kuwanon G (Moracenin B) as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective ...
Arjunolic acid
TN1403
Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the devel...
Tenuifolin
T3769
Tenuifolin has no inherent toxicity to either the transfected or wild type cells at the effective concentrations, it inhibits amyloid-β secretion in vitro.
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TargetMol