udp-glucuronic acid

UDP-glucuronic acid trisodium (UDP-glucuronic acid trisodium) is an indispensable precursor for vital glycoconjugates in various biological domains. These glycoconjugates encompass mammalian glycosaminoglycans, plant cell wall polysaccharides, and bacterial capsule glycoglycerolipids.

UDP-Glucuronic acid is a nucleoside diphosphate sugar that is a source of glucuronic acid for polysaccharide biosynthesis. This compound can be used for the formation of many glucuronides with various aglycones.1 1.Green, M.D., and Tephly, T.R.Glucuronidation of amine substrates by purified and expressed UDP-glucuronosyltransferase proteinsDrug Metab. Dispos.26(9)860-867(1998)

UX4O is an allosteric inhibitor of UDP-glucose dehydrogenase (UGDH). The human UGDH (hUGDH) is a hexamer that catalyzes the oxidation of UDP-glucose to UDP-glucuronic acid. It exists in an active (E) state and an inactive (EΩ) state, which requires binding with the allosteric inhibitor UDP-xylose (UDP-Xyl) to stabilize the inactive form. UX4O may also serve as a physiologically relevant inhibitor of bacterial allosteric UGDH that does not produce UDP-Xyl.

Imidafenacin metabolite M4 is a metabolite of the muscarinic acetylcholine receptor antagonist imidafenacin.1It is formed from imidafenacin by the cytochrome P450 (CYP) isoform CYP3A4. 1.Kanayama, N., Kanari, C., Masuda, Y., et al.Drug-drug interactions in the metabolism of imidafenacin: Role of the human cytochrome P450 enzymes and UDP-glucuronic acid transferases, and potential of imidafenacin to inhibit human cytochrome P450 enzymesXenobiotica37(2)139-154(2007)

Uridine-5'-diphosphoglucuronic acid is a nucleoside diphosphate sugar that is a source of glucuronic acid for polysaccharide biosynthesis. This compound can be used for the formation of many glucuronides with various aglycones.1 1.Green, M.D., and Tephly, T.R.Glucuronidation of amine substrates by purified and expressed UDP-glucuronosyltransferase proteinsDrug Metab. Dispos.26(9)860-867(1998)

Uridine diphosphate glucuronic acid ammonium (UDP-α-D-glucuronic acid ammonium) is a precursor of many plant cell wall polysaccharides and is required for the production of seed mucilage.Uridine diphosphate glucuronic acid ammonium is a precursor of pathogenic fungi. ammonium is a key metabolite for pod polysaccharide synthesis in the pathogenic fungus Cryptococcus neoformans.

Uridine diphosphate glucuronic acid (UDP-GlcA) trisodium is a cofactor formed by the catalytic activity of UDP-glucose dehydrogenase. It contains an Azide group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules that have Alkyne groups. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition reactions (SPAAC) with molecules containing DBCO or BCN groups.