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Results for "
tsr 011 isomer
" in TargetMol Product Catalog.- Inhibitors & Agonists2
TSR-011-isomer
TSR-011 isomer, TSR011 isomer, Belizatinib isomer
T290201388225-79-3
TSR011-isomer, a TrKA/ALK inhibitor, is used potentially for the treatment of solid tumours and lymphoma.
- $1,970
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(E)-Belizatinib
(E)-TSR-011
T2145021388225-72-6
(E)-Belizatinib ((E)-TSR-011) (compound 36) is the (E)-isomer of Belizatinib, and serves as a potent, highly selective, and orally active inhibitor of anaplastic lymphoma kinase (ALK), with an enzymatic IC50 of 0.005 μM and a cellular IC50 of 0.048 μM. The compound exhibits over 61-fold selectivity against JAK2, SRC, and IGF1R, and demonstrates excellent efficacy and pharmacokinetic properties in rats and dogs. (E)-Belizatinib is applicable for research in ALK-driven cancers.
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