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By Target- Apoptosis
- IκB/IKK(1)
- STAT(1)
- Others(1)
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Results for "
tpca-1
" in TargetMol Product Catalog- Inhibitors & Agonists2
TPCA-1
GW683965, IKK2 Inhibitor IV, TPCA1
T3049507475-17-4
TPCA-1 (TPCA1) is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM); shows >22-fold selectivity over IKK-1 and >550-fold selectivity over others kinases and enzymes.
- Inquiry Price
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StA-IFN-1
T38158300839-31-0
StA-IFN-1 is an inhibitor of the interferon (IFN) induction pathway with an IC50 value of 4.1 μM in a GFP reporter assay for IFN induction similar to TPCA-1 , which specifically inhibits the IKKβ component of the IFN induction pathway. It does not show inhibitory activity in a GFP reporter assay for IFN signaling in which ruxolitinib , which is specific for the IFN signaling component JAK1, is active. StA-IFN-1 reduces the levels of IFN-β, but not ISG MxA, mRNA, suggesting that it is selective for the IFN induction pathway and not the IFN signaling pathway.
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