thalidomide piperazine boc

Thalidomide-piperazine-Boc, an intermediate used in the synthesis of BCL6 PROTAC, targets the B-cell lymphoma 6 protein.

Thalidomide-piperidine-C2-piperazine-Boc is an E3 Ligase Ligand-linker conjugate comprising a cereblon ligand based on Thalidomide and a linker. This compound is utilized in the synthesis of PROTAC.

PROTAC ER Degrader-14 (compound 86) is a PROTAC-type estrogen receptor ERR degrader. It comprises an E3 ubiquitin ligase ligand (blue part) (S)-Deoxy-thalidomide, a PROTAC linker (black part) N-Boc-piperazine, and a target protein ligand (red part) ER ligand-6. The combination of the E3 ligase and linker forms tert-Butyl (S)-4-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)piperazine-1-carboxylate.