tco-peg4-acid

TCO-PEG4-acid is a PEG-based linker for PROTACs, facilitating the connection of two essential ligands crucial for forming PROTAC molecules, thereby enabling selective protein degradation through the ubiquitin-proteasome system within cells.

(S)-TCO-PEG4-acid is a PEG-based linker for PROTACs, joining two essential ligands critical for PROTAC molecule formation, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent featuring a tetrazine group, capable of undergoing inverse electron demand Diels-Alder (iEDDA) reactions with molecules containing TCO groups. This PEGylated derivative possesses a methyltetrazine moiety and two acidic groups. It forms stable covalent bonds with TCO-bearing compounds through a rapid and selective Diels-Alder cycloaddition, without the need for Cu catalysis or high temperatures. Additionally, its terminal carboxylic acids can react with primary amines in the presence of activators (such as EDC or HATU) to form stable amide bonds. The PEG linkage enhances the compounds water solubility. This reagent is for research use only.

TCO-PEG4-TFP ester is an amine-reactive labeling reagent used for the modification of proteins, antibodies, and other amine-containing biopolymers. TFP is a reactive ester that demonstrates superior stability during hydrolysis in aqueous media, enhancing the efficiency and reproducibility of biopolymer labeling. The TFP ester of carboxylic acid reacts with primary amines at a rate equivalent to NHS esters, forming a covalent amide bond identical to that produced by the reaction of primary amines with NHS or sulfo-NHS esters.