tau peptide

Tau Peptide (275-305), also known as the R2 domain fragment, represents the second repeat unit of the microtubule-binding domain of the Alzheimer's tau peptide. Tau Peptide (275-305) is considered crucial in determining the biochemical characteristics of the complete tau protein.

Acetyl-Tau Peptide (273-284) amide, an acetylated fragment of the Tau peptide, inhibits the significant aggregation of Ac-Aβ(25–35)-NH2 and serves as a model for studying the cross-interaction between Aβ and Tau [1] [2].

CHIPOpt is a peptide and an orthosteric inhibitor of the CHIP TPR domain, with a dissociation constant (Kd) of approximately 16 nM. It exhibits anti-aggregation properties and reduces p.tau ubiquitination, while having minimal impact on unmodified tau protein. CHIPOpt is applicable in Alzheimer's disease research.

Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is predominantly active in neuronal tissues. With p25 or p35, Cdk5 phosphorylates a range of proteins, including histone H1 and tau. Cdk5 substrate is a synthetic peptide (PKTPKKAKKL) corresponding to a sequence of histone H1. It is phosphorylated by Cdk5 with a Km value of 5 μM.

Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is predominantly active in neuronal tissues. With p25 or p35, Cdk5 phosphorylates a range of proteins, including histone H1 and tau. Cdk5 Substrate acetate is a synthetic peptide (PKTPKKAKKL) corresponding to a sequence of histone H1. It is phosphorylated by Cdk5 with a Km value of 5 µM.

Acetyl-PHF5 amide is a tau peptide with amyloidogenic properties. It can undergo polymerization to form filamentous structures [1].

hAChE-IN-5 (compound 49) is a dual inhibitor of human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBuChE), showing IC50 values of 0.17 μM for both enzymes. It also potently inhibits glycogen synthase kinase 3 beta (GSK3β) with an IC50 of 0.21 μM. Furthermore, it effectively inhibits tau protein and Aβ1-42 peptide self-aggregation, and can bind the peripheral anionic site (PAS) to prevent amyloid-beta (Aβ)-induced neurotoxicity. hAChE-IN-5's ability to cross the blood-brain barrier (BBB) supports its potential in developing multitargeted anti-Alzheimer's agents [1].

AADvac1 is a biologically active peptide functioning as an Alzheimer's Disease Peptide Vaccine, composed of Tau(294–305) conjugated to Keyhole Limpet Hemocyanin (KLH).

Microtubule-associated protein tau (26-44) is a synthetic peptide with an amino group conjugated to glutamine and a carboxyl group conjugated to lysine.

Tau protein (592-597), Human (TFA) is a peptide fragment of human Tau protein.

Tau conotoxin CnVA, a small peptide found in the venom of Conus consors (cone snail), is a member of the T1 cone snail peptide superfamily. It demonstrates high selectivity for the somatostatin sst3 receptor with a Ki value of 1.5 µM. Tau conotoxin CnVA is unique as the only known toxin interacting with this subfamily of G protein-coupled receptors (GPCR). This compound is useful for research related to diseases associated with the sst3 receptor, such as pancreatic cancer or pituitary adenomas.

RI-AG03 is an orally active peptide inhibitor capable of crossing the blood-brain barrier, targeting Tau aggregation. It effectively inhibits Tau aggregation in both in vivo and in vitro models, improving associated neurodegenerative and behavioral phenotypes. RI-AG03 is applicable in research on Tauopathies such as Alzheimer's disease.

AADvac 1 TFA is an active tau peptide vaccine utilized in Alzheimer's disease research. It is formed by conjugating the regulatory peptide 294KDNIKHVPGGGS305, which drives tau oligomerization, with keyhole limpet hemocyanin (KLH), and is formulated with aluminum hydroxide.

RI-AG03 acetate is the acetate form of RI-AG03. RI-AG03 is an orally active peptide inhibitor that can cross the blood-brain barrier to inhibit Tau aggregation. It effectively prevents Tau aggregation in both in vivo and in vitro models and improves associated neurodegenerative and behavioral phenotypes. RI-AG03 is useful for researching tauopathies such as Alzheimer's disease.