sec61 in 2

Sec61-IN-2 (A347) is a protein secretion inhibitor. This compound effectively interferes with the Sec61-mediated translocation mechanism, thereby inhibiting the movement of proteins across the endoplasmic reticulum membrane, which disrupts cellular functioning.

Sec61-IN-2 (A3) is a protein secretion inhibitor.

Cotransin, a Sec61 translocation inhibitor, selectively prevents the stable insertion of certain nascent chains into the Sec61 translocation channel, exhibiting signal-sequence discrimination. This compound also inhibits the expression of VCAM-1 and p-selectin proteins by blocking their co-translational translocation across endoplasmic reticulum (ER) membranes (IC 50 =0.5-5 µM). Cotransin's role extends to potential applications in inflammation and immunity research [1] [2].