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(2)
By Target- ROCK
- Wnt/beta-catenin(1)
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By Target By ResearchField- Cardiovascular System(1)
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Results for "
sb-772077b
" in TargetMol Product Catalog.- Inhibitors & Agonists2
SB-772077B dihydrochloride
T16855607373-46-6
SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor with IC50 values of 5.6 nM for ROCK1 and 6 nM for ROCK2.
- $95
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SB772077B
T213810785774-34-7
SB772077B is a ROCK inhibitor with anti-inflammatory properties. It boosts aqueous humor outflow (OF) by inhibiting the RhoA/ROCK signaling pathway. This compound significantly reduces mRNA levels of β-catenin and protein levels of fibrosis markers such as vinculin, fibronectin, collagen1 A, and vimentin. Additionally, SB772077B exhibits vasodilatory effects, lowering both pulmonary arterial and systemic blood pressure. It is useful for research on glaucoma and pulmonary arterial hypertension.
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