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By Target- ALK
- TGF-beta/Smad(1)
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Results for "
sb 505124
" in TargetMol Product Catalog- Inhibitors & Agonists2
SB-505124 hydrochloride
SB505124 hydrochloride, SB 505124 hydrochloride
T21637356559-13-2
SB-505124 hydrochloride (SB505124 hydrochloride) is an orally available, selective and potent inhibitor of TGF-β type I receptors (ALK4, ALK5, ALK7) with IC50 values of 129 nM and 47 nM for ALK4 and ALK5, respectively. SB-505124 hydrochloride inhibits IL-6 production by synovial explants and reduces Th17 differentiation in mice by decreasing Il17a and Rorc gene expression and IL-17 protein production.SB-505124 hydrochloride is used in the study of colorectal cancer.
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