rbin 1

Rbin-1 (Ribozinoindole-1) is a potent,specific inhibitor of eukaryotic ribosome biogenesis.

Autophagy/REV-ERB-IN-1 is a dual inhibitor of autophagy and REV-ERB. It exhibits antitumor activity, with a CC50 value of 2.3 μM in BTB-474 cells.

Autophagy/REV-ERB-IN-1 hydrochloride (Compound 24) is a dual inhibitor of autophagy and REV-ERB with anticancer properties. It enhances the efficacy of autophagy blockade and increases cytotoxicity against cancer cells. Autophagy/REV-ERB-IN-1 (hydrochloride) is applicable in melanoma research.

Factor B-IN-1 is a Factor B inhibitor (IC50 = 43 nM) and is an analog of compound 13. It is used to inhibit complement pathway factor B and has improved pharmacokinetic properties (oral availability in rats and dogs).

MurB-IN-1 (compound 44) is a potent inhibitor of MurB, an essential enzyme involved in the synthesis of the bacterial cell wall. With a binding affinity of Kd 3.57 μM, MurB-IN-1 effectively hinders MurB activity, presenting a promising therapeutic option against P. aeruginosa, a highly virulent and opportunistic pathogen associated with severe infections and mortality [1].

AcrB-IN-1 (Compound H6) is a potent inhibitor of AcrB, used to reverse bacterial multidrug resistance [1].