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Results for "
ractrans4hydroxy glyburide
" in TargetMol Product Catalog- Inhibitors & Agonists1
rac-trans-4-hydroxy Glyburide
T3563523155-00-2
rac-trans-4-hydroxy Glyburide, an active metabolite of the SUR1 Kir6.2 sulfonylurea inhibitor glyburide, is formed by the cytochrome P450 (CYP) isoforms CYP2C8 and CYP2C9. It inhibits glyburide binding to rat brain synaptosomes at high and low affinity sites of SUR1 Kir6.2 with IC50 values of 0.95 and 100 nM, respectively.
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