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ps423

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  • Inhibitors & Agonists
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    TargetMol | Inhibitors_Agonists
PS423
PS210AM, PS 423, PS-423, PS210-AM, PS 210 AM
T246761221964-37-9In house
PS423 (PS210AM) is a substrate-selective inhibitor of PDK1 and a selective PDK1 activator that inhibits the phosphorylation and activation of S6K, and is used in the study of endocrine and metabolic disorders.
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6-8 weeks
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PS210
T166701221962-86-2
PS210 is a potent and selective activator of PDK1 (Kd: 3 μM), specifically targeting the PIF-binding pocket of PDK1 without affecting other protein kinases such as S6K, PKB Akt, or GSK3. Its prodrug, PS423, serves as a substrate-selective inhibitor of PDK1 in cells, inhibiting the phosphorylation and activation of S6K.
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