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(2)
By Target- Syk
- Apoptosis(1)
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By Target By ResearchField- Cancer(1)
- Inflammation(1)
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Results for "
prt 060318
" in TargetMol Product Catalog.- Inhibitors & Agonists2
PRT-060318
PRT318, P142-76
T69571194961-19-7
PRT-060318 (P142-76) is a novel selective inhibitor of the Syk tyrosine kinase, as an approach to HIT treatment.
- $35
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PRT-060318 dihydrochloride
PRT318 dihydrochloride
T2138883032567-93-1
PRT-060318 (PRT318) dihydrochloride is a potent, highly selective tyrosine kinase Syk inhibitor with an IC50 of 3 nM, and is orally bioavailable. It inhibits the activation and migration of B cells in chronic lymphocytic leukemia (CLL) and induces apoptosis. Additionally, PRT-060318 dihydrochloride offers potential therapeutic applications by preventing heparin-induced thrombocytopenia and thrombosis in transgenic mouse models, making it useful in studies of chronic lymphocytic leukemia and thrombosis.
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