prostatic vegf

AhR modulator-1 is a selective and orally active aryl hydrocarbon receptor (AhR) modulator. It inhibits metastasis, in part, by inhibiting prostatic VEGF production prior to tumor formation. It also possesses anti-estrogenic properties in rat uterus.

6'-Sialyllactose (6'-SL) is one of the most predominant human milk oligosaccharides (HMOs) with significant prebiotic activity, promoting the growth of beneficial bacteria (e.g., Bifidobacterium and Lactobacillus) while inhibiting harmful pathogens. 6'-SL exhibits pleiotropic biological activities: it diminishes stress-induced anxiety via the gut-brain axis, ameliorates benign prostatic hyperplasia by suppressing VEGF-mediated angiogenesis (via Akt-ERK inhibition), and enhances exercise performance by increasing muscle mass and strength. It also reduces the internalization of Pseudomonas aeruginosa in human pneumocytes.